Scholar : Molecular Medicine Reports - Volume:16 Number:4

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TABLE OF CONTENTS October-2017 Volume 16 Issue 4

Molecular mechanisms and potential prognostic effects of REST and REST4 in glioma (Review) Cuilin Li, Zhifei Wang, Xinyue Tang, Liu Zeng, Xitang Fan, Zhi Li View Abstract ❯

The role of T helper 17 cells in the pathogenesis of hepatitis B virus-related liver cirrhosis (Review) Suxia Bao, Jianming Zheng, Guangfeng Shi View Abstract ❯

Altered profile of mRNA expression in atrioventricular node of streptozotocin‑induced diabetic rats Frank Christopher Howarth, Khatija Parekh, Petrilla Jayaprakash, Edward Samuel Inbaraj, Murat Oz, Halina Dobrzynski, Thomas Edward Adrian View Abstract ❯

miR‑4262 inhibits colon cancer cell proliferation via targeting of GALNT4 Jian‑Jun Qu, Xiang‑Yang Qu, De‑Zhen Zhou View Abstract ❯

Investigation of the molecular mechanisms underlying myotonic dystrophy types 1 and 2 cataracts using microRNA‑target gene networks Dewang Shao, Xiaoquan Zhu, Wei Sun, Lu Huo, Wei Chen, Hua Wang, Bing Liu, Peng Pan View Abstract ❯

lncRNA expression character associated with ischemic reperfusion injury Xiaowei Wu, Hongyi Zhu, Suhua Zhu, Maojuan Hao, Qingping Li View Abstract ❯

Bcl‑2 associated athanogene 4 promotes proliferation, migration and invasion of gastric cancer cells Lizhi Yi, Zhenbing Lv, Jianmei Wang, Xianfei Zhong View Abstract ❯

Upregulation of long non-coding RNA DQ786243 promotes the progression of gastric cancer Ting Shan, Juanyun Fan, Qin Zhao, Kaiyuan Deng, Jiazeng Xia View Abstract ❯

Identification of key genes and pathways in Parkinson's disease through integrated analysis Jingru Wang, Yining Liu, Tuanzhi Chen View Abstract ❯

Integrated analysis of genome‑wide gene expression and DNA methylation microarray of diffuse large B‑cell lymphoma with TET mutations Pengfei Liu, Wenhua Jiang, Jinkun Zhao, Huilai Zhang View Abstract ❯

Co‑expression of Axin and APC gene fragments inhibits colorectal cancer cell growth via regulation of the Wnt signaling pathway Meili Xu, Xianling Liu, Yan Xu, Shicong Zhu, Yawen Gao View Abstract ❯

Gene therapy for human ovarian cancer cells using efficient expression of Fas gene combined with γδT cells Jiajing Lin, Dingyuan Zeng, Hongying He, Guangping Tan, Ying Lan, Fuyan Jiang, Shuting Sheng View Abstract ❯

Characterization and predicted role of microRNA expression profiles associated with early childhood obesity Shengrong Ouyang, Renqiao Tang, Zhuo Liu, Feifei Ma, Yuanyuan Li, Jianxin Wu View Abstract ❯

Atorvastatin protects cardiomyocytes against OGD/R‑induced apoptosis by inhibiting miR‑199a‑5p Yong Li, Ting Jiang, Xingli Fu, Hao Xu, Jianguo Ji View Abstract ❯

1,25(OH)2D3 treatment attenuates high glucose‑induced peritoneal epithelial to mesenchymal transition in mice Lina Yang, Yi Fan, Xiuli Zhang, Wenyu Huang, Jianfei Ma View Abstract ❯

MicroRNA‑329 serves a tumor suppressive role in colorectal cancer by directly targeting transforming growth factor beta‑1 Baohuan Li, Miaomiao Huang, Meiying Liu, Shiling Wen, Fang Sun View Abstract ❯

Protein kinase C isozyme expression in right ventricular hypertrophy induced by pulmonary hypertension in chronically hypoxic rats Chao Zeng, Bin Liang, Rui Jiang, Yiwei Shi, Yongcheng Du View Abstract ❯

Mori Folium water extract alleviates articular cartilage damages and inflammatory responses in monosodium iodoacetate‑induced osteoarthritis rats Jin‑Woo Jeong, Hye Hyeon Lee, Jongsik Kim, Eun‑Ok Choi, Hyun Hwang‑Bo, Hong Jae Kim, Min Young Kim, Kyu Im Ahn, Gi‑Young Kim, Ki Won Lee, Ki Young Kim, Sung Goo Kim, Su Hyun Hong, Cheol Park, Hee‑Jae Cha, Yung Hyun Choi View Abstract ❯

Expression profile of C19MC microRNAs in placental tissue of patients with preterm prelabor rupture of membranes and spontaneous preterm birth Ilona Hromadnikova, Katerina Kotlabova, Katarina Ivankova, Ladislav Krofta View Abstract ❯

The Toll-like receptor 4 antagonist TAK-242 protects against chronic pancreatitis in rats Long‑Fei Pan, Lei Yu, Li‑Ming Wang, Jun‑Tao He, Jiang‑Li Sun, Xiao‑Bo Wang, Zheng‑Hai Bai, Hai Wang, Ting‑Lin Yan, Hong‑Hong Pei View Abstract ❯

Inhibition of ARC promoting the apoptosis of rat pulmonary arterial smooth muscle cells after serum deprivation in vitro Jie Zhang, Zeyu Wu, Ming Guan, Hongyan Lu, Xuming Mo View Abstract ❯

Comparison of the neuronal differentiation abilities of bone marrow‑derived and adipose tissue‑derived mesenchymal stem cells Yani Zheng, Chao Huang, Fang Liu, Haiyan Lin, Xiangqun Yang, Zhiying Zhang View Abstract ❯

IL‑33 restricts invasion and adhesion of trophoblast cell line JEG3 by downregulation of integrin α4β1 and CD62L Xiao‑Hui Wang, Wei Liu, Deng‑Xuan Fan, Wen‑Ting Hu, Ming‑Qing Li, Xiao‑Yong Zhu, Li‑Ping Jin View Abstract ❯

Ganoderic acid A inhibits proliferation and invasion, and promotes apoptosis in human hepatocellular carcinoma cells Xu Wang, Di Sun, Jiandong Tai, Lei Wang View Abstract ❯

