Scholar : Ειδοποίηση Μελετητή - [ ΑΠΟΚΑ

Ειδοποίηση Μελετητή:[ ΑΠΟΚΑΤΑΣΤΑΣΗ ]

Αποτελεσματικότητα εφαρμογής προσθετικών μελών και ο ρόλος της φυσικοθεραπείας

Κ Αχριάνη, Ν Κοτσαρίνη, Μ Μουλοπούλου - 2017

... τέθηκε από την ερευνητική ομάδα, ήταν η διερεύνηση των επιρροών της χρήσης προσθετικών
μελών στην καθημερινότητα των ακρωτηριασμένων ατόμων, καθώς και ο ρόλος της
φυσικοθεραπείας, ως καταλυτικός παράγοντας για μια επιτυχημένη αποκατάσταση και επανένταξη ...

Επίδραση του προγράμματος της πνευμονικής αποκατάστασης στον περιορισμό εκπνευστικής ροής κατά τη διάρκεια της άσκησης και στη δυναμική υπερδιάταση σε …

Ε Θεοδωρακοπούλου - 2017

... Πριν την αποκατάσταση 16 ασθενείς παρουσίασαν το φαινόμενο του περιορισμού της εκπνευστικής
ροής στην ηρεμία ή/και στην άσκηση. ... Πριν την αποκατάσταση 16 ασθενείς παρουσίασαν το
φαινόμενο του περιορισμού της εκπνευστικής ροής στην ηρεμία ή/και στην άσκηση. ...

[PDF] Λογοτεχνικά αλφαβητάρια: κριτική προσέγγιση και διδακτική εφαρμογή

ΑΝ Ακριτόπουλος - Παιδαγωγική επιθεώρηση, 2017

... Ένα καλύτερο ή έτοιμο παράδειγμα, όσον αφορά στους ρόλους, αποτελεί το αλφαβητάριο της
Σοφίας Χατζηνικολάου, Στη χώρα των Γραμμάτων, γραμμένο με τη μορφή θεατρικού παραμυθιού,
αλλά αυτό στοχεύει στην αποκατάσταση των «γραμμάτων» κυριολεκτικά και ...

[PDF] Η μελέτη της ικανοποίησης των millennials από οδοντιατρικές υπηρεσίες με χρήση πολυκριτήριας ανάλυσης

Σ Βλασταράκος - 2017

... Υγεία- Στοματική Υγεία Σύμφωνα με το ν.3418/2005 του Κώδικα Ιατρικής Δεοντολογίας,
η Ιατρική έχει ως σκοπό με τη χρήση οποιασδήποτε επιστημονικής μεθόδου την πρόληψη,
διάγνωση, θεραπεία και αποκατάσταση της υγείας του ανθρώπου. ...

Ο ρόλος της όρασης σε παιδιά με κινητικές δυσλειτουργίες-διαταραχές

Σ Μαρκετάκη, Β Σπαρτινού - 2017

Ιδρυματικό Καταθετήριο Τ.Ε.Ι. Δυτικής Ελλάδας Ο ρόλος της όρασης σε
παιδιά με κινητικές δυσλειτουργίες-διαταραχές. Σύνδεση. ...

[PDF] Η κατανομή των πόρων σε επίπεδο πρωτοβάθμιας φροντίδας υγείας «H περίπτωση του Ελληνικού Ερυθρού Σταυρού»

Α Ζάγγα - 2017

Page 1. ΑΝΩΤΑΤΟ ΤΕΧΝΟΛΟΓΙΚΟ ΕΚΠΑΙΔΕΥΤΙΚΟ ΙΔΡΥΜΑ ΠΕΙΡΑΙΑ ΤΜΗΜΑ
ΔΙΟΙΚΗΣΗ ΕΠΙΧΕΙΡΗΣΕΩΝ ΕΥΡΩΠΑΙΚΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΤΗΣ ΚΥΠΡΟΥ ΤΜΗΜΑ
ΕΠΙΣΤΗΜΩΝ ΥΓΕΙΑΣ ΜΕΤΑΠΤΥΧΙΑΚΗ ΔΙΠΛΩΜΑΤΙΚΗ ΕΡΓΑΣΙΑ ...

