Increased risk of incident thyroid diseases in people with psoriatic disease: A cohort study

Publication date: Available online 5 December 2018

Source: Journal of the American Academy of Dermatology

Author(s): Shu-Hui Wang, Jui Wang, Yu-Sheng Lin, Tao-Hsin Tung, Ching-Chi Chi

Abstract

Background

The association between psoriasis and thyroid diseases was unclear.

Objective

To examine the risk of thyroid diseases in psoriasis patients.

Methods

We used Taiwan's National Health Insurance Research Database to conduct a nationwide cohort study. We examined the hazard ratio (HR) and 95% confidence interval (CI) for incident thyroid diseases in relation to psoriasis and psoriatic arthritis.

Results

We identified 13,266 patients with psoriatic arthritis (psoriasis arthritis group), 149,576 with psoriasis alone (psoriasis group), and 162,842 nonpsoriatic controls. When compared to nonpsoriatic controls, the psoriasis arthritis and psoriasis groups had an increased risk of incident hyperthyroidism (adjusted HR: 1.32 (95% CI 1.07-1.65) and 1.22 (95% CI 1.11-1.33), respectively) and Grave's disease (adjusted HR: 1.38 (95% CI 1.07-1.79) and 1.26 (95% CI 1.13-1.41), respectively). Both groups had an increased risk of incident hypothyroidism (adjusted HR: 1.74 (95% CI1.34-2.27) and 1.38 (95% CI 1.23-1.56), respectively) and Hashimoto's thyroiditis (adjusted HR: 2.09 (95% CI 1.34-3.24) and 1.47 (95% CI 1.18-1.82), respectively).

Limitations

Lack of data on psoriasis severity.

Conclusion

People with psoriatic disease are associated with increased incident thyroid diseases including hyperthyroidism, hypothyroidism, thyroiditis, Grave's disease, and Hashimoto's thyroiditis. Endocrinological consultation may be considered when psoriasis patients present with thyroid symptoms.

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