Effects of Shu Gan Jian Pi formula on rats with carbon tetrachloride‑induced liver fibrosis using serum metabonomics based on gas chromatography‑time of flight mass spectrometry Hui Jiang, Xiu‑Juan Qin, Wei‑Ping Li, Rong Ma, Ting Wang, Zhu‑Qing Li View Abstract ❯

In vitro reconstitution of interactions in the CARD9 signalosome Jin Hee Park, Jae Young Choi, Mir Faisal Mustafa, Hyun Ho Park View Abstract ❯

Precise epitope determination of the anti-vimentin monoclonal antibody V9 Lucia Tomiyama, Hiroki Kamino, Hiroki Fukamachi, Takeshi Urano View Abstract ❯

Hyperbaric oxygen alleviates the activation of NLRP‑3‑inflammasomes in traumatic brain injury Huihui Qian, Qinghe Li, Woda Shi View Abstract ❯

Identification of pivotal genes and pathways for spinal cord injury via bioinformatics analysis Zonghao Zhu, Qiang Shen, Liang Zhu, Xiaokang Wei View Abstract ❯

Analysis of microbial community composition and diversity in postoperative intracranial infection using high‑throughput sequencing Lixin Ruan, Daowu Wu, Xinchong Li, Qichuan Huang, Laipeng Lin, Jie Lin, Lie Chen, Peisong Xu, Jie Jin, Ningmin Yang, Xianfeng Li View Abstract ❯

Marine collagen peptides reduce endothelial cell injury in diabetic rats by inhibiting apoptosis and the expression of coupling factor 6 and microparticles Cuifeng Zhu, Wei Zhang, Jianguo Liu, Bo Mu, Fan Zhang, Nannan Lai, Jianxin Zhou, Aimin Xu, Yong Li View Abstract ❯

Beclin 1 overexpression inhibits chondrocyte apoptosis and downregulates extracellular matrix metabolism in osteoarthritis Bin Song, Hong Song, Weiguo Wang, Hongru Wang, Hanyuan Peng, Jing Cui, Rong Wang, Hua Huang, Wei Wang, Lili Wang View Abstract ❯

Aliskiren has chondroprotective efficacy in a rat model of osteoarthritis through suppression of the local renin-angiotensin system Kaizhong Yan, Yixin Shen View Abstract ❯

Anti-CD20 monoclonal antibody combined with adenovirus vector-mediated IL-10 regulates spleen CD4+/CD8+ T cells and T-bet/GATA-3 expression in NOD mice Aiping Tang, Cheng Li, Zhihong Chen, Tang Li View Abstract ❯

Associations of adiponectin receptor 2 (AdipoR2) gene polymorphisms and AdipoR2 protein expression levels with the risk of colorectal cancer: A case-control study Lei Zhou, Hai‑Feng Zhang, Wu Ning, Xin Song, Xin Liu, Ji‑Xi Liu View Abstract ❯

Osteoclast regulation of osteoblasts via RANK‑RANKL reverse signal transduction in vitro Shiqian Zhang, Xiaoyu Wang, Guojun Li, Yang Chong, Jie Zhang, Xinzhen Guo, Baoxin Li, Zhenggang Bi View Abstract ❯

Bombyx mori hemocyte extract has anti-inflammatory effects on human phorbol myristate acetate-differentiated THP‑1 cells via TLR4-mediated suppression of the NF-κB signaling pathway Young Il Kim, Kwang Ho Choi, Seong Ryul Kim, Tae‑Won Goo, Seung‑Won Park View Abstract ❯

Electric field exposure promotes epithelial‑mesenchymal transition in human lens epithelial cells via integrin β1‑FAK signaling Jun Liu, Xiao‑Long Yan, Xiao‑Liang Zheng, Lin Mei, Song Wang, Jing Han, Hong Yan View Abstract ❯

Production of bFGF monoclonal antibody and its inhibition of metastasis in Lewis lung carcinoma Yanqing Yang, Zhenming Luo, Yiyang Qin, Yu Zhou, Longcai Gong, Jianfang Huang, Hong Wang View Abstract ❯

Downregulation of SMP30 in senescent human lens epithelial cells Shuning Li, Xi Chen, Weixia Lai, Meixia Hu, Xin Zhong, Shaojian Tan, Hao Liang View Abstract ❯

Rapamycin inhibits spermatogenesis by changing the autophagy status through suppressing mechanistic target of rapamycin-p70S6 kinase in male rats Shangjing Liu, Longxian Huang, Yanqing Geng, Junlin He, Xuemei Chen, Hao Xu, Rong Li, Yingxiong Wang, Yubin Ding, Xueqing Liu View Abstract ❯

Screening of the prognostic targets for breast cancer based co-expression modules analysis Huijuan Liu, Hui Ye View Abstract ❯

The anti-inflammatory effects of Yunnan Baiyao are involved in regulation of the phospholipase A2/arachidonic acid metabolites pathways in acute inflammation rat model Xiaobin Ren, Mingzhu Zhang, Lingxiang Chen, Wanli Zhang, Yu Huang, Huazhen Luo, Ling Li, Hongbing He View Abstract ❯

EDIL3 knockdown inhibits retinal angiogenesis through the induction of cell cycle arrest in vitro Wei Shen, Shanbang Zhu, Haifeng Qin, Ming Zhong, Jinhui Wu, Rui Zhang, Hongyuan Song View Abstract ❯

Suppression of hepatic dysfunction in tenascin‑X‑deficient mice fed a high‑fat diet Shinsaku Yamaguchi, Kohei Kawakami, Kazumi Satoh, Naoki Fukunaga, Kazuhito Akama, Ken‑Ichi Matsumoto View Abstract ❯

MRI reveals slow clearance of dead cell transplants in mouse forelimb muscles Yanhui Zhang, Hongyan Zhang, Lijun Ding, Hailu Zhang, Pengli Zhang, Haizhen Jiang, Bo Tan, Zongwu Deng View Abstract ❯

STRA6 as a possible candidate gene for pathogenesis of osteoporosis from RNA‑seq analysis of human mesenchymal stem cells Insun Song, Yong Jun Choi, Yilan Jin, Jung‑Woo Kim, Jeong‑Tae Koh, Hyung Min Ji, Seon‑Yong Jeong, Ye‑Yeon Won, Won Kim, Yoon‑Sok Chung View Abstract ❯

