A Clinical Study of HMME-PDT Therapy in Chinese Pediatric patients with Port-wine stain

Publication date: Available online 8 June 2018
Source:Photodiagnosis and Photodynamic Therapy
Author(s): Gan Li-qiang, Wang Hua, Ni Si-li, Tan Chun-hua
ObjectiveTo report our observations from a trial of the effectiveness and safety of hematoporphyrin monomethyl ether photodynamic therapy (HMME-PDT) in treating Chinese Pediatric patients port-wine stains (PWS).MethodFrom October 2017 to December 2017, the study recruited 82 patients of PWS with negative HMME skin test results. The patients received an intravenous injection of 5 mg/kg HMME and the affected areas were exposed to 532 nm LED green light, with the irradiation power density between 80–85 mW/cm². Each light spot was irradiated for 20–25 min. After two treatments, the clinical efficacy and posttreatment reactions at each treated area were observed.ResultThe patient age between 1 and 14 years old. 24 of the 82 cases were cured (29.27%) after two HMME-PDT treatment, 34 cases indicates a good efficacy (41.46%), 16 cases showed alleviation (19.51%), while 8 cases displayed no efficacy (9.76%). Pain was observed during treatment, and post-treatment edema was observed at the treated areas. No other obvious systematic adverse reaction were reported.ConclusionHMME-PDT is an effective and safe treatment for pediatric patients with PWS.



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