[PDF] Μελέτη κόστους-χρησιμότητας σε ασθενείς που έχουν υποβληθεί σε τοποθέτηση οδοντικών εμφυτευμάτων

Ε Παππά - 2017

... 117 Πίνακας 6.14 Αντιπροσωπευτικών ποσοστών (του συνόλου του δείγματος
)των ερωτηθέντων κατανεμημένα ανά φύλο και προσθετική αποκατάσταση .....
118 ... ανά φύλο και προσθετική αποκατάσταση ..... 119 Page 12. 12 ...

[PDF] Διοίκηση και δομή δημόσιων και ιδιωτικών φορέων υγείας στην Ελλάδα: Ένα μοντέλο βελτίωσης των παρεχόμενων υπηρεσιών.

Ι Κρίνα - 2017

... και ο ορισμός που έχει δοθεί από τον παγκόσμιο οργανισμό υγείας ορίζοντας ως σύστημα υγείας
εκείνο το σύστημα που περιέχει όλες τις απαραίτητες πράξεις οι οποίες επιτυγχάνουν την πρόληψη,
την αποκατάσταση και την διατήρηση της υγείας των πολιτών (WHO,2000). 15 ...

[PDF] Η Επίδραση της καινοτομίας και των επενδύσεων σε τεχνολογίες στην ανταγωνιστικότητα των επιχειρήσεων μέσω των ευρωπαϊκών προγραμμάτων υποστήριξης της …

Σ Μηλιώνη - 2017

Page 1. 1 ΑΝΩΤΑΤΟ ΕΚΠΑΙΔΕΥΤΙΚΟ ΙΔΡΥΜΑ ΤΕΧΝΟΛΟΓΙΚΟΥ ΤΟΜΕΑ Τ.Ε.Ι. ΠΕΙΡΑΙΑ ΣΧΟΛΗ
ΔΙΟΙΚΗΣΗΣ & ΟΙΚΟΝΟΜΙΑΣ ΤΜΗΜΑ ΔΙΟΙΚΗΣΗΣ ΕΠΙΧΕΙΡΗΣΕΩΝ ΠΤΥΧΙΑΚΗ ΕΡΓΑΣΙΑ «Η
Επίδραση της Καινοτομίας και των Επενδύσεων σε Τεχνολογίες στην ...

[PDF] Τα κοινωνικά δικαιώματα σε κρίση. Η περίπτωση της υγείας στην Ελλάδα

Α Γκάτσου - 2017

Page 1. Μεταπτυχιακή Διπλωματική Εργασία: ΘΕΜΑ: Τα Κοινωνικά Δικαιώματα σε κρίση. Η
περίπτωση της Υγείας στην Ελλάδα. Επιμέλεια: Γκάτσου Αικατερίνη Επιβλέπων Καθηγητής:
Οικονόμου Χαράλαμπος Αθήνα, Φεβρουάριος, 2017 Page 2. Τα Κοινωνικά Δικαιώματα σε κρίση. ...

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Scholar : Ειδοποίηση Μελετητή - [ intitle:Bi

Ειδοποίηση Μελετητή:[ intitle:Bioprinting ]

Gelatin/alginate hydrogel scaffolds prepared by 3D bioprinting promotes cell adhesion and proliferation of human dental pulp cells in vitro

HY Yu, DD Ma, BL Wu - Nan fang yi ke da xue xue bao= Journal of Southern …, 2017

OBJECTIVE: To evaluate the cytotoxicity of gelatin/alginate hydrogel scaffolds prepared by
3D bioprinting in human dental pulp cells (HDPCs) and compare the cell adhesion and
proliferation of the cells seeded in the biomaterial using two different methods. METHODS:

Natural polysaccharide-based self-healing hydrogels for 3-D bioprinting

김상우， 이근용 - 한국고분자학회 학술대회 연구논문 초록집, 2017

... Natural polysaccharide-based self-healing hydrogels for 3-D bioprinting. 김상우, 이근용.
한국고분자학회 2017년도 춘계학술대회 연구논문 초록집 PROCEEDINGS 제42권 제1호,
2017.4, 80-80 (1 page) 인용정보 복사. 구매하기 1,000원 해당 자료는 3page 이하로 구성되어

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Scholar : Ειδοποίηση Μελετητή - [ ογκοι

Ειδοποίηση Μελετητή:[ ογκοι κεφαλης τραχηλου ]

