Publication date: Available online 12 November 2018
Source: Trends in Endocrinology & Metabolism
Author(s): Christine A. Mills, Alec G. Trub, Matthew D. Hirschey
Fatty acid synthesis (FAS) in mitochondria produces a key metabolite called lipoic acid. However, a new study by Van Vranken et al.[1] (Mol. Cell 2018;71:567–580) shows that mitochondrial FAS regulates the assembly of oxidative phosphorylation complexes, thereby functioning as a nutrient sensor for mitochondrial respiration.
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