Platelet-rich plasma exhibits beneficial effects for rheumatoid arthritis mice by suppressing inflammatory factors Shichao Tong, Changqing Zhang, Ji Liu View Abstract ❯

c-Myc promotes tumor proliferation and anti‑apoptosis by repressing p21 in rhabdomyosarcomas Jinghang Zhang, Na Song, Dan Zang, Jian Yu, Jinsong Li, Wenyu Di, Ruina Guo, Weixing Zhao, Haijun Wang View Abstract ❯

Adipose‑derived stem cells and hyaluronic acid based gel compatibility, studied in vitro Jiayan Guo, Shu Guo, Yuxin Wang, Yanqiu Yu View Abstract ❯

Homeobox‑containing protein 1 loss is associated with clinicopathological performance in glioma Ping Zhang, Qinglin Liu, Shaofeng Yan, Guang Yuan, Jie Shen, Gang Li View Abstract ❯

Long non‑coding RNA AK001796 contributes to cisplatin resistance of non‑small cell lung cancer Bin Liu, Chun‑Feng Pan, Teng Ma, Jun Wang, Guo‑Liang Yao, Ke Wei , Yi‑Jiang Chen View Abstract ❯

IL-12 induces autophagy in human breast cancer cells through AMPK and the PI3K/Akt pathway Yan Lin, Wenbin Kuang, Bitao Wu, Changli Xie, Cuiyin Liu, Zhiguang Tu View Abstract ❯

miR-127 contributes to ventilator-induced lung injury Qian Li, Ya‑Li Ge, Min Li, Xiang‑Zhi Fang, Yan‑Ping Yuan, Lei Liang, Shao‑Qiang Huang View Abstract ❯

FGF18 inhibits MC3T3‑E1 cell osteogenic differentiation via the ERK signaling pathway Feng Zhai, Na Song, Jisheng Ma, Weiyue Gong, Haishan Tian, Xiaokun Li, Chao Jiang, Haijun Wang View Abstract ❯

MicroRNA‑494 inhibits nerve growth factor‑induced cell proliferation by targeting cyclin D1 in human corneal epithelial cells Dan Wu, Tingting Qian, Jiaxu Hong, Gang Li, Weiyun Shi, Jianjiang Xu View Abstract ❯

miR‑132 in atrial fibrillation directly targets connective tissue growth factor Gang Qiao, Dongsheng Xia, Zhaoyun Cheng, Guobao Zhang View Abstract ❯

Pidotimod exacerbates allergic pulmonary infection in an OVA mouse model of asthma Luo‑Qin Fu, Ya‑Li Li, Ai‑Kun Fu, Yan‑Ping Wu, Yuan‑Yuan Wang, Sheng‑Lan Hu, Wei‑Fen Li View Abstract ❯

LCMR1 interacts with DEK to suppress apoptosis in lung cancer cells Yang Xu, Zhixin Liang, Chunsun Li, Zhen Yang, Liangan Chen View Abstract ❯

Effects of microRNA-26b on proliferation and invasion of glioma cells and related mechanisms Yun‑Ping Li, Wei‑Min Dai, Qiang Huang, Yuan‑Qing Jie, Guo‑Feng Yu, Xiao‑Feng Fan, An Wu, Dan‑Dan Mao View Abstract ❯

Human cytomegalovirus miR-US4-5p promotes apoptosis via downregulation of p21-activated kinase 2 in cultured cells Yaozhong Shao, Ying Qi, Yujing Huang, Zhongyang Liu, Yanping Ma, Xin Guo, Shujuan Jiang, Zhengrong Sun, Qiang Ruan View Abstract ❯

Identification of miRNA-mRNA crosstalk in laryngeal squamous cell carcinoma Yonghua Fei, Ping Guo, Fuling Wang, Hu Li, Yanhua Lei, Wei Li, Xuehong Xun, Fengxiang Lu View Abstract ❯

RAGE antagonism by FPS‑ZM1 attenuates postoperative cognitive dysfunction through inhibition of neuroinflammation in mice Haibin Zhou, Ting Luo, Changwei Wei, Wenzhen Shen, Ruilin Li, Anshi Wu View Abstract ❯

Oligomeric proanthocyanidins inhibit apoptosis of chondrocytes induced by interleukin-1β Meng‑Hong Yin, Yi‑Teng Wang, Qing Li, Guo‑Feng Lv View Abstract ❯

Fine particulate matter aggravates allergic airway inflammation through thymic stromal lymphopoietin activation in mice Yan Liu, Gan‑Zhu Feng, Qiang Du, Xiao‑Xiang Jin, Xing‑Ran Du View Abstract ❯

Effects of reduced β2 glycoprotein I on high glucose‑induced cell death in HUVECs Jing‑Yun Zhang, Jun Ma, Pei Yu, Guang‑Jie Tang, Chun‑Jun Li, De‑Min Yu, Qiu‑Mei Zhang View Abstract ❯

Endothelial semaphorin 7A promotes seawater aspiration-induced acute lung injury through plexin C1 and β1 integrin Minlong Zhang, Xue Yan, Wei Liu, Ruilin Sun, Yonghong Xie, Faguang Jin View Abstract ❯

Isolation and purification of novel peptides derived from Sepia ink: Effects on apoptosis of prostate cancer cell PC‑3 Fangfang Huang, Yinwen Jing, Guofang Ding, Zuisu Yang View Abstract ❯

Hispidin rescues palmitate‑induced insulin resistance in C2C12 myotubes Jong Seok Lee, Jun Myoung Park, Sarah Lee, Hye Jin Lee, Hee‑Sun Yang, Joohong Yeo, Ki Rim Lee, Byung Hyun Choi, Eock Kee Hong View Abstract ❯

Lutein protects against severe traumatic brain injury through anti‑inflammation and antioxidative effects via ICAM‑1/Nrf‑2 Dianhui Tan, Xiaoping Yu, Moran Chen, Junchen Chen, Jincheng Xu View Abstract ❯

A homozygous MYO7A mutation associated to Usher syndrome and unilateral auditory neuropathy spectrum disorder Hong Xia, Pengzhi Hu, Lamei Yuan, Wei Xiong, Hongbo Xu, Junhui Yi, Zhijian Yang, Xiong Deng, Yi Guo, Hao Deng View Abstract ❯

