Publication date: Available online 6 April 2019Source: GeneAuthor(s): Josicelli Souza Crispim, Roberto Sousa Dias, Clara Nogueira Laguardia, Larissa Cristina Araújo, Jéssica Duarte da Silva, Pedro Marcus Pereira Vidigal, Maíra Paula de Sousa, Cynthia Canêdo da Silva, Mateus Ferreira Santana, Sérgio Oliveira de PaulaAbstractDesulfovibrio alaskensis is a Gram-negative bacterial species that belongs to the group of Sulphate Reducing Bacteria (SRB) and presents prophages in genomes, a common characteristic...
Sun Apr 07, 2019 16:58
Publication date: Available online 6 April 2019Source: GeneAuthor(s): Asma A. Swadi, Bassim I. Mohammad, Najah R. Hadi, Hayder A. Al-AubaidyAbstractThis study aims to investigate the different clinically relevant allele variants (allele frequencies) of CYP2D6 gene and to determine whether a specific genotype of CYP2D6 gene (based on genetic polymorphism "allelic types" and combination) have impact on metoprolol effectiveness (clinical outcome) in patients who have acute coronary syndrome (ACS). The...
Sun Apr 07, 2019 16:58
Publication date: Available online 6 April 2019Source: GeneAuthor(s): Xiaozhun Tang, Xiaoliang Huang, Duoping Wang, Ruogu Yan, Fen Lu, Chen Cheng, Yulan Li, Jian XuAbstractThyroid cancer is the most common type of endocrine tumor. The TNM classification remains a standard for treatment determination and predicting prognosis in thyroid cancer. The genes modules associated with the progression of papillary thyroid carcinoma (PTC) were not clear. We applied a weighted gene co-expression network analysis...
Sun Apr 07, 2019 16:58
Publication date: Available online 6 April 2019Source: GeneAuthor(s): Wenbo Lin, Changgui Shi, Weiheng Wang, Huiqiao Wu, Chen Yang, An Wang, Xiaolong Shen, Ye Tian, Peng Cao, Wen YuanAbstractObjectiveThe objective of our study was to verify the hypothesis that the expression of connective tissue growth factor (CTGF/CCN2), a key molecule essential for the maintenance of nucleus pulposus (NP) matrix homeostasis, is regulated by osmolarity and intracellular calcium in NP cells.MethodsGene and protein...
Sun Apr 07, 2019 16:58
Publication date: Available online 6 April 2019Source: GeneAuthor(s): Ying Fu, Pu Zhang, Hui Nan, Yiming Lu, Jun Zhao, Mengxiang Yang, Qingcui SongAbstractLncRNA CASC11 is a recently identified oncogenic lncRNA in colorectal cancer. This study aimed to investigate the role of lncRNA CASC11 in small cell lung cancer (SCLC). In the present study, expression levels of CASC11 and TGF-β1 were found to be positively and significantly correlated with the percentage of CDD133+ cells of SCLC cell lines. Plasma...
Sun Apr 07, 2019 16:58
Publication date: Available online 5 April 2019Source: GeneAuthor(s): Ricardo Vessoni Perez, Cleide Guimarães Machado, Daniele Pereira Santos-Bezerra, Sharon Nina Admoni, Thiago Andrade Patente, Maria Beatriz Monteiro, Ana Mercedes Cavaleiro, Márcia Silva Queiroz, Márcia Nery, Maria Lúcia Corrêa-GiannellaAbstractAimsGiven the participation of oxidative stress in the pathogenesis of diabetic complications, we evaluated, in type 1 diabetes (T1D) individuals, the association between diabetic retinopathy...
Sat Apr 06, 2019 15:31
Publication date: Available online 5 April 2019Source: GeneAuthor(s): Himansu Kumar, Krishnamoorthy Srikanth, Woncheol Park, Seung-Hoon Lee, Bong-Hwan Choi, Hana Kim, Yong-Min Kim, Eun-Seok Cho, Jin Hyoung Kim, Jang Hee Lee, Ji Yeon Jung, Gwang-woong Go, Kyung-Tai Lee, Jun-Mo Kim, Jungjae Lee, Dajeong Lim, Jong-Eun ParkAbstractLong non coding RNAs (lncRNA) have been previously found to be involved in important cellular activities like epigenetics, implantation, cell growth etc. in pigs. However,...
