What Came First: The Microbiota or the Tr(egg) Cells?

Publication date: 19 June 2018

Source: Immunity, Volume 48, Issue 6

Author(s): Tal Gefen, Naama Geva-Zatorsky

Studies have shown that gut commensals facilitate the differentiation of peripheral regulatory T cells (pTregs) via their metabolic products. In this issue of Immunity, Campbell et al. (2018) demonstrate a reciprocal effect of pTregs on the metabolic functions of specific gut commensals that affects their overall energy harvest capacity.

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