Cognitive Impairment Among Older Patients With Hematologic Cancers

To the Editor Dr Hshieh and colleagues found that, among 360 patients 75 years and older with hematologic cancer, 127 (35.3%) had probable executive dysfunction and 62 (17.2%) had probable impairment in working memory. Executive dysfunction was associated with worse survival only among patients who underwent intensive treatment, and impairment in working memory was associated with worse median (SD) survival in the overall cohort (10.9 [12.9] vs 12.2 [14.7] months; log-rank P < .001) and after adjusting for age, comorbidities, and disease aggressiveness (odds ratio, 0.26; 95% CI, 0.13-0.50). We believe that the results merit the following comments and discussion.

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