Protein interacting with C‑kinase 1 modulates exocytosis and KATP conductance in pancreatic β cells Yunhong Li, Fan Li, Bin Bai, Zhenyong Wu, Xiaolin Hou, Ying Shen, Yin Wang View Abstract ❯

Isorhamnetin inhibits IL‑1β‑induced expression of inflammatory mediators in human chondrocytes Jin Li, Ruishan Wu, Xiaoping Qin, Dongyang Liu, Fenjie Lin, Qinglu Feng View Abstract ❯

Acute and chronic effects of taurine magnesium coordination compound on cardiac sodium channel Nav1.5 Lin Zhao, Xiao‑Xu Yang, Yong‑Qiang Yin, Hong Wu, Yi Kang, Jian‑Shi Lou View Abstract ❯

Inhibitory effects of FKBP14 on human cervical cancer cells Lian‑Yi Sun, Jiu‑Zhi Tao, Bing Yan, Jian‑Shu Lin View Abstract ❯

Non-coding RNA 886 promotes renal cell carcinoma growth and metastasis through the Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway Jun Lei, Ju‑Hua Xiao, Shou‑Hua Zhang, Zhi‑Qiang Liu, Kai Huang, Zhi‑Peng Luo, Xin‑Lan Xiao, Zheng‑Dong Hong View Abstract ❯

MicroRNA‑613 inhibits proliferation and invasion of renal cell carcinoma cells through targeting FZD7 Haitao Song, Yonghao Nan, Xinsheng Wang, Gang Zhang, Shi Zong, Xiangbo Kong View Abstract ❯

Associations between mutations of the cell cycle checkpoint kinase 2 gene and gastric carcinogenesis Yan Hong, Jun Shi, Zhijun Ge, Haorong Wu View Abstract ❯

Upregulation of microRNA-25-3p inhibits proliferation, migration and invasion of osteosarcoma cells in vitro by directly targeting SOX4 Xiaolin Wu, Hongzhong Zhou, Bin Yue, Maohua Li, Fengxia Liu, Chensheng Qiu, Bohua Chen, Xuexiao Ma View Abstract ❯

Metabolic characteristics of Rhizoma Coptidis intervention in spontaneously hypertensive rats: Insights gained from metabolomics analysis of serum Wenqing Yang, Yue Deng, Honglei Zhou, Haiqiang Jiang, Yunlun Li, Yangjun Chu, Xiaoming Wang, Lili Gong View Abstract ❯

Upregulation of nuclear factor‑κB and acid sensing ion channel 3 in dorsal root ganglion following application of nucleus pulposus onto the nerve root in rats Dong Wang, Hao Pan, Hang Zhu, Li Zhu, Yong‑Jiang He, Jian Wang, Gao‑Yong Jia View Abstract ❯

Curcumin prevents lipopolysaccharide-induced matrix metalloproteinase‑2 activity via the Ras/MEK1/2 signaling pathway in rat vascular smooth muscle cells Yi Zhong, Jian Feng, Jiafu Li, Zhongcai Fan View Abstract ❯

Investigation of the immunomodulatory activity of Tricholoma matsutake mycelium in cyclophosphamide-induced immunosuppressed mice Quan Li, Yanzhen Wang, Yiling Chen, Meiyu Teng, Jian He, Xiaohan Wang, Fange Kong, Lirong Teng, Di Wang View Abstract ❯

miR‑21 promotes α‑SMA and collagen I expression in hepatic stellate cells via the Smad7 signaling pathway Rong‑Quan Fu, Dan‑Ping Hu, Yi‑Bing Hu, Liang Hong, Qing‑Feng Sun, Ji‑Guang Ding View Abstract ❯

Hypotonic contrast media is more toxic than isotonic contrast media on endothelial cells in vivo and in vitro Lihui Ren, Ping Wang, Zuoyan Wang, Yong Liu, Shuzheng Lv View Abstract ❯

Follistatin-like protein 1 increases transepithelial resistance in kidney epithelial cells through Akt signaling Fei Chen, Qiang Hu, Huihui Huang, Binbin Chen, Yin Xia, Wenjing Liu View Abstract ❯

Downregulation of microRNA-143 promotes cell proliferation by regulating PKCε in hepatocellular carcinoma cells Hanqiu Tang, Xiaotao Li, Rui Yang View Abstract ❯

IL‑6/STAT3/miR‑34a protects against neonatal lung injury patients Huajun Liu, Wenbin Liu, Xueqing Tang, Taisen Wang, Xianlin Sun, Jie Lv View Abstract ❯

Anti‑inflammatory effects on murine macrophages of ethanol extracts of Lygodium japonicum spores via inhibition of NF‑κB and p38 Young‑Chang Cho, Ba Reum Kim, Hien Thi Thu Le, Sayeon Cho View Abstract ❯

Implications of white matter damage in amyotrophic lateral sclerosis (Review) Ting Zhou, Tina Khorshid Ahmad, Kiana Gozda, Jessica Truong, Jiming Kong, Michael Namaka View Abstract ❯

Classical VEGF, Notch and Ang signalling in cancer angiogenesis, alternative approaches and future directions (Review) Nunzia Caporarello, Gabriella Lupo, Melania Olivieri, Martina Cristaldi, Maria Teresa Cambria, Mario Salmeri, Carmelina Daniela Anfuso View Abstract ❯

Role of the ACE2‑Ang‑(1‑7)‑Mas axis in blood pressure regulation and its potential as an antihypertensive in functional foods (Review) Shiqi Lin, Huanglei Pan, Hongli Wu, Difeng Ren, Jun Lu View Abstract ❯

Melatonin counteracts cobalt nanoparticle‑induced cytotoxicity and genotoxicity by deactivating reactive oxygen species‑dependent mechanisms in the NRK cell line Yake Liu, Xiaoyou Yang, Wei Wang, Xuefei Wu, Hai Zhu, Fan Liu View Abstract ❯

Anti-inflammatory effect of tribulusamide D isolated from Tribulus terrestris in lipopolysaccharide-stimulated RAW264.7 macrophages Hyun Hwa Lee, Eun‑Kyung Ahn, Seong‑Su Hong, Joa Sub Oh View Abstract ❯

