Discovery of pre-therapy 2-deoxy-2- 18 F-fluoro-D-glucose positron emission tomography-based radiomics classifiers of survival outcome in non-small-cell lung cancer patients

Abstract

Purpose

The aim of this multi-center study was to discover and validate radiomics classifiers as image-derived biomarkers for risk stratification of non-small-cell lung cancer (NSCLC).

Patients and methods

Pre-therapy PET scans from a total of 358 Stage I–III NSCLC patients scheduled for radiotherapy/chemo-radiotherapy acquired between October 2008 and December 2013 were included in this seven-institution study. A semi-automatic threshold method was used to segment the primary tumors. Radiomics predictive classifiers were derived from a training set of 133 scans using TexLAB v2. Least absolute shrinkage and selection operator (LASSO) regression analysis was used for data dimension reduction and radiomics feature vector (FV) discovery. Multivariable analysis was performed to establish the relationship between FV, stage and overall survival (OS). Performance of the optimal FV was tested in an independent validation set of 204 patients, and a further independent set of 21 (TESTI) patients.

Results

Of 358 patients, 249 died within the follow-up period [median 22 (range 0–85) months]. From each primary tumor, 665 three-dimensional radiomics features from each of seven gray levels were extracted. The most predictive feature vector discovered (FVX) was independent of known prognostic factors, such as stage and tumor volume, and of interest to multi-center studies, invariant to the type of PET/CT manufacturer. Using the median cut-off, FVX predicted a 14-month survival difference in the validation cohort (N = 204, p = 0.00465; HR = 1.61, 95% CI 1.16–2.24). In the TESTI cohort, a smaller cohort that presented with unusually poor survival of stage I cancers, FVX correctly indicated a lack of survival difference (N = 21, p = 0.501). In contrast to the radiomics classifier, clinically routine PET variables including SUV_max, SUV_mean and SUV_peak lacked any prognostic information.

Conclusion

PET-based radiomics classifiers derived from routine pre-treatment imaging possess intrinsic prognostic information for risk stratification of NSCLC patients to radiotherapy/chemo-radiotherapy.

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Novel ethosomal gel of clove oil for the treatment of cutaneous candidiasis

Journal of Cosmetic Dermatology, EarlyView.


https://ift.tt/2NCUe56

Oral Ondansetron Offers Effective Antidiarrheal Activity for Carcinoid Syndrome Refractory to Somatostatin Analogs

AbstractObjectives.Somatostatin analogs (SSAs) are standard for symptomatic patients with neuroendocrine tumors (NETs). However, most patients experience tachyphylaxis, and limited options exist for this so‐called "refractory carcinoid syndrome." Recently, 5‐HT3 antagonist ondansetron has been associated with reduction of bowel movement in a small series. The aim of this analysis was to assess effectiveness of ondansetron for symptomatic treatment of carcinoid syndrome.Design and Patients.We have analyzed patients given ondansetron as bridging therapy for refractory carcinoid syndrome. The dose was 2 × 8 mg for 5 days, followed by reduction to 1 × 8 mg in case of benefit.Results.A total of 14 patients with small bowel NETs metastatic to the liver were identified. All patients had been treated with SSAs for a median time of 18 months before aggravation of diarrhea. One patient had to be excluded because of an underlying infectious cause of diarrhea. The median number of daily bowel movements was 7 (range, 5–13) before initiation of therapy. At this time, seven patients had stable disease, whereas six patients showed radiological progression with symptomatic breakthrough. All 13 patients were scheduled for salvage therapy. Remarkably, in 85% (11/13) ondansetron resulted in a clinically relevant decrease of bowel movements to a median of 3 (1–4). The median time of ondansetron intake was 29 days (7 days to 29 months). In four patients, diarrhea recurred after initial improvement at an interval of 22–43 days, whereas the remaining seven had an ongoing benefit, including two long‐term responders who refused further therapy because of pronounced decrease of symptoms (ondansetron for 14+ and 29+ months).Conclusion.Ondansetron offers symptomatic relief in the majority of patients. Although there was no influence on 5‐HIAA levels, evidence from two patients suggests prolonged benefit.Implications for Practice.Somatostatin analogs are standard treatment in patients with carcinoid syndrome and have an overall response rate of up to 50%. This symptomatic benefit, however, is lost in many patients because of the development of tachyphylaxis or tumor progression. Patients with this "refractory carcinoid syndrome" pose a therapeutic challenge and are sometimes faced with a detrimental effect on quality of life. In this article, the authors suggest the 5‐HT3 receptor antagonist ondansetron as potential symptomatic therapy for patients with refractory diarrhea due to carcinoid syndrome. Although the number of patients in this retrospective series is limited, treatment was easily applicable, feasible, and safe and resulted in an ongoing symptomatic benefit in 85% of patients, including two long‐term responders.

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Prognostic Value of the Progesterone Receptor by Subtype in Patients with Estrogen Receptor‐Positive, HER‐2 Negative Breast Cancer

AbstractBackground.In estrogen receptor‐positive (ER+), human epidermal growth factor receptor 2 (HER‐2) negative breast cancers, the progesterone receptor (PR) is an independent prognostic marker. Little is known about the prognostic value of PR by tumor grade. We assessed this in two independent datasets.Patients and Methods.Women with primary operable, invasive ER+ HER‐2 negative breast cancer diagnosed between 2000 and 2012, treated at University Hospitals Leuven, were included. We assessed the association of PR status and subtype (grade 1–2 vs. grade 3) with distant recurrence‐free interval (DRFI) and breast cancer‐specific survival. The interaction between PR status and subtype was investigated, and associations of PR status by subtype were calculated. The BIG 1‐98 data set was used for validation.Results.In total, 4,228 patients from Leuven and 5,419 from BIG 1‐98 were analyzed. In the Leuven cohort, the adjusted hazard ratio (HR) of PR‐positive versus PR‐negative tumors for DRFI was 0.66 (95% confidence interval [CI], 0.50–0.89). For the interaction with subtype (p = .34), the HR of PR status was 0.79 (95% CI, 0.61–1.01) in luminal A‐like and 0.59 (95% CI, 0.46–0.76) in luminal B‐like tumors. In luminal A‐like tumors, observed 5‐year cumulative incidences of distant recurrence were 4.1% for PR‐negative and 2.8% for PR‐positive tumors, and in luminal B‐like 18.7% and 9.2%, respectively. In the BIG 1‐98 cohort, similar results were observed; for the interaction with subtype (p = .12), the adjusted HR of PR status for DRFI was 0.88 (95% CI, 0.57–1.35) in luminal A‐like and 0.58 (95% CI, 0.43–0.77) in luminal B‐like tumors. Observed 5‐year cumulative incidences were similar.Conclusion.PR positivity may be more protective against metastatic relapse in luminal B‐like versus luminal A‐like breast cancer, but no strong conclusions can be made. In absolute risk, results suggest an absent PR is clinically more important in high compared with low proliferative ER+ HER‐2 negative tumors.Implications for Practice.An absent progesterone receptor (PR) predicts a worse outcome in women treated for an estrogen receptor‐positive, human epidermal growth factor receptor 2 negative breast cancer. As low proliferative tumors lacking PR are now also classified high risk, the prognostic value of PR across risk groups was studied. Despite a negative test for interaction of the prognostic value of PR by tumor grade, the magnitude of an absent PR on breast cancer relapse is much larger in high than in low proliferative breast cancers.