[PDF] Η κατανομή των πόρων σε επίπεδο πρωτοβάθμιας φροντίδας υγείας «H περίπτωση του Ελληνικού Ερυθρού Σταυρού»

Α Ζάγγα - 2017

Page 1. ΑΝΩΤΑΤΟ ΤΕΧΝΟΛΟΓΙΚΟ ΕΚΠΑΙΔΕΥΤΙΚΟ ΙΔΡΥΜΑ ΠΕΙΡΑΙΑ ΤΜΗΜΑ
ΔΙΟΙΚΗΣΗ ΕΠΙΧΕΙΡΗΣΕΩΝ ΕΥΡΩΠΑΙΚΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΤΗΣ ΚΥΠΡΟΥ ΤΜΗΜΑ
ΕΠΙΣΤΗΜΩΝ ΥΓΕΙΑΣ ΜΕΤΑΠΤΥΧΙΑΚΗ ΔΙΠΛΩΜΑΤΙΚΗ ΕΡΓΑΣΙΑ ...

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Scholar : Ειδοποίηση Μελετητή - [ ΓΛΩΣΣ

Ειδοποίηση Μελετητή:[ ΓΛΩΣΣΙΤΙΣ ]

[PDF] AIDS related complex-A case report

K Saurabh, SA Sami, Q Sabiya, A Anant, A Naeem… - IJAR, 2017

... shape is oval. Base is erythematous. Fig 2: Erythematous Candidiasis Fig 3: Aphtuous Ulcers
Fig 4: Median Rhomboid Glossitis Median rhomboid glossitis present. Aphthous ulcers were
also seen. Palpation - Inspectory findings were confirmed, ulcers were non tender. ...

[PDF] Inherited Paediatric Motor Neuron Disorders: Beyond Spinal Muscular Atrophy

HL Teoh, K Carey, H Sampaio, D Mowat, T Roscioli… - Neural Plasticity, 2017

... 92]. Additional multisystem features include achalasia (Figure 3(c)), gastroparesis,
glossitis, adrenal insufficiency, hyperpigmentation, palmar-plantar hyperkeratosis,
short stature, osteoporosis, and microcephaly. Neurological ...

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Scholar : Ειδοποίηση Μελετητή - [ ΑΚΟΗ ]

Ειδοποίηση Μελετητή:[ ΑΚΟΗ ]

[PDF] Μελέτη κόστους-χρησιμότητας σε ασθενείς που έχουν υποβληθεί σε τοποθέτηση οδοντικών εμφυτευμάτων

Ε Παππά - 2017

Page 1. ΔΙΠΛΩΜΑΤΙΚΗ ΕΡΓΑΣΙΑ «Μελέτη κόστους-χρησιμότητας σε ασθενείς που έχουν
υποβληθεί σε τοποθέτηση οδοντικών εμφυτευμάτων» Επιμέλεια: Ελιόνα Παππά Α.Μ: ΔΜΥ-24
Επιβλέπων Καθηγητής: Δρ. Αθανάσιος Βοζίκης Αθήνα, Φεβρουάριος 2017 Page 2. 2 Page 3. ...

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Scholar : Ειδοποίηση Μελετητή - [ ΑΠΝΟΙ

Ειδοποίηση Μελετητή:[ ΑΠΝΟΙΑ ]

Αντιμετώπιση βρέφους με αναπνευστική δυσχέρεια. Ο ρόλος του νοσηλευτή

Ο Αθανασοπούλου - 2017

... βρογχιολίτιδα. Η κλινική εικόνα του βρέφους με αναπνευστική δυσχέρεια περιλαμβάνει
ταχύπνοια, διακοπή της αναπνοής, κεντρική κυάνωση, αναπέταση ρινικών χοανών,
άπνοια, συριγμό, γογγυσμό, κροταλισμό, τρίζοντες και ρόγχους. ...

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Scholar : Ειδοποίηση Μελετητή - [ Εμφυτ

Ειδοποίηση Μελετητή:[ Εμφυτευματα ]

[PDF] Μελέτη κόστους-χρησιμότητας σε ασθενείς που έχουν υποβληθεί σε τοποθέτηση οδοντικών εμφυτευμάτων

Ε Παππά - 2017

... 62 3.2.1 Συμβατικές Προσθετικές Αποκαταστάσεις ..... 65 3.2.2 Οδοντικά Εμφυτεύματα ..... ...
124 6.4 Ερωτήσεις σχετικά με τα οδοντικά εμφυτεύματα..... ...