Establishment of a murine pancreatic cancer pain model and microarray analysis of pain‑associated genes in the spinal cord dorsal horn Liqin Wang, Huihong Xu, Yanhu Ge, Hai Zhu, Dawei Yu, Weifeng Yu, Zhijie Lu View Abstract ❯

Histone demethylase PHF8 accelerates the progression of colorectal cancer and can be regulated by miR-488 in vitro Yao Lv, Yan Shi, Quanli Han, Guanghai Dai View Abstract ❯

Effects of combined general-epidural anesthesia and total intravenous anesthesia on cellular immunity and prognosis in patients with non‑small cell lung cancer: A comparative study Qiang Xu, Nian‑Jun Shi, Hao Zhang, Yan‑Mei Zhu View Abstract ❯

Curcumin attenuates the development of thoracic aortic aneurysm by inhibiting VEGF expression and inflammation Xiang Li, Qin Fang, Xiaohong Tian, Xiaohong Wang, Qiang Ao, Weijian Hou, Hao Tong, Jun Fan, Shuling Bai View Abstract ❯

Overexpression of long non-coding RNA differentiation antagonizing non-protein coding RNA inhibits the proliferation, migration and invasion and promotes apoptosis of renal cell carcinoma Lu Jin, Huifang Fu, Jing Quan, Xiang Pan, Tao He, Jia Hu, Yifan Li, Hang Li, Yu Yang, Jing Ye, Fangting Zhang, Liangchao Ni, Shangqi Yang, Yongqing Lai View Abstract ❯

Diverse gene expression patterns in response to anticancer drugs between human and mouse cell lines revealed by a comparative transcriptomic analysis Yong Guo, Zhuoran Liang, Xiaoliang Hou, Zhi Zhang View Abstract ❯

PCDH9 acts as a tumor suppressor inducing tumor cell arrest at G0/G1 phase and is frequently methylated in hepatocellular carcinoma Jun Lv, Pengfei Zhu, Xiaolei Zhang, Ling Zhang, Xiangmei Chen, Fengmin Lu, Zujiang Yu, Shuang Liu View Abstract ❯

Synergistic effects of fibroblast growth factor-2 and bone morphogenetic protein-2 on bone induction Rongying Song, Dingding Wang, Rong Zeng, Ju Wang View Abstract ❯

MRI detects protective effects of DAPT treatment with modulation of microglia/macrophages at subacute and chronic stages following cerebral ischemia Xiao‑Zhu Hao, Jia‑Qi Tian, Le‑Kang Yin, Xiao‑Xue Zhang, Chan‑Chan Li, Xiao‑Yuan Feng, Zhen‑Wei Yao, Min Jiang, Yan‑Mei Yang View Abstract ❯

MicroRNA-1291 promotes endometrial fibrosis by regulating the ArhGAP29-RhoA/ROCK1 signaling pathway in a murine model Qian Xu, Hua Duan, Lu Gan, Xin Liu, Fang Chen, Xue Shen, Yi‑Qun Tang, Sha Wang View Abstract ❯

T cell inhibition by pogostone from Pogostemon cablin (Blanco) Benth: In vitro and in vivo immunosuppressive analysis Jiyan Su, Jingjin He, Ziren Su, Lian Zhou, Yaoying Zeng, Xiaoping Lai, Yucui Li View Abstract ❯

Amyloid β-42 induces neuronal apoptosis by targeting mitochondria Xiao‑Jian Han, Yang‑Yang Hu, Zhang‑Jian Yang, Li‑Ping Jiang, Sheng‑Lan Shi, Ye‑Ru Li, Miao‑Yu Guo, Hong‑Li Wu, Yu‑Ying Wan View Abstract ❯

Time-series expression profile analysis of fracture healing in young and old mice Chun Yuan, Jinfang Cai View Abstract ❯

Telmisartan improves vascular remodeling through ameliorating prooxidant and profibrotic mechanisms in hypertension via the involvement of transforming growth factor-β1 Peijin Shang, Tianlong Liu, Wenxing Liu, Yuwen Li, Fang Dou, Yikai Zhang, Lijuan Sun, Tiejun Zhang, Zhihui Zhu, Fei Mu, Yi Ding, Aidong Wen View Abstract ❯

Lercanidipine attenuates angiotensin II-induced cardiomyocyte hypertrophy by blocking calcineurin-NFAT3 and CaMKII-HDAC4 signaling Yuezhang Chen, Jie Yuan, Guoliang Jiang, Jianbing Zhu, Yunzeng Zou, Qianzhou Lv View Abstract ❯

Influenza virus non‑structural protein 1 inhibits the production of interferon β of alveolar epithelial cells upon the infection of influenza A H1N1 Hao Jiang, Si‑Mei Shen, Jie Yin, Peng‑Peng Zhang, Yi Shi View Abstract ❯

Molecular dynamics simulations of human E3 ubiquitin ligase Parkin Shi Qiu, Shun Zhu, Shan Xu, Yanyan Han, Wen Liu, Ji Zuo View Abstract ❯

Rab5a is overexpressed in oral cancer and promotes invasion through ERK/MMP signaling Di Zhang, Changlong Lu, Hongjun Ai View Abstract ❯

Grb2-associated binder 2 expression and its roles in uveal melanoma invasion Meiling Chen, Yuehua Li, Xiuning Sun, Baogang Zhang, Wei Li, Shuxiao Wang, Xuetao Zhu, Feng Li, Lihong Shi View Abstract ❯

Identification of the active compounds and significant pathways of yinchenhao decoction based on network pharmacology Jihan Huang, Fan Cheung, Hor‑Yue Tan, Ming Hong, Ning Wang, Juan Yang, Yibin Feng, Qingshan Zheng View Abstract ❯

CD147 blockade as a potential and novel treatment of graft rejection Jing Luan, Yu Zhao, Yang Zhang, Jinlin Miao, Jia Li, Zhi‑Nan Chen, Ping Zhu View Abstract ❯

PIM-1 kinase inhibitor SMI-4a exerts antitumor effects in chronic myeloid leukemia cells by enhancing the activity of glycogen synthase kinase 3β Rui‑Fang Fan, Ying Lu, Zhi‑Gang Fang, Xiao‑Yan Guo, Yu‑Xin Chen, Yi‑Chuan Xu, Ya‑Mei Lei, Ke‑Fang Liu, Dong‑Jun Lin, Ling‑Ling Liu, Xiang‑Fu Liu View Abstract ❯

