Successful Treatment of Acromegaly and Associated Hypogonadism with First-Line Clomiphene Therapy.

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Successful Treatment of Acromegaly and Associated Hypogonadism with First-Line Clomiphene Therapy.

Case Rep Endocrinol. 2018;2018:7925019

Authors: Palacios JD, Komotar RJ, Kargi AY

Abstract
Clomiphene citrate (CC) has been reported as an effective add-on therapy to somatostatin analogs and dopamine agonists in patients with acromegaly accompanied by hypogonadism; its use as a single agent to treat acromegaly and associated hypogonadism following incomplete surgery has not been previously reported. We report the first case in which clomiphene was utilized as a single agent for the dual management of acromegaly and hypogonadism, not controlled by pituitary surgery alone. The treatment was well tolerated and proved to be effective after a process of treatment withdrawal and reintroduction. We propose that clomiphene may be considered as a cost-effective oral treatment option in select cases of hypogonadal acromegaly.

PMID: 30046497 [PubMed]

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