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The Role Of Primary Care Physicians in Childhood Cancer Survivorship Care: Multiperspective Interviews

AbstractBackground.Primary care physicians (PCPs) are well placed to provide holistic care to survivors of childhood cancer and may relieve growing pressures on specialist‐led follow‐up. We evaluated PCPs' role and confidence in providing follow‐up care to survivors of childhood cancer.Subjects, Materials, and Methods.In Stage 1, survivors and parents (of young survivors) from 11 Australian and New Zealand hospitals completed interviews about their PCPs' role in their follow‐up. Participants nominated their PCP for an interview for Stage 2. In Stage 2, PCPs completed interviews about their confidence and preparedness in delivering childhood cancer survivorship care.Results.Stage 1: One hundred twenty survivors (36% male, mean age: 25.6 years) and parents of young survivors (58% male survivors, survivors' mean age: 12.7 years) completed interviews. Few survivors (23%) and parents (10%) visited their PCP for cancer‐related care and reported similar reasons for not seeking PCP‐led follow‐up including low confidence in PCPs (48%), low perceived PCP cancer knowledge (38%), and difficulty finding good/regular PCPs (31%). Participants indicated feeling "disconnected" from their PCP during their cancer treatment phase. Stage 2: Fifty‐one PCPs (57% male, mean years practicing: 28.3) completed interviews. Fifty percent of PCPs reported feeling confident providing care to childhood cancer survivors. PCPs had high unmet information needs relating to survivors' late effects risks (94%) and preferred a highly prescriptive approach to improve their confidence delivering survivorship care.Conclusion.Improved communication and greater PCP involvement during treatment/early survivorship may help overcome survivors' and parents' low confidence in PCPs. PCPs are willing but require clear guidance from tertiary providers.Implications for Practice.Childhood cancer survivors and their parents have low confidence in primary care physicians' ability to manage their survivorship care. Encouraging engagement in primary care is important to promote holistic follow‐up care, continuity of care, and long‐term surveillance. Survivors'/parents' confidence in physicians may be improved by better involving primary care physicians throughout treatment and early survivorship, and by introducing the concept of eventual transition to adult and primary services. Although physicians are willing to deliver childhood cancer survivorship care, their confidence in doing so may be improved through better communication with tertiary services and more appropriate training.

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Cognitive behavioural therapy for eating disorders: how do clinician characteristics impact on treatment fidelity?

Abstract

Background

Clinicians routinely report not practising evidence-based treatments with eating disorders. There has been limited research investigating the impact of adaptable clinician characteristics such as self-efficacy and therapeutic optimism in this area. This study evaluated if there is a relationship between clinician therapeutic optimism, self-efficacy and the provision of evidence-based practice in the treatment of bulimia nervosa and binge eating disorder.

Method

A survey developed for this study was administered to 100 psychologists who were recruited online via a range of organisations affiliated with psychology and/or eating disorders. The survey measured demographic factors, eating disorder treatment knowledge, treatment fidelity, the use of individual treatment components and a range of clinician characteristics including self-efficacy and therapeutic optimism.

Results

Results demonstrated that clinician self-efficacy was positively associated with and predicted treatment fidelity. Therapeutic optimism had significant low correlations with treatment fidelity but did not predict treatment fidelity.

Conclusion

These findings would suggest that strengthening clinician self-efficacy is useful in improving evidence-based practice in the treatment of binge eating disorder and bulimia nervosa and may also have implications in the training of clinicians. The study also demonstrated that the use of a range of knowledge translation strategies are valuable in enhancing clinician adherence to evidence-based practice. Further research with direct measures of treatment fidelity is needed to clarify these findings.

https://ift.tt/2Pn1JxC

A retrospective intercenter comparison of two surgical protocols through the dental arch relationship of 5- to 6-year-old unilateral cleft patients

Abstract

Objectives

The objectives of this retrospective equivalence trial were to assess the dental arch relationship of 5- to 6-year-old patients with unilateral cleft lip and palate (UCLP) treated in two specialized cleft centers with a different surgical protocol using the 5-Year-Olds' Index and the modified Huddart/Bodenham scoring system, and to determine the correlation between these two scoring indices.

Materials and methods

The dental arch relationship of seventy-three 5- to 6-year-old patients with complete UCLP was evaluated on plaster casts using the 5-Year-Olds' Index and the modified Huddart/Bodenham scoring system. The sagittal occlusion, overbite, and overjet were also recorded. Inter- and intra-examiner agreement was determined using Intraclass Correlation Coefficients.

Results

A good to very good inter- and intra-examiner agreement was found. No significant mean difference in outcome based on the 5-Year-Olds' Index, the modified Huddart/Bodenham scoring system, overjet, or overbite was detected. For mean difference in sagittal occlusion, the hypothesis that both centers are clinically equivalent was confirmed. A strong negative correlation (r_s = − 0.832) between the 5-Year-Olds' Index and the modified Huddart/Bodenham scoring system was found.

Conclusions

The dental arch relationship of 5- to 6-year-old unilateral cleft patients treated in two Belgian cleft centers is clinically equivalent based on sagittal occlusion, despite substantial differences in their treatment protocol. Clinical equivalence for other parameters was not confirmed. There is a strong correlation between the 5-Year-Olds' Index and the modified Huddart/Bodenham scoring system.

