Screening of ligands for redox-active europium using magnetic resonance imaging

Publication date: Available online 4 April 2018
Source:Bioorganic & Medicinal Chemistry
Author(s): Brooke A. Corbin, Lina A. Basal, Susan A. White, Yimin Shen, E. Mark Haacke, Kenneth W. Fishbein, Matthew J. Allen
We report a screening procedure to predict ligand coordination to Eu^II and Eu^III using magnetic resonance imaging in which bright images indicate complexation and dark images indicate no complexation. Here, paramagnetic Gd^III is used as a surrogate for Eu^III in the screening procedure to enable detection with magnetic resonance imaging. The screening procedure was tested using a set of eight ligands with known coordination to Eu^II and Eu^III, and results were found to be consistent with expected binding. Validation of the screening procedure with known coordination chemistry enables use with new ligands in the future.

Graphical abstract

https://ift.tt/2uN9kjr