TRPC1 stimulates calcium‑sensing receptor‑induced store‑operated Ca2+ entry and nitric oxide production in endothelial cells Yuan‑Yuan Qu, La‑Mei Wang, Hua Zhong, Yong‑Min Liu, Na Tang, Li‑Ping Zhu, Fang He, Qing‑Hua Hu View Abstract ❯

Downregulation of CCL2 induced by the upregulation of microRNA-206 is associated with the severity of HEV71 encephalitis Guangyou Zhang, Jiwen Wang, Guo Yao, Baohai Shi View Abstract ❯

Two novel cross‑protective antigens for bovine Pasteurella multocida Huihui Du, Chenlu Wu, Chunming Li, Rendong Fang, Jianwei Ma, Jiale Ji, Zhihong Li, Nengzhang Li, Yuanyi Peng, Zeyang Zhou View Abstract ❯

HPK1 positive expression associated with longer overall survival in patients with estrogen receptor-positive invasive ductal carcinoma‑not otherwise specified Jiaojiao Wang, Lijie Song, Sen Yang, Weijie Zhang, Pengwei Lu, Shenglei Li, Huixiang Li, Liuxing Wang View Abstract ❯

Naringenin attenuates fibroblast activation and inflammatory response in a mechanical stretch-induced hypertrophic scar mouse model Shengzhou Shan, Yifan Zhang, Min Wu, Bo Yi, Jing Wang, Qingfeng Li View Abstract ❯

Altered gene expression profile in a rat model of gentamicin-induced ototoxicity and nephrotoxicity, and the potential role of upregulated Ifi44 expression Jun‑Gen Hu, Yu Fu, Jian‑Ju Xu, Xian‑Ping Ding, Hui‑Qi Xie, Jesse Li‑Ling View Abstract ❯

MicroRNA-21 regulates the proliferation and apoptosis of cervical cancer cells via tumor necrosis factor-α Lin Xu, Qian Xu, Xiwen Li, Xiaoling Zhang View Abstract ❯

Abnormal expression of HAX‑1 is associated with cellular proliferation and migration in human hypopharyngeal squamous cell carcinoma Hao Wu, Jianqiu Chen, Qiang Wang, Yong Yin, Peng Da, Huijun Le, Zhenxin Zhang, Xiaoxia Qiu View Abstract ❯

Molecular mechanisms of breast cancer metastasis by gene expression profile analysis Tianying Zheng, Aijun Wang, Dongyan Hu, Yonggang Wang View Abstract ❯

Nerve growth factor pretreatment inhibits lidocaine‑induced myelin damage via increasing BDNF expression and inhibiting p38 mitogen activation in the rat spinal cord Guangyi Zhao, Dan Li, Xudong Ding, Lu Li View Abstract ❯

Identification of key genes and pathways associated with classical Hodgkin lymphoma by bioinformatics analysis Zhixing Kuang, Li Guo, Xun Li View Abstract ❯

Knockdown of lncRNA HNF1A-AS1 inhibits oncogenic phenotypes in colorectal carcinoma Wenyi Zhu, Peipei Zhuang, Wen Song, Shiyu Duan, Qiong Xu, Man Peng, Jun Zhou View Abstract ❯

Dysregulation of zinc/lipid metabolism‑associated genes in the rat hippocampus and cerebral cortex in early adulthood following recurrent neonatal seizures Zhen‑Hong Li, Li‑Li Li, Mei‑Fang Jin, Xu‑Qin Chen, Qi Sun, Hong Ni View Abstract ❯

Curcumin prevents reperfusion injury following ischemic stroke in rats via inhibition of NF‑κB, ICAM-1, MMP-9 and caspase-3 expression Wei Li, Nijasri Charnnarong Suwanwela, Suthiluk Patumraj View Abstract ❯

Identification of long non-coding RNA 00312 and 00673 in human NSCLC tissues Qian Tan, Yalan Yu, Nandi Li, Wei Jing, Hu Zhou, Shili Qiu, Chunzi Liang, Mingxia Yu, Jiancheng Tu View Abstract ❯

Collagen type II is downregulated in the degenerative nucleus pulposus and contributes to the degeneration and apoptosis of human nucleus pulposus cells Chengjie Lian, Bo Gao, Zizhao Wu, Xianjian Qiu, Yan Peng, Anjing Liang, Caixia Xu, Peiqiang Su, Dongsheng Huang View Abstract ❯

Construction of a recombinant pIRES2-EGFP-ARTS plasmid and its effect on LX-2 cells Feifan Xu, Yuanlong Han, Dandan Zhu, Hua Tian, Huiming Zhu, Jingjing Ren, Delin Gu, Yinong Duan View Abstract ❯

In vitro effects of Staphylococcus aureus enterotoxin C3 on T cell activation, proliferation and cytokine production Yixin Xie, Min Wang, Zhihui Dong, Huan Song, Lianping Li, Min Yang, Pengling Li, Jingjing Tian, Kan Zhang, Xiaomeng Xia, Tingting Zhang, Aiguo Tang View Abstract ❯

Bestrophin 1 gene analysis and associated clinical findings in a Chinese patient with Best vitelliform macular dystrophy Ying Lin, Tao Li, Hongbin Gao, Yu Lian, Chuan Chen, Yi Zhu, Yonghao Li, Bingqian Liu, Wenli Zhou, Hongye Jiang, Xialin Liu, Xiujuan Zhao, Xiaoling Liang, Chenjin Jin, Xinhua Huang, Lin Lu View Abstract ❯

Atorvastatin increases Fads1, Fads2 and Elovl5 gene expression via the geranylgeranyl pyrophosphate-dependent Rho kinase pathway in 3T3-L1 cells Noriko Ishihara, Sawako Suzuki, Shou Tanaka, Yasuhiro Watanabe, Daiji Nagayama, Atsuhito Saiki, Tomoaki Tanaka, Ichiro Tatsuno View Abstract ❯

Differential expression of B-type natriuretic peptide between left and right ventricles, with particular regard to sudden cardiac death Zhi‑Peng Cao, Jia‑Jia Xue, Yuan Zhang, Mei‑Hui Tian, Ying Xiao, Yu‑Qing Jia, Bao‑Li Zhu View Abstract ❯