Clinical relevance

A well-implemented treatment protocol for cleft patients is of the utmost importance, but case load and skill of the surgeon are also important factors for the quality of the results.

https://ift.tt/2NBMpN7

Correction: Environmental Risk Factors for Type 1 Diabetes Mellitus Development

Exp Clin Endocrinol Diabetes
DOI: 10.1055/a-0723-6799

[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
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The Untold Story of the First Hand Transplant: Dedicated to the Memory of one of the Great Minds of the Ecuadorian Medical Community and the World

J reconstr Microsurg
DOI: 10.1055/s-0038-1668535

Background In 1964, faced with the challenge of traumatic amputation, a team of surgeons at Clinica Guayaquil was convinced that the transplantation of a hand could significantly improve function and quality of life for the recipient. With a current but basic understanding of immunosuppression, the surgeons identified a recipient and waited for the correct donor. A human hand transplant had never been performed to date. Methods The surgeons' criteria for the recipient included a young healthy individual who had sustained a traumatic amputation at the distal forearm level with full motion of the proximal joints. Communication with receiving hospitals and military facilities identified what they perceived to be a feasible donor for an allograft transplantation. Consent was obtained from the family in conjunction with the local military medical authorities and the clergy. Iced saline solution and Heparin irrigation were to be used to prepare the donor extremity. The immunosuppression regimen, limited at the time, consisted only of intravenous cortisone, Imuran, and a single dose of radiation. Results A member of the Ecuadorian marine sustained a limited blast injury that amputated his dominant hand but spared the forearm. He was transferred to the emergency department of Clinica Guayaquil. A donor who had recently died in a nearby hospital was identified not long after. A successful technical surgical transplantation was achieved. Consultants from major hospitals around the world (including Peter Bent Brigham Hospital) convened at the patient's bedside to observe the results. Despite all efforts, the patient suffered an irreversible rejection at 21 days post-transplant. Conclusions This was the first allograft transplantation of a hand. The surgeons embarked on an intervention never tried before, firmly believing that better function and quality of life would result. The bravery of this surgical team was commendable. This early surgical endeavor opened the way for future successes in transplant surgery today.
[...]

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

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Response to Letter to Editor “Optical coherence tomography (OCT) findings in obstructive sleep apnea“ by Piotr Kanclerz

We thank the reader for his comments concerning our review on obstructive sleep apnea syndrome (OSAS) and the eye (especially the retina and the optic nerve). Piotr Kanclerz reviewed the studies reporting the OCT findings of the optic nerve in OSAS subjects. Most particularly, the authors cited the following reference1 "Grzybowski A, Ascaso FJ, Mateo J, Cabezón L, Casas P. Other Neurological Disorders: Migraine, Neurosarcoidosis, Schizophrenia, Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS).

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“Medical Emergencies in the dental practice – Management Requirements and International Practitioner Proficiency. A Scoping Review”

Australian Dental Journal, Volume 0, Issue ja, -Not available-.


https://ift.tt/2MJg6z8

Scholar : Experimental and Therapeutic Medicine - Volume:16 Number:4

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TABLE OF CONTENTS October-2018 Volume 16 Issue 4

