Imidazolium-based titanium substrates against bacterial colonization.

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Imidazolium-based titanium substrates against bacterial colonization.

Biomater Sci. 2017 Feb 28;5(3):561-569

Authors: Cavoue T, Bounou Abassi H, Vayssade M, Nguyen Van Nhien A, Kang IK, Kwon GW, Pourceau G, Dubot P, Abbad Andaloussi S, Versace DL

Abstract
Nosocomial infections are often induced by the presence of pathogenic organisms on the surface of medical devices or hospital equipment. Chemical modifications of the surface are recognized as efficient strategies to prevent bacterial adhesion but they may have a negative impact on the material's interaction with living tissues. Here we have developed a photoactivated method for the modification of titanium substrates. A photoinduced technique employing a grafting-onto process has been successfully performed to covalently anchor an imidazolium-derivative siloxane onto titanium surfaces. Imidazolium surfaces showed higher bacteria-repellency performances than native titanium substrates, achieving more than 98% anti-adhesion efficiency against Escherichia coli after 24 h of incubation. In addition, these surfaces allowed for the adhesion and viability of osteoblasts cells without evidence of cytotoxicity.

PMID: 28138661 [PubMed - indexed for MEDLINE]

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