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Scholar : Ειδοποίηση Μελετητή - [ ΜΑΣΤΟ

Ειδοποίηση Μελετητή:[ ΜΑΣΤΟΕΙΔΙΤΙΣ ]

[HTML] Bezold's abscess in a diabetic patient without significant clinical symptoms

K Katayama, H Gomi, T Shirokawa, H Akizuki… - IDCases, 2017

... Bezold's abscess is a deep neck abscess arising from mastoiditis. • Immunosuppressive state
obscures the symptoms of abscess. • ... ・ Bezold’s abscess is a deep neck abscess arising
from mastoiditis. ・ Immunosuppressive state obscures the symptoms of abscess. ...

Comparaison des modalités de traitements antibiotiques post-opératoires des mastoïdites aiguës sans complication intracrânienne chez l'enfant

N Rouillard-Bazinet - 2017

... Acute mastoiditis is one of the most common complication of acute otitis media in children under
two years old. ... Our objective was to compare the oral and intravenous post-operative treatments
of pediatric acute mastoiditis without intracranial complication. ...

Hearing loss in patients with extracranial complications of chronic otitis media.

T Przewoźny, J Kuczkowski - Otolaryngologia polska= The Polish otolaryngology, 2017

... As regards the severity of hearing impairment in pure tone average the prevalence of
complications was as follows: labyrinthitis (77.8±33.6 dBHL), facial palsy (57.1±14.3 dBHL),
perilymphatic fistula (53.9±19.9 dBHL) and mastoiditis (42.2±9.5 dBHL) (p=0.023). ...

[PDF] Die Funktion von intrazerebralen Makrophagen beim Staphylococcus aureus-induzierten Hirnabszess im Kontext der IL-4R-abhängigen Aktivierung

L Zobel - 2017

... des Patienten. Ursache ist in etwa 50% der Fälle eine Absiedlung von Bakterien eines nahe
gelegenen Entzündungsherdes wie beispielsweise einer Otitis media, Sinusitis, Mastoiditis oder
einer Entzündung der Zähne (14-17). Hierbei entstehen meist solitäre, ...

Diagnóstico microbiológico de las infecciones relacionadas con la formación de biopelículas

MD Macià, JL del Pozo, M Díez-Aguilar, J Guinea - Enfermedades Infecciosas y …, 2017

... La incidencia de infección asociada a implantes cocleares es baja, situándose entre el
1,6 y 10%. Lo más frecuente es que se afecte la herida quirúrgica, seguida de otitis media
y las complicaciones derivadas como la mastoiditis o la meningitis. ...

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Scholar : Ειδοποίηση Μελετητή - [ Χειρο

Ειδοποίηση Μελετητή:[ Χειρουργική Κεφαλής και Τραχήλου ]

[PDF] Η κατανομή των πόρων σε επίπεδο πρωτοβάθμιας φροντίδας υγείας «H περίπτωση του Ελληνικού Ερυθρού Σταυρού»

Α Ζάγγα - 2017

Page 1. ΑΝΩΤΑΤΟ ΤΕΧΝΟΛΟΓΙΚΟ ΕΚΠΑΙΔΕΥΤΙΚΟ ΙΔΡΥΜΑ ΠΕΙΡΑΙΑ ΤΜΗΜΑ
ΔΙΟΙΚΗΣΗ ΕΠΙΧΕΙΡΗΣΕΩΝ ΕΥΡΩΠΑΙΚΟ ΠΑΝΕΠΙΣΤΗΜΙΟ ΤΗΣ ΚΥΠΡΟΥ ΤΜΗΜΑ
ΕΠΙΣΤΗΜΩΝ ΥΓΕΙΑΣ ΜΕΤΑΠΤΥΧΙΑΚΗ ΔΙΠΛΩΜΑΤΙΚΗ ΕΡΓΑΣΙΑ ...