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MicroRNA‑124 inhibits cell proliferation, invasion and migration by targeting CAV1 in bladder cancer Wandan Zhou, Leye He, Yinbo Dai, Yichuan Zhang, Jinrong Wang, Bin Liu View Abstract ❯
CYP24A1 depletion facilitates the antitumor effect of vitamin D3 on thyroid cancer cells Ning Hu, Hao Zhang View Abstract ❯
MERS associated with bacterial translocation in a pediatric patient with congenital portal vein hypoplasia: A case report George Imataka, Takeshi Yamaguchi, Junpei Ishii, Kei Ogino, Kentaro Okamoto, Takashi Tsuchioka, Shigemi Yoshihara View Abstract ❯
Cytotoxicity of local anesthetics on rabbit adipose‑derived mesenchymal stem cells during early chondrogenic differentiation Tao Wu, Zhaohong Shi, Haixin Song, Yangzheng Li, Jian‑Hua Li View Abstract ❯
Inhibition of endogenous hydrogen sulfide production exacerbates the inflammatory response during urine‑derived sepsis‑induced kidney injury Huili Qiu, Xian Chen, Zhigang Luo, Liwen Zhao, Tao Zhang, Ning Yang, Xiangyang Long, Huang Xie, Jun Liu, Wujun Xu View Abstract ❯
Effect of parathyroid hormone on cardiac function in rats with cardiomyopathy Gang‑Yong Wu, Ting Wu, Bai‑Da Xu, Yi‑Cheng Shi, Zhi‑Yuan Cheng, Xiao Zhang, Xiao Wang, Gang‑Jun Zong View Abstract ❯
The function of MMP‑28/TGF‑β induced cell apoptosis in human glioma cells Xuepeng Wang, Xi Chen, Lin Sun, Xiaoli Bi, Haitao He, Lei Chen, Jinfeng Pang View Abstract ❯
Effect of abnormal GpG methylation in the second trimester of pregnancy on adverse health risk of offspring Yu Shi, Mingxing Liu, Xiaolin Long, Dunjin Chen, Haiyan Zheng, Shiling Chen View Abstract ❯
A comparison of CD105 and CD31 expression in tumor vessels of hepatocellular carcinoma by tissue microarray and flow cytometry Hongyan Qian, Liping Yang, Wenjing Zhao, Haizhen Chen, Song He View Abstract ❯
Effect of simvastatin on expression of VEGF and TGF-β1 in atherosclerotic animal model of type 2 diabetes mellitus Haiyan Wang, Jian Li, Xudong Fu, Yu Liu, Qinghua Xu, Lili Sang View Abstract ❯
Application of karyotype analysis combined with BACs-on-Beads for prenatal diagnosis Yuan Fang, Guangming Wang, Lize Gu, Jingjing Wang, Feng Suo, Maosheng Gu, Lingshan Gou View Abstract ❯
Chlorogenic acid in the oxidative stress injury triggered by Shuang‑Huang‑Lian injection Wen‑Yuan Du, Ying Xiao, Jian‑Jing Yao, Zhe Hao, Yu‑Bin Zhao View Abstract ❯
Fibroblast growth factor receptor 1 antagonism attenuates lipopolysaccharide‑induced activation of hepatic stellate cells via suppressing inflammation Dayong Lou, Jibo Han, Liqin Zhou, Huanjie Ma, Jianjiang Xv, Junwei Shou, Zhixiu Xu, Liqin Jiang, Yuanyuan Qian View Abstract ❯
Expression of c-Myc and Beclin-1 in skin of rats after burn Caihong Li, Yuping Liu, Hongjuan Liu View Abstract ❯
Exercise intervention alleviates nerve injury by the suppression of inflammatory mediator expression via the TLR4/NF‑κB signaling pathway Yan Sun, Jie Qiong Liu, Feng Tian View Abstract ❯
Tanshinone IIA inhibits cell proliferation and tumor growth by downregulating STAT3 in human gastric cancer Yongjun Zhang, Shuguang Guo, Jian Fang, Bojian Peng, Yuan Zhang, Tiansheng Cao View Abstract ❯
Thiazolidinedione induces a therapeutic effect on hepatosteatosis by regulating stearoyl‑CoA desaturase‑1, lipase activity, leptin and resistin Hessah Mohammed Al‑Muzafar, Kamal Adel Amin View Abstract ❯
Impact of phosphorylated insulin‑like growth factor‑1 receptor on the outcome of breast cancer patients and the prognostic value of its alteration during neoadjuvant chemotherapy Liang Li, Shuchen Liu, Liyuan Liu, Zhongbing Ma, Man Feng, Chunmiao Ye, Wenzhong Zhou, Yongjiu Wang, Lu Liu, Fei Wang, Lixiang Yu, Fei Zhou, Yujuan Xiang, Shuya Huang, Qinye Fu, Qiang Zhang, Dezong Gao, Zhigang Yu View Abstract ❯
Propofol‑induced vasodilation of mesenteric arterioles via BKCa channel and gap junction Hui‑Juan Wan, Yang Wang, Jun‑Qiang Si, Li Li View Abstract ❯
Co‑culture of bone marrow stromal cells and chondrocytes in vivo for the repair of the goat condylar cartilage defects Hao Sun, Yue Huang, Lei Zhang, Biao Li, Xudong Wang View Abstract ❯
Eosinophilic cystitis in children: A case report Jun He, Feng Ning, Lei Tu, Jianjun Hu, Weijian Chen, Yaowang Zhao View Abstract ❯
Potential use of compounds from sea cucumbers as MDM2 and CXCR4 inhibitors to control cancer cell growth Teresa Liliana Wargasetia, Sofy Permana, Nashi Widodo View Abstract ❯
Inhibition of RKIP aggravates thioacetamide‑induced acute liver failure in mice Xing Lin, Jinbin Wei, Jinlan Nie, Facheng Bai, Xunshuai Zhu, Lang Zhuo, Zhongpeng Lu, Quanfang Huang View Abstract ❯
Effects of glucocorticoids combined with probiotics in treating Crohn's disease on inflammatory factors and intestinal microflora Hui Su, Qian Kang, Haihong Wang, Hui Yin, Linghui Duan, Yuli Liu, Ruying Fan View Abstract ❯
The expression and correlation between chemokine CCL7 and ABCE1 in non‑small cell lung cancer Zhuo Wu, Ye Tian, Qian Yu, Hongyuan Li, Zhiqiang Tian, Hongfang Jiang, Dali Tian, Xueying Yang View Abstract ❯
Protective effects of extracellular polymeric substances from Aphanizomenon flos‑aquae on neurotoxicity induced by local anesthetics Xing Xue, Ying Lv, Yufang Leng, Yan Zhang View Abstract ❯
Ginsenoside Rb1 administration attenuates focal cerebral ischemic reperfusion injury through inhibition of HMGB1 and inflammation signals Anxin Liu, Weiwei Zhu, Lirui Sun, Guangming Han, Huiping Liu, Zhaoyu Chen, Li Zhuang, Wen Jiang, Xia Xue View Abstract ❯
