The hippocampus in depth: a sublayer-specific perspective of entorhinal–hippocampal function

Publication date: October 2018
Source:Current Opinion in Neurobiology, Volume 52
Author(s): Manuel Valero, Liset Menendez de la Prida
Understanding how the brain represents events is a fundamental question in neuroscience. The entorhinal–hippocampal system is central to such representations, which are severely compromised in some neurological diseases. In spite of much progress, a comprehensive, integrated view of spatial, temporal and other aspects of episodic representation remains elusive. Here, we review recent data on the role of cell-type specific entorhinal inputs which excite deep and superficial CA1 pyramidal cells by direct and indirect pathways. We discuss how an entorhinal dialogue with deep-superficial CA1 cells can multiplex neuronal activity along theta phases and how their reactivation may be segregated during sharp-wave ripples. Thus, deep and superficial CA1 sublayers provide substrate for general hippocampal function.

Graphical abstract

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