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Psychometric Properties of Two Participation Measures in Veterans with Mild Traumatic Brain Injury

Publication date: Available online 3 June 2017
Source:Archives of Physical Medicine and Rehabilitation
Author(s): Pey-Shan Wen, J. Kay Waid-Ebbs, David P. Graham, Drew A. Helmer
ObjectiveTo compare the psychometric properties of two commonly used participation measures: the Community Reintegration of Service Members (CRIS) and the Participation Assessment with Recombined Tools-Objective (PART-O) in Veterans with mild traumatic brain injury (mTBI).DesignThe data were collected from two cross-sectional observation studies conducted in two Veterans Affairs medical centers.SettingQuestionnaires were completed in-person or by mail.ParticipantsVeterans with mild TBI were recruited from the Michael E. DeBakey Veterans Affairs Medical Center in Houston (N=94) and the Malcom Randall North Florida/South Georgia Veterans Health System (N=107).InterventionsNot applicable.Main Outcome Measures:CRIS and PART-O.ResultsWe conducted Rasch analysis on the PART-O and on three subscales of the CRIS (Extent of Participation, Perceived Limitation, and Satisfaction). For PART-O, results showed PART-O has questionable unidimensionality. For both instruments, some rating categories were under used and rating scales did not advance accordingly. Compared with PART-O, the CRIS was able to distinguish more categories of a person's ability (>5 vs 2 by PART-O ) and had better internal consistency as indicated by higher Cronbach's Alpha (0.96-0.98vs 0.65 for PART-O).ConclusionsTo capture participation unique to Veterans with mTBI, CRIS has greater potential to detect a change in participation and is therefore recommended over PART-O. Rating scales of both instruments, however, need further refinement. We suggest future studies examine collapsed rating categories and use qualitative methods to redefine categories.



http://ift.tt/2rPy9Jj

Decreased Anticipatory Postural Adjustments During Gait Initiation Acutely Post-Concussion

Publication date: Available online 3 June 2017
Source:Archives of Physical Medicine and Rehabilitation
Author(s): Thomas A. Buckley, Jessie R. Oldham, Barry A. Munkasy, Kelsey E. Evans
ObjectiveThe purpose of this study was to investigate anticipatory postural adjustments (APA) during the transitional movement task of gait initiation (GI) in individuals acutely following a concussion.DesignCohort Study.SettingUniversity Research Center.ParticipantsA population based sample of 84 participants divided into two equal groups of acutely post-concussion (CONC) and healthy student athletes.InterventionParticipants were tested on two occasions – a pre-injury baseline test and then the CONC group was retested acutely post-concussion and the control group again at a similar time. All participants completed 5 trials of GI on 4 forceplates.Main Outcome MeasuresThe dependent variables were the displacement and velocity of the center of pressure (COP) during the APA phase and initial step kinematics. Comparisons were made with a 2 (Group) x 2 (Time) repeated measures ANOVA.ResultsThere was a significant interaction for COP posterior displacement (P<0.001) and lateral displacement (P<0.001). Posteriorly, post-hoc testing identified a significant reduction in CONC (PRE: 5.7 + 1.6 cm and POST: 2.6 + 2.1 cm, P<0.001), but no difference in Control (PRE: 4.0 + 1.6 cm and POST: 4.0 + 2.5 cm, P=0.921). Laterally, post-hoc testing identified a significant reduction in CONC (PRE: 5.8 + 2.1 cm and POST: 3.8 + 1.8 cm, P<0.001), but no difference in Control (PRE: 5.0 + 2.5 cm and POST: 5.2 + 2.4 cm, P=0.485).ConclusionsThe results of this study suggest difficulty in the planning and execution of GI acutely post-concussion and posterior APA displacement and velocity are highly effective measures of impaired postural control. Finally, the APA phase is linked to the supplementary motor area which suggests a supraspinal contribution to post-concussion impaired postural control.



http://ift.tt/2soL2Hp

Functional Status is Associated with 30-day Potentially Preventable Hospital Readmissions following Inpatient Rehabilitation among Aged Medicare Fee-for-Service Beneficiaries

