Paget’s Disease of Bone

Publication date: Available online 26 May 2018
Source:Best Practice & Research Clinical Endocrinology & Metabolism
Author(s): Natasha M. Appelman-Dijkstra, Socrates E. Papapoulos
Paget's disease of bone is a focal disorder of bone remodelling that progresses slowly and leads to changes in the shape and size of affected bones and to skeletal, articular and vascular complications. In some parts of the world it is the second most common bone disorder after osteoporosis though in recent years its prevalence and severity appear to decrease. The disease is easily diagnosed and effectively treated but its pathogenesis remains incompletely understood.



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