Hyaluronic Acid-Povidone Iodine Compound Facilitates Diabetic Wound Healing in A Streptozotocin-induced Diabetes Rodent Model

Purpose: This study investigated whether the compound of hyaluronic acid (HA)-povidone iodine (PI) has the potential effectiveness to enhance diabetic wound healing. Materials and Methods: In this study, a dorsal skin defect (area, 6×5 cm) in a streptozotocin-induced diabetes rodent model was used. Seventy male Wistar rats were divided into 7 groups: normal control, diabetic control receiving no treatment, diabetic rat treated with HAL only (lower molecular weight 100 KDa); HAH only (higher molecular weight 1000 KDa); PI only (01%); HAL-PI compound; and HAH-PI compound groups. The wound dressing was changed twice per week. Wound healing progress was assessed once per 3 days post-operatively. Histologic examination was performed with hematoxylin and eosin staining. CD45, Ki-67, prolyl 4-hydroxylase (rPH), and vascular endothelial growth factor (VEGF) were evaluated with immunohistochemical (IHC) staining. Results: The results revealed that the wound area was significantly reduced in the HAH-PI treated diabetic rats as compared to the control group (P

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