Lipo-prostaglandin E1 improves renal hypoxia evaluated by BOLD-MRI in patients with diabetic kidney disease

Publication date: July–August 2018
Source:Clinical Imaging, Volume 50
Author(s): Zhi-Cheng Li, Yu-Zhe Cai, Zhi-Gang Tang, Pan-Li Zuo, Rong-Bo Liu, Fang Liu
ObjectiveTo evaluate the effect of lipo-PGE1 on renal hypoxia in patients with DKD by BOLD-MRI.Materials and methodsAll patients were divided into DKD group and CKD-without-diabetes group. All patients received intravenous 10 μg lipo-PGE1 once daily for 14 days. BOLD-MRI was performed before and after lipo-PGE1 administration to acquire renal CR2* and MR2* values.ResultsRenal MR2* value in DKD group after lipo-PGE1 treatment were significantly decreased compared with the baseline. However, no significant differences in MR2* values were found in the CKD-without-diabetes group.ConclusionsLipo-PGE1 was shown to improve kidney medullary oxygenation in patients with DKD.



https://ift.tt/2IdsWCL