Unraveling Endocrine FGF Signaling Complex to Combat Metabolic Diseases

Publication date: Available online 9 June 2018
Source:Trends in Biochemical Sciences
Author(s): Yongde Luo, Weiqin Lu, Xiaokun Li
Metabolic homeostasis is critical to cellular and organismal health. The newly revealed crystal structures of the endocrine factors FGF21 and FGF23, in association with the glycosidase coreceptor Klotho and transmembrane tyrosine kinase FGFR, set a platform for structure-based novel drug design against common metabolic disorders.



https://ift.tt/2JAmgwd