Publication date: Available online 3 June 2017
Source:Archives of Physical Medicine and Rehabilitation
Author(s): Addie Middleton, James E. Graham, Kenneth J. Ottenbacher
ObjectiveTo determine the association between patients' functional status at discharge from inpatient rehabilitation and 30-day potentially preventable hospital readmissions. A secondary objective was to examine the conditions resulting in these potentially preventable readmissions.DesignRetrospective cohort study.SettingInpatient rehabilitation facilities submitting claims to Medicare.ParticipantsNational cohort of 371,846 inpatient rehabilitation discharges among aged Medicare fee-for-service beneficiaries in 2013-2014. The average age was 79.1 (SD, 7.6) years. A majority were female (59.7%) and non-Hispanic white (84.5%).InterventionsNot applicable.Main Outcome Measures1) Observed rates and adjusted odds of 30-day potentially preventable hospital readmissions following inpatient rehabilitation and 2) primary diagnoses for readmissions.ResultsThe overall rate of any 30-day hospital readmission following inpatient rehabilitation was 12.4% (N=46,265) and the overall rate of potentially preventable readmissions was 5.0% (N=18,477). Functional independence was associated with lower observed rates and adjusted odds ratios for potentially preventable readmissions. Observed rates (95% CI) for the highest vs. lowest quartiles within each functional domain were as follows: self-care: 3.4% (3.3-3.5) vs 6.9% (6.7-7.1); mobility: 3.3% (3.2-3.4) vs 7.2% (7.0-7.4); cognition 3.5% (3.4-3.6) vs 6.2% (6.0-6.4). Similarly, adjusted odds ratios were as follows: self-care: 0.70 (0.67-0.74); mobility: 0.64 (0.61-0.68); cognition: 0.84 (0.80-0.89). Infection-related conditions (44.1%) were the most common readmission diagnoses followed by inadequate management of chronic conditions (31.2%) and inadequate management of other unplanned events (24.7%).ConclusionsFunctional status at discharge from inpatient rehabilitation was associated with 30-day potentially preventable readmissions in our sample of aged Medicare beneficiaries. This information may help identify at-risk patients. Future research is needed to determine whether follow-up programs focused on improving functional independence will reduce readmission rates.



http://ift.tt/2rPG8Gn

Falls are Associated with Lower Self-reported Functional Status in Patients after Stroke

Publication date: Available online 3 June 2017
Source:Archives of Physical Medicine and Rehabilitation
Author(s): Eline van der Kooi, Sven Kersten Schiemanck, Frans Nollet, Gert Kwakkel, Jan-Willem Meijer, Ingrid Gerrie Lambert van de Port
ObjectiveTo evaluate the association between falls and functional status after stroke.DesignSecondary analysis of data from the randomised, controlled FIT-Stroke trial. Outcomes were measured at the time of discharge from inpatient rehabilitation (T0) and after 12 weeks (T1). Between T0 and T1, all patients attended an outpatient rehabilitation program that included the FIT-Stroke intervention.SettingNine Dutch centres for rehabilitation medicine.ParticipantsOutpatients after stroke with mild cognitive impairments (Mini-Mental State Examination [MMSE] ≥ 24), discharged home after inpatient rehabilitation and able to walk 10 meters independently.InterventionsNot applicable.Main Outcome MeasuresThe primary outcome was the change in Stroke Impact Scale (SIS)-16 score. The independent variable was one or more falls after stroke. The outcome was corrected for type of outpatient rehabilitation (group allocation), severity of hemiplegia (Motricity Index; MI), and cognition (MMSE) at baseline using multiple regression analysis.ResultsThe study included 250 patients after stroke. Complete data were available for 199 patients with a mean age of 58 years (SD 10), MMSE of 28.1 (SD 2), and MI of 130 (SD 43). Fifty-five patients (28%) reported falls during the 12 weeks after discharge from inpatient rehabilitation. Falls were significantly associated with less improvement in functional status as assessed with the SIS-16 (p=0.009).ConclusionAlmost 30% of this stroke population with minor cognitive deficits and moderate to high mobility scores reported falls during the 12 weeks of outpatient rehabilitation. Falls were negatively associated with self-reported functional status measured by the change in SIS-16 score. Therefore, it is important to identify patients with high risk of falls and implement strategies to reduce falls.