Correlation between controlled lung collapse and early lung injury in dogs Gaowang Liu, Hongyan Wang, Xin Lu, Xianfeng Ma, Ming Xiao, Pan Xiao, Yan Wei, Miao Yang, Xueying Yang, Xiao Yan, Aixing Zhang, Rui Li, Jianjun Tang, Xiaojun Liu, Yating Zhang, Jinfang Xiao View Abstract ❯
Overexpression of TRIM44 is an independent marker for predicting poor prognosis in epithelial ovarian cancer Shuang Liu, Hexuan Yin, Hongying Ji, Jiaqi Zhu, Rong Ma View Abstract ❯
Effect of autophagy‑associated proteins on the arecoline‑induced liver injury in mice Xia Wang, Xinhong Song, Youjiao Si, Jikai Xia, Bin Wang, Peiyuan Wang View Abstract ❯
Correlation of CXCR4/CXCR7 signaling pathway with pre-eclampsia Zhi Zheng, Hongping Zhang, Jianqiong Zheng, Haiying Chen, Xiaoen Cao View Abstract ❯
Correlation of CCR5 and NLRP3 gene polymorphisms with renal damage due to hepatitis C virus-related cryoglobulinemia Mengjun Wang, Qiuli Liu, Chunhua Liu View Abstract ❯
Masquelet induced membrane technique for treatment of rat chronic osteomyelitis Tao Cui, Junpeng Li, Ping Zhen, Qiuming Gao, Xiaohai Fan, Chuangbing Li View Abstract ❯
Values of serum LDL and PCT levels in evaluating the condition and prognosis of acute cerebral infarction Xianliang Meng, Renying Wen, Xiao Li View Abstract ❯
Plasminogen activator inhibitor‑1 serves an important role in radiation‑induced pulmonary fibrosis Sachiko Shioya, Takeshi Masuda, Tadashi Senoo, Yasushi Horimasu, Shintaro Miyamoto, Taku Nakashima, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori View Abstract ❯
An exploration on the influence of positive simple thyroid peroxidase antibody on female infertility Xianping Wang, Xufeng Ding, Xiao Xiao, Fang Xiong, Rui Fang View Abstract ❯
Effect of Wnt signaling pathway on pathogenesis and intervention of neuropathic pain Yu Zhao, Zhanyun Yang View Abstract ❯
Clinical efficacy of meniscus plasty under arthroscopy in middle-aged and elderly patients with meniscus injury Yuhui Shi, Zhigang Tian, Lifan Zhu, Jincai Zeng, Rong Liu, Jianxin Zhou View Abstract ❯
Bacterial distribution, changes of drug susceptibility and clinical characteristics in patients with diabetic foot infection Ling Liu, Zhihui Li, Xinxin Liu, Shan Guo, Limin Guo, Xuelian Liu View Abstract ❯
Diagnostic value of platelet‑derived microparticles in pulmonary thromboembolism: A population‑based study Minlian Wang, Yingyun Fu, Lan Xu, Lu Xiao, Yongjian Yue, Shengguo Liu, Qijun Huang, Shulin Li, Yazhen Li View Abstract ❯
Analysis of gene expression and functional changes of adrenal gland in a rat model of kidney yang deficiency syndrome treated with Sini decoction Nong Tang, Lihong Liu, Hua Qiu, Wei Shi, Dewen Mao View Abstract ❯
Sedated gastroscopy improves detection of gastric polyps Meng‑Jun Chen, Wei Wu, Shuang Pan, Chun‑Jing Lin, Le‑Mei Dong, Zhou‑Feng Chen, Jian‑Sheng Wu, Zhi‑Ming Huang View Abstract ❯
Sitagliptin reduces insulin resistance and improves rat liver steatosis via the SIRT1/AMPKα pathway Tian Shen, Bilin Xu, Tao Lei, Lin Chen, Cuiping Zhang, Zhenhua Ni View Abstract ❯
MicroRNA‑663b promotes cell proliferation and epithelial mesenchymal transition by directly targeting SMAD7 in nasopharyngeal carcinoma Meirong Wang, Min Jia, Kun Yuan View Abstract ❯
Association of OGG1 and DLST promoter methylation with Alzheimer's disease in Xinjiang population Wei Chen, Xiaohui Zhou, Yali Duan, Ting Zou, Guili Liu, Xiuru Ying, Qinwen Wang, Shiwei Duan View Abstract ❯
Radioprotective effect of lactoferrin in mice exposed to sublethal X‑ray irradiation Li Feng, Jianguo Li, Ling Qin, Dan Guo, Hongyu Ding, Daping Deng View Abstract ❯
Establishment and characterization of McA‑RH7777 cells using virus‑mediated stable overexpression of enhanced green fluorescent protein Wei Zhang, Sheng Qian, Guowei Yang, Liang Zhu, Bo Zhou, Xudong Qu, Zhiping Yan, Rong Liu, Jianhua Wang View Abstract ❯
Evaluation of the diagnostic value of the immunoblotting and ELISA tests using recombinant Em18 antigen in human alveolar echinococcosis from Xingjiang China Xiao‑Juan Bi, Yin‑Mei Shao, Liang Li, Yan Wang, Chuan‑Shan Zhang, Guo‑Dong Lü, Tuerganaili Aji, Jun Li, Wen‑Bao Zhang, Hao Wen, Ren‑Yong Lin View Abstract ❯
Characteristics of bone marrow cells in 107 patients with juvenile idiopathic arthritis: A retrospective study Di Zhu, Jihua Zhong, Yiwei Zhang, Fangyuan Chen View Abstract ❯
Predicative values of C‑reactive protein for the therapeutic effects of ulinastatin combined with somatostatin in severe acute pancreatitis and for the severity of gastrointestinal failure Yinjia Wang, Li Li View Abstract ❯
Menaquinone‑4 modulates the expression levels of calcification‑associated factors to inhibit calcification of rat aortic vascular smooth muscle cells in a dose‑dependent manner Liwen Cui, Jinsheng Xu, Junxia Zhang, Muqing Zhang, Shenglei Zhang, Yaling Bai View Abstract ❯
Congenital anomalies in infants conceived by infertile women through assisted reproductive technology: A cohort study 2004‑2014 Ying Han, Haining Luo, Yunshan Zhang View Abstract ❯
Effect of luteolin on the methylation status of the OPCML gene and cell growth in breast cancer cells Xinmin Dong, Jian Zhang, Fan Yang, Jing Wu, Rui Cai, Tian Wang, Jiren Zhang View Abstract ❯
SPARCL1 suppresses the proliferation and migration of human ovarian cancer cells via the MEK/ERK signaling Yan Ma, Yuan Xu, Li Li View Abstract ❯
