Tumor-derived extracellular vesicles in angiogenesis

Publication date: June 2018
Source:Biomedicine & Pharmacotherapy, Volume 102
Author(s): Wei Song, Dong Yan, Tianshu Wei, Qiang Liu, Xia Zhou, Ju Liu
Angiogenesis is crucial for tumor growth and metastasis. Recent studies revealed that tumor cells promote angiogenesis by secreting extracellular vesicles, which can be captured by endothelial cells. These tumor-derived extracellular vesicles carry microRNAs, long non-coding RNAs, and proteins, which activate pro-angiogenic signaling in endothelial cells. In this review, we will summarize the roles of tumor-derived extracellular vesicles in angiogenesis and the underlying molecular mechanisms.



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