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A latent structural analysis of health outcomes among people living with spinal cord injury

Publication date: Available online 3 June 2017
Source:Archives of Physical Medicine and Rehabilitation
Author(s): Chao Li, Jillian M.R. Clark, James S. Krause
ObjectiveTo develop a latent structural model of health outcomes among people with spinal cord injury (SCI) that accounts for measurement of underlying factors and their association with demographic and injury-related exogenous variables.DesignCross-sectional studySettingsData were collected at a large specialty hospital and analyzed at a medical university in the Southeastern United StatesParticipants1871 participants with traumatic SCI of at least 1-year durationInterventionsN/AMain Outcome MeasuresExploratory factor analysis (EFA) was used to identify latent health outcome structures. Several key exogenous variables were also linked with the latent health outcome factors.ResultsSix latent health outcome factors were identified by the EFA with excellent model fit (root mean square error of approximation = 0.040). These latent factors included: (1) global health problems, (2) chronic disease, (3) acute treatments, (4) symptoms of SCI complications, (5) pressure ulcers, and (6) subsequent injuries. Sex, race/ethnicity, age, years since injury, and injury severity were all significantly associated with at least 1 latent health outcome factor, which indicates these latent health outcomes varied as a function of the exogenous variables.ConclusionThis study improved our understanding of the structure of health outcomes, and utilization of latent health outcome factors provides more stable and comprehensive composite scores than does utilization of a single observed health outcome indicator.



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Combination of active targeting, enzyme-triggered release and fluorescent dye into gold nanoclusters for endomicroscopy-guided photothermal/photodynamic therapy to pancreatic ductal adenocarcinoma

Publication date: September 2017
Source:Biomaterials, Volume 139
Author(s): Hui Li, Ping Wang, Yunxiang Deng, Meiying Zeng, Yan Tang, Wei-Hong Zhu, Yingsheng Cheng
Pancreatic ductal adenocarcinoma (PDAC) is one of the most devastating malignancies in patients, and there is an urgent need for an effective treatment method. Herein, we report a novel gold nanocluster-based platform for confocal laser endomicroscopy-guided photothermal therapy (PTT)/photodynamic therapy (PDT) for PDAC, which consists of four components: the PTT-carrier gold nanocluster, an active targeting ligand U11 peptide, a Cathepsin E (CTSE)-sensitive PDT therapy prodrug, and a CTSE-sensitive imaging agent (cyanine dye Cy5.5). Due to the strong coupling among cross-linked gold nanoparticles (AuNPs), the surface plasmon resonance peak of nanoclusters shifts to the near-infrared (NIR) region, thus making the nanoclusters useful in the effective PTT therapy. In the system, the labeling of nanoclusters with U11 peptide can distinctly increase their affinity and accelerate their uptake by pancreatic cancer cells. Cell apoptosis staining demonstrates that, upon incorporation of the uPAR-targeted unit, the antitumor efficacy of CTSE-sensitive nanocluster AuS-U11 is significantly enhanced with respect to that of the non-targeted nanocluster AuS-PEG and the insensitive nanocluster AuC-PEG. In vivo and ex vivo optical imaging confirms the high accumulation of AuS-U11 in the in situ pancreatic tumor model. Therapeutic studies further show that the combination of active targeting for tumor tissue, enzyme-triggered drug release of 5-ALA and fluorescent dye Cy5.5 in nanoclusters AuS-U11 could achieve optimal therapeutic efficacy with endomicroscopy-guided photothermal/photodynamic therapy with minimal side effects. As a consequence, the delicate gold nanocluster concept provides a promising strategy to enhance the therapy efficiency in the most challenging PDAC treatment.

Graphical abstract

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In vivo stem cell tracking with imageable nanoparticles that bind bioorthogonal chemical receptors on the stem cell surface