Longitudinal behavioral and fMRI‑based assessment of inhibitory control in heroin addicts on methadone maintenance treatment Jian‑Jun Ye, Wei Li, Dong‑Sheng Zhang, Qiang Li, Jia Zhu, Jia‑Jie Chen, Yong‑Bin Li, Xue‑Jiao Yan, Jie‑Rong Liu, Xuan Wei, Ya‑Rong Wang, Wei Wang View Abstract ❯
Regulation of mPGES‑1 composition and cell growth via the MAPK signaling pathway in jurkat cells Yi‑Qing Li, Jiao‑Ting Chen, Song‑Mei Yin, Da‑Nian Nie, Zhi‑Yuan He, Shuang‑Feng Xie, Xiu‑Ju Wang, Yu‑Dan Wu, Jie Xiao, Hong‑Yun Liu, Jie‑Yu Wang, Wen‑Juan Yang, Li‑Ping Ma View Abstract ❯
Hsa_circ_0033155: A potential novel biomarker for non‑small cell lung cancer Xiaohua Gu, Gang Wang, Hui Shen, Xiaoyun Fei View Abstract ❯
Echinocandins for Pneumocystis jirovecii pneumonia in non‑HIV patients: A case report Hui‑Bin Huang, Jing‑Min Peng, Bin Du View Abstract ❯
Resveratrol ameliorates sepsis‑induced acute kidney injury in a pediatric rat model via Nrf2 signaling pathway Yan Wang, Fenling Feng, Minna Liu, Jiahong Xue, Huimei Huang View Abstract ❯
Oscillatory positive expiratory pressure treatment in lower respiratory tract infection Yingmeng Ni, Lin Ding, Youchao Yu, Ranran Dai, Hong Chen, Guochao Shi View Abstract ❯
MicroRNA‑6852 suppresses cell proliferation and invasion via targeting forkhead box J1 in gastric cancer Hui Yu, Jing Zhang, Qu Wen, Yi Dai, Wanli Zhang, Fen Li, Juan Li View Abstract ❯
Identification of a missense mutation in MIP gene via mutation analysis of a Guangxi Zhuang ethnic pedigree with congenital nuclear cataracts Zhou Zhou, Li Li, Lu Lu, Li Min View Abstract ❯
Regulatory role of microRNA‑185 in the recovery process after ankle fracture Deping Sun, Juntao Liu, Qingpeng Shi, Haibo Mu, Dongsheng Zhou View Abstract ❯
Cellular signaling pathways regulating β‑cell proliferation as a promising therapeutic target in the treatment of diabetes (Review) Wen‑Juan Jiang, Yun‑Chuan Peng, Kai‑Ming Yang View Abstract ❯
Capsid protein Vp1 from chlamydiaphage φCPG1 effectively alleviates cytotoxicity induced by Chlamydia trachomatis Jie Ren, Yuanli Guo, Lili Shao, Yuanjun Liu, Quanzhong Liu View Abstract ❯
Oxidative status of cardinal ligament in pelvic organ prolapse Gui Fang, Li Hong, Cheng Liu, Qing Yang, Qifan Zhang, Yang Li, Bingshu Li, Debin Wu, Wenying Wu, Hua Shi View Abstract ❯
Combination of magnetic resonance imaging and targeted contrast agent for the diagnosis of myocardial infarction Jiangjun Qin, Shuchang Zhou, Zhiwei Li, Yinan Chen, Qun Qin, Tao Ai View Abstract ❯
Long noncoding RNA TCONS_00024652 regulates vascular endothelial cell proliferation and angiogenesis via microRNA‑21 Muertiza Halimulati, Bagedati Duman, Julaiti Nijiat, Abudoureyimu Aizezi View Abstract ❯
Mixed lineage kinase‑4 promotes gastric carcinoma tumorigenesis through suppression of the c‑Jun N‑terminal kinase signaling pathway Yu Xi, Jianhua Niu, Dongmei Li, Jiagen He, Le Qin, Xinyu Peng View Abstract ❯
Combined effects of Lenvatinib and iodine‑131 on cell apoptosis in nasopharyngeal carcinoma through inducing endoplasmic reticulum stress Guoyu Wang, Juhua Zhuang, Jing Ni, Ying Ye, Saifei He, Wei Xia View Abstract ❯
Nrf2‑dependent antioxidant response mediated the protective effect of tanshinone IIA on doxorubicin‑induced cardiotoxicity Zhaohui Guo, Miao Yan, Lei Chen, Pingfei Fang, Zhihua Li, Zimeng Wan, Sisi Cao, Zhenyan Hou, Shanshan Wei, Wenqun Li, Bikui Zhang View Abstract ❯
Sericin enhances the insulin‑PI3K/AKT signaling pathway in the liver of a type 2 diabetes rat model Chengjun Song, Donghui Liu, Songhe Yang, Luyang Cheng, Enhong Xing, Zhihong Chen View Abstract ❯
Development and evaluation of LAMP, CPA and IMSA methods for rapid detection of the AML1/ETO fusion gene in acute myeloid leukemia Zhigang Yang, Wenxin Liu, Haiyan Liang, Ruiting Wen, Yuming Zhang View Abstract ❯
Subarachnoid hemorrhage enhances the expression of TDP‑43 in the brain of experimental rats and human subjects Tibiao He, Yuchun Zuo, Kauthar Ai‑Zakwani, Jing Luo, Haixia Zhu, Xiao‑Xin Yan, Fei Liu View Abstract ❯
Silencing FOXC1 inhibits growth and migration of human oral squamous cell carcinoma cells Zhongjun Liu, Shuaimei Xu, Hongxing Chu, Yu Lu, Peiyan Yuan, Xiongqun Zeng View Abstract ❯
Expression levels of IL-15 and IL-17 in synovial fluid of rheumatoid arthritis animal model Yi Jin, Xiao Chen, Zongyan Gao, Ke Liu, Yi Hou, Jia Zheng View Abstract ❯
Effects of tirofiban on stent thrombosis, Hs-CRP, IL-6 and sICAM-1 after PCI of acute myocardial infarction Yuqing Zhang, Tingguo Shao, Lei Yao, Hong Yue, Zhiyu Zhang View Abstract ❯
Local injection of dexamethasone helping to prevent lower back pain after epidural delivery analgesia Zhaoxia Yang, Lanlan Liu, Jinmei Mu, Wenchen Guo, Shunrong Li, Yanyan Jing, Yanyan Liu View Abstract ❯
Analysis on the level of IL-6, IL-21, AMH in patients with auto-immunity premature ovarian failure and study of correlation Shulan Sun, Hong Chen, Xiaoxia Zheng, Chuanyan Ma, Ruiqin Yue View Abstract ❯
miR‑29b affects neurocyte apoptosis by targeting MCL‑1 during cerebral ischemia/reperfusion injury Zhi Huang, Lu Lu, Tianpeng Jiang, Shuai Zhang, Yaping Shen, Zhu Zheng, Ansu Zhao, Rui Gao, Rui Li, Shi Zhou, Jing Liu View Abstract ❯
Therapeutic effects of Salvia miltiorrhiza injection combined with telmisartan in patients with diabetic nephropathy by influencing collagen IV and fibronectin: A case-control study Jie-Ming Nie, Hai-Feng Li View Abstract ❯