Fri Apr 05, 2019 14:11
Publication date: Available online 4 April 2019Source: GeneAuthor(s): Sook Kyung Do, Sun Ha Choi, Shin Yup Lee, Jin Eun Choi, Mi Jeong Hong, Hyo-Gyoung Kang, Won Kee Lee, Eung Bae Lee, Kyung Min Shin, Ji Yun Jeong, Yong Hoon Lee, Hyewon Seo, Seung Soo Yoo, Jaehee Lee, Seung Ick Cha, Chang Ho Kim, Yangki Seok, Sukki Cho, Sanghoon Jheon, Jae Yong ParkAbstractThis study was conducted to explore whether polymorphisms of glucose transporter 3 (GLUT3) gene affect the prognosis of patients with non-small...
Fri Apr 05, 2019 14:11
Publication date: Available online 3 April 2019Source: GeneAuthor(s): Bodhisattwa Banerjee, Debaprasad Koner, Rubaiya Hasan, Samir Bhattacharya, Nirmalendu SahaAbstractThe facultative air-breathing magur catfish (Clarias magur) frequently face different environmental challenges, such as hyper-ammonia, and desiccation stresses in their natural habitats. All these stresses lead to higher accumulation of body ammonia, thereby causing various harmful effects to the fish due to its toxicity. Nonetheless,...
Thu Apr 04, 2019 14:47
Publication date: Available online 3 April 2019Source: GeneAuthor(s): Yuhui Bu, Libo Shi, Dehai Yu, Zenghui Liang, Weidong LiAbstractEndocrine therapy is effective in the early stage of breast cancer treatment, and most tumor cells will gain the ability to proliferate under residual amounts of estrogen, which will cause the recurrence of the disease. The role of cell division cycle associated 8 (CDCA8) in Estradiol (E2)-stimulated breast cancer cells growth is investigated in this research. CDCA8...
Thu Apr 04, 2019 14:47
Genes, Vol. 10, Pages 281: Genetic Diversity and Population Structure Analysis of Dalbergia Odorifera Germplasm and Development of a Core Collection Using Microsatellite Markers Genes doi: 10.3390/genes10040281 Authors: Liu Zhang Liu Yang Jia Xu Dalbergia odorifera T. Chen (Fabaceae) is a woody tree species indigenous to Hainan Island in China. Due to its high medicinal and commercial value, this tree species has been planted over 3500 ha2 in southern China. There...
Sat Apr 06, 2019 03:00
Genes, Vol. 10, Pages 279: Clinical and Molecular Differences between 4-Year-Old Monozygous Male Twins Mosaic for Normal, Premutation and Fragile X Full Mutation Alleles Genes doi: 10.3390/genes10040279 Authors: Pandelache Baker Aliaga Arpone Forbes Stark Francis Godler : This study describes monozygotic (MZ) male twins with fragile X syndrome (FXS), mosaic for normal size (NS: <44 CGGs), premutation (PM: 55–199 CGG) and full mutation (FM...
Fri Apr 05, 2019 03:00
Genes, Vol. 10, Pages 280: The Primary Antisense Transcriptome of Halobacterium salinarum NRC-1 Genes doi: 10.3390/genes10040280 Authors: de Almeida Vêncio Lorenzetti Caten Gomes-Filho Koide Antisense RNAs (asRNAs) are present in diverse organisms and play important roles in gene regulation. In this work, we mapped the primary antisense transcriptome in the halophilic archaeon Halobacterium salinarum NRC-1. By reanalyzing publicly available data, we mapped antisense...
Fri Apr 05, 2019 03:00
Genes, Vol. 10, Pages 278: Correction of NR2E3 Associated Enhanced S-cone Syndrome Patient-specific iPSCs using CRISPR-Cas9 Genes doi: 10.3390/genes10040278 Authors: Laura R. Bohrer Luke A. Wiley Erin R. Burnight Jessica A. Cooke Joseph C. Giacalone Kristin R. Anfinson Jeaneen L. Andorf Robert F. Mullins Edwin M. Stone Budd A. Tucker Enhanced S-cone syndrome (ESCS) is caused by recessive mutations in the photoreceptor cell transcription factor NR2E3. Loss of...
