A Lack of consistent brain alterations in insomnia disorder: an activation likelihood estimation meta-analysis

Insomnia disorder is a prevalent sleep disorder, which affects about 10% of general population. However, its neural mechanisms are poorly understood. Recently, several structural and functional neuroimaging studies have been conducted in patients with insomnia disorder, but these studies have yielded diverse findings. Here, we aimed to identify consistent patterns of abnormal brain alterations in insomnia disorder by performing a quantitative coordinate-based meta-analysis. Following the preferred reporting for systematic reviews and meta-analyses statement, we searched PubMed database and used reference tracking and finally retrieved 19 eligible studies (6 task-based functional magnetic resonance imaging, 8 resting-state functional magnetic resonance imaging, 3 voxel-based morphometry, and 2 positron emission tomography).

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