Changes of TNF-α, PDGF and HA in nasal secretions and olfactory function of patients with chronic sinusitis before and after endoscopic sinus surgery Linqi Wei, Yonghong Zhang, Huazhang Tan View Abstract ❯
Plasma miR‑136 can be used to screen patients with knee osteoarthritis from healthy controls by targeting IL‑17 Lei Wan, Qiang Zhao, Gang Niu, Tai Xiang, Cuilei Ding, Shijie Wang View Abstract ❯
Evaluation of drug release from paclitaxel + hirudin‑eluting balloons and the resulting vascular reactivity in healthy pigs Xian Wang, Hongmei Li, Xiaoting Sun, Xiaohang Wang, Gangyin Wang View Abstract ❯
Health risk behaviors among high school and university adolescent students Christina Tsitsimpikou, Konstantinos Tsarouhas, Fotini Vasilaki, Petros Papalexis, Georgios Dryllis, Athanasios Choursalas, Demetrios A. Spandidos, Aristides Tsatsakis, Ekaterina Charvalos, Flora Bacopoulou View Abstract ❯
Thymosin β4 promotes glucose‑impaired endothelial progenitor cell function via Akt/endothelial nitric oxide synthesis signaling pathway Fuyu Qiu, Jiale Song, Xukun Bi, Meihui Wang, Yanbo Zhao, Guosheng Fu View Abstract ❯
Claudin1 promotes the proliferation, invasion and migration of nasopharyngeal carcinoma cells by upregulating the expression and nuclear entry of β‑catenin Xin Wu, Jianghong Xiao, Chong Zhao, Chengjian Zhao, Zhongcheng Han, Feng Wang, Yuqiong Yang, Yu Jiang, Fang Fang View Abstract ❯
Establishment and evaluation of a Beagle model of grade III pancreatic trauma Hanjing Gao, Qing Song, Faqin Lv, Bin Shi, Pengfei Wang, Yiru Wang, Yan Zhang, Li Yang, Yukun Luo, Xingguo Mei, Jie Tang View Abstract ❯
Guide sheath‑assisted ureteroscope lithotripsy for upper ureteral calculi: An observational study on 81 cases Jia‑Sheng Hu, Guo‑Hai Xie, He‑Sheng Yuan, Guan‑Lin Liu, Xiao‑Long Jia, Zhong Zheng, Yue Cheng View Abstract ❯
Eugenol protects the transplanted heart against ischemia/reperfusion injury in rats by inhibiting the inflammatory response and apoptosis Wei Fen, Longyu Jin, Qianyi Xie, Lihua Huang, Zhibin Jiang, Ying Ji, Chunyun Li, Linfei Yang, Dianjun Wang View Abstract ❯
AngII induces HepG2 cells to activate epithelial‑mesenchymal transition Minghua Qi, Yuanping Zhou, Jikui Liu, Xi Ou, Minghua Li, Xia Long, Jing Ye, Guangyin Yu View Abstract ❯
Radial extracorporeal shock wave therapy promotes osteochondral regeneration of knee joints in rabbits Hui Qi, Shaofeng Jin, Chunyang Yin, Lei Chen, Lei Sun, Yajun Liu View Abstract ❯
Sulbactam enhances the in vitro activity of sitafloxacin against extensively‑drug resistant Acinetobacter baumannii Nannan Xu, Gang Wang, Yan Leng, Xiaomeng Dong, Fengzhe Chen, Quantai Xing View Abstract ❯
Effects of different CYP2C19 genotypes on prognosis of patients complicated with atrial fibrillation taking clopidogrel after PCI Qifeng Zhang, Zhixiong Zhong, Bin Li, Zhengxian Liao, Pingsen Zhao, Zhuolian Ye, Xuebo He, Hao Wang, Wenhao Chen, Junping Huang View Abstract ❯
Aconitine‑induced cardiac arrhythmia in human induced pluripotent stem cell‑derived cardiomyocytes Feng Zhang, Lin Cai, Jing Zhang, Xueyan Qi, Chengzhi Lu View Abstract ❯
Naringin promotes cellular chemokine synthesis and potentiates mesenchymal stromal cell migration via the Ras signaling pathway Feng Lin, Yuan Zhu, Gangfeng Hu View Abstract ❯
Aerobic exercise‑stimulated Klotho upregulation extends life span by attenuating the excess production of reactive oxygen species in the brain and kidney Naichun Ji, Jing Luan, Fengrui Hu, Yirong Zhao, Bosen Lv, Wen Wang, Meng Xia, Xin Zhao, Kejing Lao View Abstract ❯
USF1 promotes the development of knee osteoarthritis by activating the NF‑κB signaling pathway Xiandong Song, Min Zhu, Hao Li, Bo Liu, Zhaowei Yan, Weican Wang, Hongyi Li, Jiping Sun, Shixing Li View Abstract ❯
Retinoic acid receptor α expression exerts an anti‑apoptosis effect on PC12 cells following oxygen‑glucose deprivation Wanliang Dong, Yuankun Zhang View Abstract ❯
Association between the effect of controlled fluid resuscitation on massive hemorrhage and expression of human neutrophil lipocalin Jie-Yang Yu, Jia-Hua Peng, Li Hui, Hui-Quan Huang, Ming-Hua Tan, Guo Jian View Abstract ❯
Comprehensive analysis of gene expression profiles associated with proliferative diabetic retinopathy Meng‑Ting Gong, Wen‑Xing Li, Qing Zhang, Wen‑Wen Lv, Zheng‑Hong He, Shu‑Li Zhou, Hui Zhang, Jing Wang, Kan He View Abstract ❯
Expression and localization of nuclear factor erythroid 2‑related factor 2 in the ovarian tissues of mice at different ages Namita Sindan, Adheesh Bhandari, Yu Zhao, Xiaosheng Lu, Jieqiang Lv View Abstract ❯
Therapeutic effects of new-type hydraulic delivery vertebroplasty, balloon kyphoplasty and conventional pusher-type vertebroplasty on single segmental osteoporotic vertebral compression fracture Ping Zhang, Zhi-Hong Zhong, Hao-Tao Yu, Wei Zhou, Jian Li View Abstract ❯
Clinical treatment of traumatic optic neuropathy in children: Summary of 29 cases Min Chen, Yan Jiang, Jisheng Zhang, Na Li View Abstract ❯
Downregulated caveolin‑1 expression serves a potential role in coronary artery spasm by inducing nitric oxide production in vitro Xingmei Cao, Zhishuai Ye, Mingyu Jin, Shuai Yan, Xiantao Song, Rongchong Huang View Abstract ❯
Effects of atrial fibrillation on complications and prognosis of patients receiving emergency PCI after acute myocardial infarction Yingchun Zhang, Lingzhi Zhang, Hongzhi Zheng Zheng, Hongfen Chen View Abstract ❯