Fri Apr 05, 2019 03:00
Genes, Vol. 10, Pages 274: Perinatal Lead (Pb) Exposure and Cortical Neuron-Specific DNA Methylation in Male Mice Genes doi: 10.3390/genes10040274 Authors: Dou Farooqui Faulk Barks Jones Dolinoy Bakulski : Lead (Pb) exposure is associated with a wide range of neurological deficits. Environmental exposures may impact epigenetic changes, such as DNA methylation, and can affect neurodevelopmental outcomes over the life-course. Mating mice were obtained from a genetically...
Thu Apr 04, 2019 03:00
Genes, Vol. 10, Pages 276: FARMAPRICE: A Pharmacogenetic Clinical Decision Support System for Precise and Cost-Effective Therapy Genes doi: 10.3390/genes10040276 Authors: Roncato Dal Cin Mezzalira Comello De Mattia Bignucolo Giollo D'Errico Gulotta Emili Carbone Guardascione Foltran Toffoli Cecchin Pharmacogenetic (PGx) guidelines for the precise dosing and selection of drugs remain poorly implemented in current clinical practice....
Thu Apr 04, 2019 03:00
Genes, Vol. 10, Pages 277: Azathioprine Biotransformation in Young Patients with Inflammatory Bowel Disease: Contribution of Glutathione-S Transferase M1 and A1 Variants Genes doi: 10.3390/genes10040277 Authors: Lucafò Stocco Martelossi Favretto Franca Malusà Lora Bramuzzo Naviglio Cecchin Toffoli Ventura Decorti The contribution of candidate genetic variants involved in azathioprine biotransformation on azathioprine efficacy and pharmacokinetics...
Thu Apr 04, 2019 03:00
Genes, Vol. 10, Pages 275: Uncovering Missing Heritability in Rare Diseases Genes doi: 10.3390/genes10040275 Authors: Maroilley Tarailo-Graovac The problem of ‘missing heritability’ affects both common and rare diseases hindering: discovery, diagnosis, and patient care. The ‘missing heritability’ concept has been mainly associated with common and complex diseases where promising modern technological advances, like genome-wide association studies...
Thu Apr 04, 2019 03:00
AbstractRegulation of gene expression is an important mechanism through which genetic variation can affect complex traits. A substantial portion of gene expression variation can be explained by both local (cis) and distal (trans) genetic variation. Much progress has been made in uncovering cis‐acting expression quantitative trait loci (cis‐eQTL), but trans‐eQTL have been more difficult to identify and replicate. Here we take advantage of our ability to predict the cis component of gene...
Thu Apr 04, 2019 19:04
Pathogens, Vol. 8, Pages 47: ApiAP2 Transcription Factors in Apicomplexan Parasites Pathogens doi: 10.3390/pathogens8020047 Authors: Myriam D. Jeninga Jennifer E. Quinn Michaela Petter Apicomplexan parasites are protozoan organisms that are characterised by complex life cycles and they include medically important species, such as the malaria parasite Plasmodium and the causative agents of toxoplasmosis (Toxoplasma gondii) and cryptosporidiosis (Cryptosporidium spp.). Apicomplexan...
Sun Apr 07, 2019 03:00
Pathogens, Vol. 8, Pages 46: Genetic Diversity of Salmonella Derby from the Poultry Sector in Europe
Pathogens, Vol. 8, Pages 46: Genetic Diversity of Salmonella Derby from the Poultry Sector in Europe Pathogens doi: 10.3390/pathogens8020046 Authors: Sévellec Felten Radomski Granier Le Hello Petrovska Mistou Cadel-Six Salmonella Derby (S. Derby) is emerging in Europe as a predominant serovar in fattening turkey flocks. This serovar was recorded as being predominant in the turkey sector in 2014 in the United Kingdom (UK). Only two years later, in 2016, it...
Thu Apr 04, 2019 03:00
Pathogens, Vol. 8, Pages 45: The Hidden Cost of Modern Medical Interventions: How Medical Advances Have Shaped the Prevalence of Human Fungal Disease Pathogens doi: 10.3390/pathogens8020045 Authors: Callum Clark Rebecca A. Drummond Life expectancy in the West is the highest it has ever been, due to the introduction of better hygiene practices and sophisticated medical interventions for cancer, autoimmunity and infectious disease. With these modern advances, a rise in the prevalence...