Publication date: September 2017
Source:Biomaterials, Volume 139
Author(s): Sangmin Lee, Hwa In Yoon, Jin Hee Na, Sangmin Jeon, Seungho Lim, Heebeom Koo, Sang-Soo Han, Sun-Woong Kang, Soon-Jung Park, Sung-Hwan Moon, Jae Hyung Park, Yong Woo Cho, Byung-Soo Kim, Sang Kyoon Kim, Taekwan Lee, Dongkyu Kim, Seulki Lee, Martin G. Pomper, Ick Chan Kwon, Kwangmeyung Kim
It is urgently necessary to develop reliable non-invasive stem cell imaging technology for tracking the in vivo fate of transplanted stem cells in living subjects. Herein, we developed a simple and well controlled stem cell imaging method through a combination of metabolic glycoengineering and bioorthogonal copper-free click chemistry. Firstly, the exogenous chemical receptors containing azide (-N3) groups were generated on the surfaces of stem cells through metabolic glycoengineering using metabolic precursor, tetra-acetylated N-azidoacetyl-d-mannosamine(Ac4ManNAz). Next, bicyclo[6.1.0]nonyne-modified glycol chitosan nanoparticles (BCN-CNPs) were prepared as imageable nanoparticles to deliver different imaging agents. Cy5.5, iron oxide nanoparticles and gold nanoparticles were conjugated or encapsulated to BCN-CNPs for optical, MR and CT imaging, respectively. These imageable nanoparticles bound chemical receptors on the Ac4ManNAz-treated stem cell surface specifically via bioorthogonal copper-free click chemistry. Then they were rapidly taken up by the cell membrane turn-over mechanism resulting in higher endocytic capacity compared non-specific uptake of nanoparticles. During in vivo animal test, BCN-CNP-Cy5.5-labeled stem cells could be continuously tracked by non-invasive optical imaging over 15 days. Furthermore, BCN-CNP-IRON- and BCN-CNP-GOLD-labeled stem cells could be efficiently visualized using in vivo MR and CT imaging demonstrating utility of our stem cell labeling method using chemical receptors. These results conclude that our method based on metabolic glycoengineering and bioorthogonal copper-free click chemistry can stably label stem cells with diverse imageable nanoparticles representing great potential as new stem cell imaging technology.

Graphical abstract

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Inside front cover

Publication date: July 2017
Source:International Immunopharmacology, Volume 48





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Well-defined single-chain polymer nanoparticles via thiol-Michael addition

Publication date: 30 June 2017
Source:Polymer, Volume 120
Author(s): A. Pia P. Kröger, Roy J.E.A. Boonen, Jos M.J. Paulusse
A synthetic strategy has been developed giving facile access to well-defined single-chain polymer nanoparticles (SCNPs) from styrene-, acrylate- and methacrylate-based polymers. Random copolymers (polydispersity indices 1.10–1.15) of methyl (meth)acrylate, benzyl methacrylate or styrene containing protected thiol monomers (xanthate and thioacetate vinyl monomers) were obtained via reversible addition–fragmentation chain transfer (RAFT) polymerization. Through aminolysis of the xanthate and thioacetate moieties, copolymers with free thiol moieties were obtained. The thiol bearing polymers were cross-linked with bifunctional acrylates under mild conditions. Precursor polymer dependent size-reductions between 30 and 90% were verified by gel permeation chromatography (GPC) measurements. Furthermore, the SCNPs were characterized by ¹H NMR, atomic force microscopy (AFM) and dynamic light scattering (DLS). Characteristic patterns for SCNPs were observed in the AFM phase mode. Thiol-Michael addition is demonstrated to be a versatile tool, which can easily be employed in the preparation of versatile well-defined functional polymer nanoparticles in the 3–10 nm size range.

Graphical abstract

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Innovative approach using aminomaleimide for unlocking phenolic diversity in high-performance maleimidobenzoxazine resins

Publication date: 30 June 2017
Source:Polymer, Volume 120
Author(s): Žiga Štirn, Aleš Ručigaj, Matjaž Krajnc
A new innovative synthetic approach for the preparation of maleimidobenzoxazines was developed. For the first time the phenolic diversity in maleimidobenzoxazine compounds was enabled, opening many possibilities for tailoring properties of maleimidobenzoxazines through phenolic diversity. The key in a successful implementation of a novel synthetic approach was utilization of aminomaleimide compound prepared by modified synthetic path, without the need for chromatographic purification. Yields of the reaction between aminomaleimide and phenols reached up to 95%, which is a significant improvement prior to previous studies dealing with maleimidobenzoxazines. Aminomaleimide and all novel maleimidobenzoxazine substances were characterized by ¹H NMR, ¹³C NMR and FTIR spectroscopies. The curing behaviour of prepared maleimidobenzoxazines was investigated by DSC analysis and mechanical properties by DMA analysis. Novel maleimidobenzoxazines showed similar properties comparing to the already presented in the literature showing high glass transition temperature values over 240 °C. Thermogravimetric analysis proved improved thermal stability of maleimidobenzoxazines compared to anilinobenzoxazines. Finally, the use of prepared maleimidobenzoxazines was investigated by the means of Diels-Alder reaction as a possible benzoxazine bearing maleimide group precursor for self-healing purposes.

Graphical abstract

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Long lasting prophylaxis of iodine deficiency after a successful information campaign for iodized salt consumption

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