Synaptotagmins Tweak Functional β Cell Maturation

Publication date: 7 May 2018
Source:Developmental Cell, Volume 45, Issue 3
Author(s): Jennifer M. Gilbert, Barak Blum
Immature β cells secrete insulin at a lower glucose threshold compared to mature β cells. In this issue of Developmental Cell, Huang et al. (2018) show that the increase in glucose threshold during β cell maturation is achieved through balance between the Ca²⁺-sensitive synaptotagmin 7 and the Ca²⁺-insensitive synaptotagmin 4.

Teaser

Immature β cells secrete insulin at a lower glucose threshold compared to mature β cells. In this issue of Developmental Cell, Huang et al. (2018) show that the increase in glucose threshold during β cell maturation is achieved through balance between the Ca²⁺-sensitive synaptotagmin 7 and the Ca²⁺-insensitive synaptotagmin 4.


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