Allergy

The presence of virus significantly associates with chronic rhinosinusitis disease severity

Allergy

Wed Mar 13, 2019 15:45

Dapsone‐ and nitroso dapsone‐specific activation of T‐cells from hypersensitive patients expressing the risk allele HLA‐B*13:01

Abstract Background Research into drug hypersensitivity associated with expression of specific HLA alleles has focussed on the interaction between parent drug and the HLA with no attention given to reactive metabolites. For this reason, we have studied HLA‐B*13:01‐linked dapsone hypersensitivity to (1) explore whether the parent drug and/or nitroso metabolite activates T‐cells and (2) determine whether HLA‐B*13:01 is involved in the response. Methods PBMC from 6 patients were cultured with...

Allergy

Thu Mar 07, 2019 15:45

Spectrogram for Childhood Asthma Detection and Analysis

Allergy

Wed Mar 06, 2019 15:28

Nrf2 activation via Keap1 deletion or Sulforaphane treatment reduces Ova‐induced sinonasal inflammation

Allergy

Wed Mar 06, 2019 15:19

Immune Pathomechanism and Classification of Drug Hypersensitivity

Abstract Drug hypersensitivity reactions (DHR) are based on distinct mechanisms and are clinically heterogeneous. Taking into account that also off target activities of drugs may lead to stimulations of immune or inflammatory cells, three forms of DHR were discriminated: The allergic‐immune mechanism relies on the covalent binding of drugs/chemicals to proteins, which thereby form new antigens, to which a humoral and/or cellular immune response can develop. In IgE mediated drug allergies a possible...

Allergy

Wed Mar 06, 2019 15:15

Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice

Abstract Coconut oil is used as a dietary oil worldwide, and its healthy effects are recognized by the fact that coconut oil is easy to digest, helps in weight management, increases healthy cholesterol and provides instant energy. Although topical application of coconut oil is known to reduce skin infection and inflammation, whether dietary coconut oil has any role in decreasing skin inflammation is unknown. In this study, we showed the impact of dietary coconut oil in allergic skin inflammation...

Allergy

Wed Mar 06, 2019 15:15

A Biodiversity Hypothesis

Abstract Biodiversity hypothesis states, that contact with natural environments enriches the human microbiome, promotes immune balance and protects from allergy and inflammatory disorders. We are protected by two nested layers of biodiversity, microbiota of the outer layer (soil, natural waters, plants, animals) and inner layer (gut, skin, airways). The latter inhabits our body and is colonized from the outer layer. Explosion of human populations along with cultural evolution are profoundly changing...

Allergy

Tue Mar 05, 2019 11:24