Source:Research in Developmental Disabilities
Author(s): Stephen R. Hooper, Deborah Hatton, John Sideris, Kelly Sullivan, Peter A. Ornstein, Donald B. Bailey
BackgroundExecutive functions (EF) have been identified as impaired in FXS, but few studies have examined their developmental trajectories.AimsThe primary aim of this longitudinal study was to examine the development of EF in young males with FXS compared to Mental Age (MA)-matched controls.Methods and ProceduresThe sample comprised 56 boys with FXS (ages 7–13 years), and 48 MA-matched typical boys (ages 4–8 years). EF tasks included measures of inhibitory control, working memory, cognitive flexibility/set-shifting, problem solving/planning, and processing speed. Tasks were administered at three time points over five-years.Outcomes and ResultsThe MA-Matched Typical boys significantly outperformed the FXS boys on all EF tasks, with the FXS Group showing a pattern of slow, but positive growth on most EF tasks. For working memory tasks, significant interactions were noted between MA and autism symptom severity, and MA and medication status. The probability of task completion increased with higher MA.Conclusions and ImplicationsThese findings contribute to our understanding of the development of EF in this population. They also lay the foundation for use of EF tasks in treatment efforts, particularly with respect to documenting improvements and practice effects, and in understanding associations with targeted developmental outcomes.
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