“In Search of An Ideal Closure Method: A Randomized, Controlled Trial of Octyl-2-cyanoacrylate and Adhesive Mesh Versus Subcuticular Suture in Reduction Mammoplasty”

BACKGROUND: An ideal wound closure system is one that is effective, consistent, and efficient. Recent studies have demonstrated the efficacy of octyl-2-cyanoacrylate and mesh (Dermabond® Prineo®, Ethicon, Inc.) in the closure of surgical wounds. This study compared the use of Prineo® to subcuticular suture closure in reduction mammoplasty. METHODS: A prospective, randomized, controlled, single-blind study of patients undergoing bilateral reduction mammoplasty was performed. Each breast per patient was randomized to layered closure with Prineo® or subcuticular sutures. Incisions were assessed at 2 weeks, 6 weeks, 6 months, and 1 year. Subjects completed the Patient Observer Scar Assessment Scale (POSAS) for each breast and two blinded plastic surgeons evaluated scar quality using the Vancouver Scar Scale (VSS) at each time point. RESULTS: Twenty-one patients participated in the study. On average, Prineo® closure took 58.38 seconds (2.50 s/cm) while subcuticular closure took 444.76 seconds (18.94 s/cm). Prineo® closure was approximately 6.8 times faster (p

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