Effects of captopril and valsartan on ventricular remodeling and inflammatory cytokines after interventional therapy for AMI Xiaona Gong, Raorao Zhou, Qinhao Li View Abstract ❯
Regulatory effect of immunosuppressive agents in mice with renal ischemia reperfusion injury Wei Zhang, Junpeng Zhao, Fuyuan Cao, Shumin Li View Abstract ❯
De novo unbalanced translocation t(15;22)(q26.2;q12) with velo‑cardio‑facial syndrome: A case report and review of the literature Cristina Gug, Delia Huțanu, Monica Vaida, Gabriela Doroş, Cristina Popa, Ramona Stroescu, Gheorghe Furău, Cristian Furău, Laura Grigoriță, Ioana Mozos View Abstract ❯
The influence of dexmedetomidine on remifentanil‑induced hyperalgesia and the sex differences Haidi Qiu, Zhe Sun, Fathima Shadhiya, Renuka Arulthas, Gita Vishnu Priya, Pariyatha Christopher, Zulaihat Muhammad, Yonghao Yu View Abstract ❯
Resolvin D1 inhibits the proliferation of lipopolysaccharide‑treated HepG2 hepatoblastoma and PLC/PRF/5 hepatocellular carcinoma cells by targeting the MAPK pathway You Lu, Qingyu Xu, Guowen Yin, Weidong Xu, Hao Jiang View Abstract ❯
MicroRNA‑744 promotes cell apoptosis via targeting B cell lymphoma‑2 in gastric cancer cell line SGC‑7901 Jixiang Liu, Yanlei Wei, Shouyong Li, Yujuan Li, Hongxiu Liu, Jingmei Liu, Xinxing Zhu View Abstract ❯
Percutaneous kyphoplasty treatment evaluation for patients with Kümmell disease based on a two‑year follow‑up Yong‑Hui Xia, Feng Chen, Liang Zhang, Gang Li, Zhi‑Yu Tang, Bo Feng, Ke Xu View Abstract ❯
Intrapancreatic accessory spleen: Evaluation with CT and MRI Qianjiang Ding, Zhihao Ren, Jianhua Wang, Xiaolong Ma, Jian Zhang, Gaofeng Sun, Changjing Zuo, Hao Gu, Hui Jiang View Abstract ❯
Reduced peripheral blood miR‑140 may be a biomarker for acute lung injury by targeting Toll‑like receptor 4 (TLR4) Xinyi Li, Jin Wang, Huisheng Wu, Peipei Guo, Chengyao Wang, Yanlin Wang, Zongze Zhang View Abstract ❯
Reduced expression of microRNA‑199a‑3p is associated with vascular endothelial cell injury induced by type 2 diabetes mellitus Hui Wang, Zhengxia Wang, Qingbin Tang View Abstract ❯
Protective role of propofol in endometriosis and its mechanism Shuo Feng, Yingui Sun View Abstract ❯
Evaluation of the potential of chicoric acid as a natural food antioxidant Xueliang Zhu, Fenghong Huang, Xia Xiang, Min Fan, Tingtao Chen View Abstract ❯
Deficiency of hypoxia inducible factor‑1α promoted progression of diabetic nephropathy with hypertension Yuejiang Jiao, Hongwei Jiang, Haibo Lu, Yiping Yang, Yanfang Zhang, Kun Zhang, Hui Liu View Abstract ❯
Ischemic colitis caused by polycythemia vera: A case report and literature review Shasha Zhang, Ruixue Lai, Xueqing Gao, Yufei Zhao, Yue Zhao, Jianhua Wu, Zhanjun Guo View Abstract ❯
Antiproliferation activities of NK4 on multiple myeloma Wenzhong Que, Huili Liu, Qinqin Yang, Shanghua Xu View Abstract ❯
Intravenous morphine titration vs. oral hydrocodone/acetaminophen for adults with lower extremity displaced fracture in an emergency department setting: A randomized controlled trial Zhengqi Pan, Yongjian Qi, Yinxian Wen, Liaobin Chen View Abstract ❯
MFN2 ameliorates cell apoptosis in a cellular model of Parkinson's disease induced by rotenone Yang Yang, Liu‑Jun Xue, Xiao Xue, Zhou Ou, Teng Jiang, Ying‑Dong Zhang View Abstract ❯
Effect of exercise on bone in poorly controlled type 1 diabetes mediated by the ActRIIB/Smad signaling pathway Jin Yang, Lijun Sun, Xiushan Fan, Bo Yin, Yiting Kang, Liang Tang, Shucheng An View Abstract ❯
Combination treatment of captopril and prazosin to treat patients with gestational hypertension Bo Hong, Xiang Ding, Hongmei Iia, Jianmei Zhang View Abstract ❯
miRNA‑146a attenuates inflammation in an in vitro spinal cord injury model via inhibition of TLR4 signaling Ying Tan, Longtan Yu, Chunming Zhang, Kebing Chen, Junfan Lu, Lei Tan View Abstract ❯
Clinical characteristics of occluded culprit arteries and collaterals in patients with non‑ST‑segment elevation myocardial infarction and impact on clinical outcomes Hui‑Jeong Hwang, Chang‑Bum Park, Jin‑Man Cho, Eun‑Sun Jin, Il Suk Sohn, Dong‑Hee Kim, Chong‑Jin Kim View Abstract ❯
Hesperidin protects against IL‑1β‑induced inflammation in human osteoarthritis chondrocytes Zhaozong Fu, Zhongxian Chen, Qinghua Xie, Hongjun Lei, Shanshan Xiang View Abstract ❯
Dysregulated ICOS+ proinflammatory and suppressive regulatory T cells in patients with rheumatoid arthritis Hong‑Xia Wang, Xia Kang, Shuai Chu, Haixia Li, Xin Li, Xiaofeng Yin, Yu‑Rong Qiu, Weinan Lai View Abstract ❯
Effect of transient ulnar artery compression on radial artery diameter Mustafa Adem Yilmaztepe, Erdem Yilmaz View Abstract ❯
Protective role of fentanyl in lipopolysaccharide‑induced neuroinflammation in BV‑2 cells Jian Wang, Yingjie Jin, Jianchun Li View Abstract ❯
MicroRNA‑365 regulates the occurrence and immune response of sepsis following multiple trauma via interleukin‑6 Hui Gong, Xiaomin Sheng, Jianhua Xue, Dongbo Zhu View Abstract ❯
[Corrigendum] Expression and association of VEGF‑Notch pathways in infantile hemangiomas Shangbin Li, Guangqi Xu, Feng Gao, Jianhai Bi, Ran Huo View Abstract ❯

20-22 September, 2018, Metropolitan Hotel, Athens, Greece 23nd World Congress on Advances in Oncology & 22th International Symposium on Molecular Medicine 18-19 September 2018, Pre-Congress Workshop: 'MicroRNA Analysis'

28-30 March, 2019, Tawana Hotel, Bangkok, Thailand 23 rd International Symposium on Molecular Medicine

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