Thu Apr 04, 2019 03:00
by Andy Dahl, Na Cai, Arthur Ko, Markku Laakso, Päivi Pajukanta, Jonathan Flint, Noah Zaitlen Recent and classical work has revealed biologically and medically significant subtypes in complex diseases and traits. However, relevant subtypes are often unknown, unmeasured, or actively debated, making automated statistical approaches to subtype definition valuable. We propose reverse GWAS (RGWAS) to identify and validate subtypes using genetics and multiple traits: while GWAS seeks the genetic basis...
Fri Apr 05, 2019 20:39
by Clare C. So, Alberto Martin Class switch recombination (CSR) requires activation-induced cytidine deaminase (AID) to trigger DNA double strand breaks (DSBs) at the immunoglobulin heavy chain (IGH) in B cells. Joining of AID-dependent DSBs within IGH facilitate CSR and effective humoral immunity, but ligation to DSBs in non-IGH chromosomes leads to chromosomal translocations. Thus, the mechanism by which AID-dependent DSBs are repaired requires careful examination. The random activity of AID...
Thu Apr 04, 2019 20:57
by René Richter, Atsuko Kinoshita, Coral Vincent, Rafael Martinez-Gallegos, He Gao, Annabel D. van Driel, Youbong Hyun, Julieta L. Mateos, George Coupland Integration of environmental and endogenous cues at plant shoot meristems determines the timing of flowering and reproductive development. The MADS box transcription factor FLOWERING LOCUS C (FLC) of Arabidopsis thaliana is an important repressor of floral transition, which blocks flowering until plants are exposed to winter cold. However,...
Thu Apr 04, 2019 20:57
by Zhixiu Li, Servet Akar, Handan Yarkan, Sau Kuen Lee, Pınar Çetin, Gerçek Can, Gökce Kenar, Fernur Çapa, Omer Nuri Pamuk, Yavuz Pehlivan, Katie Cremin, Erika De Guzman, Jessica Harris, Lawrie Wheeler, Ahmadreza Jamshidi, Mahdi Vojdanian, Elham Farhadi, Nooshin Ahmadzadeh, Zeynep Yüce, Ediz Dalkılıç, Dilek Solmaz, Berrin Akın, Salim Dönmez, İsmail Sarı, Paul J. Leo, Tony J. Kenna, Fatos Önen, Mahdi Mahmoudi, Matthew A. Brown, Nurullah Akkoc Ankylosing spondylitis (AS) is a highly heritable...
Thu Apr 04, 2019 20:57
by Nick Brouwers, Arthur R. Gorter de Vries, Marcel van den Broek, Susan M. Weening, Tom D. Elink Schuurman, Niels G. A. Kuijpers, Jack T. Pronk, Jean-Marc G. Daran Saccharomyces eubayanus is the non-S. cerevisiae parent of the lager-brewing hybrid S. pastorianus. In contrast to most S. cerevisiae and Frohberg-type S. pastorianus strains, S. eubayanus cannot utilize the α-tri-glucoside maltotriose, a major carbohydrate in brewer's wort. In Saccharomyces yeasts, utilization of maltotriose is...
Thu Apr 04, 2019 20:42
by Julie D. White, David A. Puts
Thu Apr 04, 2019 20:42
by Bowen Hu, Ning Shen, James J. Li, Hyunseung Kang, Jinkuk Hong, Jason Fletcher, Jan Greenberg, Marsha R. Mailick, Qiongshi Lu Facial attractiveness is a complex human trait of great interest in both academia and industry. Literature on sociological and phenotypic factors associated with facial attractiveness is rich, but its genetic basis is poorly understood. In this paper, we conducted a genome-wide association study to discover genetic variants associated with facial attractiveness using...
Thu Apr 04, 2019 20:42
by EmilyClare P. Baker, Chris Todd Hittinger At the molecular level, the evolution of new traits can be broadly divided between changes in gene expression and changes in protein-coding sequence. For proteins, the evolution of novel functions is generally thought to proceed through sequential point mutations or recombination of whole functional units. In Saccharomyces, the uptake of the sugar maltotriose into the cell is the primary limiting factor in its utilization, but maltotriose transporters...
Thu Apr 04, 2019 20:42
by Shu-Jung Chang, Sheng Chih Jin, Xuyao Jiao, Jorge E. Galán Typhoid toxin is a virulence factor for Salmonella Typhi and Paratyphi, the cause of typhoid fever in humans. This toxin has a unique architecture in that its pentameric B subunit, made of PltB, is linked to two enzymatic A subunits, the ADP ribosyl transferase PltA and the deoxyribonuclease CdtB. Typhoid toxin is uniquely adapted to humans, recognizing surface glycoprotein sialoglycans terminated in acetyl neuraminic acid, which...