α7 nicotinic acetylcholine receptor agonist inhibits the damage of rat hippocampal neurons by TLR4/Myd88/NF‑κB signaling pathway during cardiopulmonary bypass Keyan Chen, Yingjie Sun, Yugang Diao, Liu Ji, Dandan Song, Tiezheng Zhang View Abstract ❯

TREM-2 negatively regulates LPS-mediated inflammatory response in rat bone marrow-derived MSCs Pei Ye, Dawei Xu, Jinhuang Xu, Guiwang Liu, Shenghui Huang, Weiqiong Zhang, Peizhong Zheng, Jianhua Li, Jianrong Huang View Abstract ❯

Individualized drug screening based on next generation sequencing and patient derived xenograft model for pancreatic cancer with bone metastasis Zhonghai Guan, Huanrong Lan, Xiangheng Chen, Xiaoxia Jiang, Xuanwei Wang, Ketao Jin View Abstract ❯

Protective effect of diminazene attenuates myocardial infarction in rats via increased inflammation and ACE2 activity Junjiang Chen, Lianqun Cui, Jingliang Yuan, Songcun Zhang, Rongmei Ma, Hongjun Sang, Qingjiang Liu, Lianfeng Shan View Abstract ❯

The impact of HuD protein on the intestinal nervous system in the terminal rectum of animal models of congenital anorectal malformation Meng Kong, Yurui Wu, Yuanmei Liu View Abstract ❯

Bioinformatic analysis of microRNA-mRNA expression profiles of bladder tissue induced by bladder outlet obstruction in a rat model Liu Jian Duan, Qi Feng Cao, Ding Xu, Hai Long Liu, Jun Qi View Abstract ❯

Disorder of the mevalonate pathway inhibits calcium-induced differentiation of keratinocytes Rui Jin, Xin Luo, Kang Luan, Li Liu, Liang‑Dan Sun, Sen Yang, Sheng‑Quan Zhang, Xue‑Jun Zhang View Abstract ❯

Beneficial effect of magnolol on lupus nephritis in MRL/lpr mice by attenuating the NLRP3 inflammasome and NF‑κB signaling pathway: A mechanistic analysis Feng Huang, Rui‑Yun Zhang, Lei Song View Abstract ❯

In silico design of colchicine-based bioisosteric inhibitors of tubulin for the treatment of rheumatoid arthritis Li Wang, Hao‑Jie Yang, Ran Tu, Min Shen, Dan Liu View Abstract ❯

MicroRNA-635 inhibits the malignancy of osteosarcoma by inducing apoptosis Linqiang Tian, Zhihao Guo, Hongwei Wang, Xiaotan Liu View Abstract ❯

Transcription of seven genes in a model of interferon‑γ-induced persistent Chlamydia psittaci infection Zhixi Chen, Lili Chen, Chuan Wang, Jian Yu, Qinqin Bai, Minjun Yu, Yin Song, Yanqun Hu, Yimou Wu View Abstract ❯

microRNA‑630 promotes cell proliferation and inhibits apoptosis in the HCT116 human colorectal cancer cell line Lijuan Zhang, Gang Feng, Xinyan Zhang, Yawen Ding, Xiaojuan Wang View Abstract ❯

PI3K/AKT signaling pathway activation in a rat model of migraine Yun‑Yong Liu, Zi‑Yao Jiao, Wei Li, Qian Tian View Abstract ❯

Reactive oxygen species modulator 1 regulates oxidative stress and induces renal and pulmonary fibrosis in a unilateral ureteral obstruction rat model and in HK‑2 cells Donghai Liu, Ying Liu, Zhenkun Xia, Haiyun Dong, Zhuwen Yi View Abstract ❯

miR-663 promotes NPC cell proliferation by directly targeting CDKN2A Shaoqiang Liang, Ning Zhang, Yanming Deng, Lusi Chen, Yang Zhang, Zhenhe Zheng, Weijun Luo, Zhiqian Lv, Shaoen Li, Tao Xu View Abstract ❯

Felodipine inhibits ox-LDL-induced reactive oxygen species production and inflammation in human umbilical vein endothelial cells Jie Qi, Jian‑Bao Zheng, Wen‑Ting Ai, Xiao‑Wei Yao, Lei Liang, Gong Cheng, Xi‑Ling Shou, Chao‑Feng Sun View Abstract ❯

Gold nanoparticles promote osteogenic differentiation of human periodontal ligament stem cells via the p38 MAPK signaling pathway Chenguang Niu, Keyong Yuan, Rui Ma, Li Gao, Wenxin Jiang, Xuchen Hu, Wenzhen Lin, Xiaoling Zhang, Zhengwei Huang View Abstract ❯

Long non‑coding RNA HOXA11‑AS promotes cell proliferation and metastasis in human breast cancer Jian‑Chun Su, Xue‑Feng Hu View Abstract ❯

Impacts of the serum containing total flavonoids of Ajuga on rat glomerular mesangial cells Lihong Nan, Mei Huang, Wenfang Lai, Ru Jia, Yanfang Zheng, Lan Yang, Qingqing Xie, Weihua Peng View Abstract ❯

Phylogenetic and specific sequence analysis of four paralogs in insect Aquaporins Wei Xia, Panwen Zhao, Zhongquan Yi, Yubao Cui View Abstract ❯

PEGylation of Lumbrokinase improves pharmacokinetic profile and enhances anti‑thrombotic effect in a rat carotid artery thrombosis model Mingji Jin, Guangming Jin, Wei Huang, Zhonggao Gao View Abstract ❯

Osthole protects against inflammation in a rat model of chronic kidney failure via suppression of nuclear factor-κB, transforming growth factor-β1 and activation of phosphoinositide 3-kinase/protein kinase B/nuclear factor (erythroid-derived 2)-like 2 signaling Tao Huang, Zhen Dong View Abstract ❯

Dioscin enhances osteoblastic cell differentiation and proliferation by inhibiting cell autophagy via the ASPP2/NF-κβ pathway Chen Zhu, Nirong Bao, Shuo Chen, Jianning Zhao View Abstract ❯

Curcumin analog EF24 induces apoptosis and downregulates the mitogen activated protein kinase/extracellular signal-regulated signaling pathway in oral squamous cell carcinoma Chongxiang Lin, Chengwei Tu, Yike Ma, Pengcheng Ye, Xia Shao, Zhaoan Yang, Yiming Fang View Abstract ❯

