Psoriasis and Hidradenitis Suppurativa: A Large-scale Population-based Study

Publication date: Available online 28 November 2018

Source: Journal of the American Academy of Dermatology

Author(s): Khalaf Kridin, Michal Shani, Yochai Schonmann, Shani Fisher, Guy Shalom, Doron Comaneshter, Erez Batat, Arnon D. Cohen

Abstract

Background

The coexistence of psoriasis and hidradenitis suppurativa (HS) has been described, but the association between these conditions is yet to be firmly established.

Objectives

To study the association between psoriasis and HS using a large-scale real-life computerized database.

Methods

A cross-sectional study was conducted comparing the prevalence of HS among patients with psoriasis and among age-, sex- and ethnicity-matched control subjects.

Results

A total of 68,836 patients with psoriasis and 68,836 controls were included in the study. The prevalence of HS was increased in patients with psoriasis as compared to the control group (0.3% vs. 0.2%, respectively; OR, 1.8; 95% CI, 1.5-2.3; P<0.001). In a multivariate analysis adjusting for smoking, obesity, and other comorbidities, psoriasis was still associated with HS (OR, 1.8; 95% CI, 1.4-2.2; P<0.001). Patients with coexistent psoriasis and HS were significantly younger (39.0±15.7 vs. 42.6±21.2 years; P=0.015) and had a higher prevalence of obesity (35.1% vs. 25.3%; P=0.001) and smoking (58.5% vs. 37.3%; P<0.001) as compared to patients with psoriasis alone.

Limitations

Retrospective data collection.

Conclusions

A positive association was observed between HS and psoriasis. Further longitudinal observational studies are necessary to establish these findings in other study populations.

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