Fri Apr 05, 2019 20:39
by Diego S. Ferrero, Victor M. Ruiz-Arroyo, Nicolas Soler, Isabel Usón, Alba Guarné, Núria Verdaguer Zika virus (ZIKV), a member of the Flaviviridae family, has emerged as a major public health threat, since ZIKV infection has been connected to microcephaly and other neurological disorders. Flavivirus genome replication is driven by NS5, an RNA-dependent RNA polymerase (RdRP) that also contains a N-terminal methyltransferase domain essential for viral mRNA capping. Given its crucial roles, ZIKV...
Fri Apr 05, 2019 20:39
by K. Lane Warmbrod, Edward I. Patterson, Tiffany F. Kautz, Adam Stanton, Dedeke Rockx-Brouwer, Birte K. Kalveram, Kamil Khanipov, Saravanan Thangamani, Yuriy Fofanov, Naomi L. Forrester The presence of bottlenecks in the transmission cycle of many RNA viruses leads to a severe reduction of number of virus particles and this occurs multiple times throughout the viral transmission cycle. Viral replication is then necessary for regeneration of a diverse mutant swarm. It is now understood that...
Thu Apr 04, 2019 20:57
by Nicholas Raffa, Nancy P. Keller
Thu Apr 04, 2019 20:42
Subversion of natural killer cell responses by a cytomegalovirus-encoded soluble CD48 decoy receptor
by Pablo Martínez-Vicente, Domènec Farré, Carolina Sánchez, Antonio Alcamí, Pablo Engel, Ana Angulo Throughout evolution, cytomegaloviruses (CMVs) have been capturing genes from their hosts, employing the derived proteins to evade host immune defenses. We have recently reported the presence of a number of CD48 homologs (vCD48s) encoded by different pathogenic viruses, including several CMVs. However, their properties and biological relevance remain as yet unexplored. CD48, a cosignaling molecule...
Thu Apr 04, 2019 20:42
by Sam X. Li, Sharon Sen, Jennifer M. Schneider, Ka-Na Xiong, Nichole M. Nusbacher, Nancy Moreno-Huizar, Michael Shaffer, Abigail J. S. Armstrong, Erin Severs, Kristine Kuhn, Charles P. Neff, Martin McCarter, Thomas Campbell, Catherine A. Lozupone, Brent E. Palmer Men who have sex with men (MSM) have differences in immune activation and gut microbiome composition compared with men who have sex with women (MSW), even in the absence of HIV infection. Gut microbiome differences associated with...
Thu Apr 04, 2019 20:42
by Carmen Melatti, Manuela Pieperhoff, Leandro Lemgruber, Ehmke Pohl, Lilach Sheiner, Markus Meissner The single mitochondrion of apicomplexan protozoa is thought to be critical for all stages of the life cycle, and is a validated drug target against these important human and veterinary parasites. In contrast to other eukaryotes, replication of the mitochondrion is tightly linked to the cell cycle. A key step in mitochondrial segregation is the fission event, which in many eukaryotes occurs...
Thu Apr 04, 2019 20:42
PHOENIX, Ariz. — April 5, 2019 — Hepatocellular carcinoma (HCC) is a long medical name for the most common form of liver cancer, a malignancy whose incidence has nearly doubled over the past decade, making it the fastest growing type of cancer in the U.S., and the third-leading cause of cancer-related death worldwide. In an article published today in the scientific journal Cancers , a pair of researchers at the Translational Genomics Research Institute (TGen) , an affiliate of City of Hope , provide...
Fri Apr 05, 2019 16:56
PHOENIX, Ariz. — April 5, 2019 — Hepatocellular carcinoma (HCC) is a long medical name for the most common form of liver cancer, a malignancy whose incidence has nearly doubled over the past decade, making it the fastest growing type of cancer in the U.S., and the third-leading cause of cancer-related death worldwide. In an article published today in the scientific journal Cancers , a pair of researchers at the Translational Genomics Research Institute (TGen) , an affiliate of City of Hope , provide...
Fri Apr 05, 2019 16:56
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