Elevated expression of yes‑associated protein is associated with the malignant status and prognosis of laryngeal squamous cell carcinoma Chunchen Pan, Zhihui Du, Zhaogen Cai, Yun Liu, Yanbo Sun, Jin Chen, Ting Tong, Qingguo Chen, Liangqiang Zhou, Dan Bing, Yanling Tao, Hanqi Chu View Abstract ❯

Ethanol extract of Antrodia camphorata inhibits proliferation of HCT-8 human colorectal cancer cells by arresting cell cycle progression and inducing apoptosis Gong Wang, Yun Wan, Jinyan Zhao, Zhenfeng Hong View Abstract ❯

Correlation analysis of surfactant protein A and surfactant protein D with lung function in exhaled breath condensate from lung cancer patients with and without COPD Xuefeng Lin, Zhenlin Wu, Yichu Fan, Mingyou Chi, Xiaodong Wang, Xun Zhang, Daqiang Sun View Abstract ❯

c‑Maf inducing protein inhibits cofilin‑1 activity and alters podocyte cytoskeleton organization Lixia Yu, Jianming Ye, Qifeng Liu, Jianhua Feng, Xiaoxia Gu, Qiang Sun, Guoyuan Lu View Abstract ❯

A20 protein regulates lipopolysaccharide-induced acute lung injury by downregulation of NF-κB and macrophage polarization in rats Ying Wang, Zhenju Song, Jing Bi, Jie Liu, Lin Tong, Yuanlin Song, Chunxue Bai, Xiaodan Zhu View Abstract ❯

Generation of a novel TRAIL mutant by proline to arginine substitution based on codon bias and its antitumor effects Aijing Zhu, Xiuyun Wang, Min Huang, Chen Chen, Juan Yan, Qi Xu, Lijia Wei, Xianzhou Huang, Hong Zhu, Cheng Yi View Abstract ❯

Knockdown of Hotair suppresses proliferation and cell cycle progression in hepatocellular carcinoma cell by downregulating CCND1 expression Jia‑Jia Zhou, Di Cheng, Xiao‑Yu He, Zhe Meng, Wen‑Zhu Li, Ru‑Fu Chen View Abstract ❯

Sigma-1 receptor activation ameliorates anxiety-like behavior through NR2A-CREB-BDNF signaling pathway in a rat model submitted to single-prolonged stress Li‑Li Ji, Jun‑Bo Peng, Chang‑Hai Fu, Lei Tong, Zhen‑Yu Wang View Abstract ❯

Danshensu attenuates aldosterone-induced cardiomyocytes injury through interfering p53 pathway Xiaohong Yang, Rui Yang, Xianli Li, Xiaohui Zheng View Abstract ❯

Stromal cell-derived factor 1 protects human periodontal ligament stem cells against hydrogen peroxide-induced apoptosis Yimiao Feng, Xiaohui Fu, Xintian Lou, Baiping Fu View Abstract ❯

MicroRNA-199b targets the regulation of ZEB1 expression to inhibit cell proliferation, migration and invasion in non‑small cell lung cancer Jin Wang, Fachen Zhou, Liu Yin, Lei Zhao, Yixiang Zhang, Jinguang Wang View Abstract ❯

SERCA1 attenuates diaphragm relaxation and uptake rate of SERCA in rats with acute sepsis Jianyou Zhang, Hui Liu, Shitong Li, Jin Wu, Jianhong Sun View Abstract ❯

Oncogenic miR-100-5p is associated with cellular viability, migration and apoptosis in renal cell carcinoma Peijie Chen, Canbin Lin, Jing Quan, Yulin Lai, Tao He, Liang Zhou, Xiang Pan, Xueling Wu, Yong Wang, Liangchao Ni, Shangqi Yang, Tao Wang, Yongqing Lai View Abstract ❯

E‑cadherin involvement in human lens epithelial cell transdifferentiation may be associated with N‑cadherin Lei Huang, Jie Jiang, Qiang Guo, Hongbin Yang View Abstract ❯

ILK promotes cell proliferation in breast cancer cells by activating the PI3K/Akt pathway Yikun Qu, Chunfang Hao, Jian Xu, Zhuoxin Cheng, Weiqun Wang, Hong Liu View Abstract ❯

Antidepressant-like effects of Marasmius androsaceus metabolic exopolysaccharides on chronic unpredictable mild stress-induced rat model Jia Song, Xue Wang, Yu Huang, Yidi Qu, Lesheng Teng, Di Wang, Zhaoli Meng View Abstract ❯

Oxidored-nitro domain-containing protein 1 promotes liver fibrosis by activating the Wnt/β-catenin signaling pathway in vitro Tianxin Xiang, Shouhua Zhang, Na Cheng, Shanfei Ge, Jiangxiong Wen, Juhua Xiao, Xiaoping Wu View Abstract ❯

MicroRNA‑744 inhibits tumor cell proliferation and invasion of gastric cancer via targeting brain‑derived neurotrophic factor Ai‑Jun Xu, Li‑Na Fu, Hua‑Xing Wu, Xiao‑Li Yao, Rui Meng View Abstract ❯

[Retracted] Effects of the eukaryotic initiation factor 6 gene on expression levels of inflammatory mediators in M2 macrophages during scar repair Yong‑Qiang Bai, Jian‑Ke Feng, Qing‑Fu Zhang, Hong‑Zhi Wu, Ya‑Ru Du, Wei Wei View Abstract ❯

Attention deficit hyperactivity disorder may be a highly inflammation and immune-associated disease (Review) Rong‑Yi Zhou, Jiao‑Jiao Wang, Ji‑Chao Sun, Yue You, Jing‑Nang Ying, Xin‑Min Han View Abstract ❯

Adhesion, proliferation and osteogenic differentiation of mesenchymal stem cells in 3D printed poly-ε-caprolactone/hydroxyapatite scaffolds combined with bone marrow clots Pengfei Zheng, Qingqiang Yao, Fengyong Mao, Nancy Liu, Yan Xu, Bo Wei, Liming Wang View Abstract ❯

Personalized identification of differentially expressed pathways in pediatric sepsis Binjie Li, Qiyi Zeng View Abstract ❯

Renal sympathetic denervation alleviates myocardial fibrosis following isoproterenol-induced heart failure Neng Wang, Xiaoxin Zheng, Jin Qian, Wei Yao, Lu Bai, Guo Hou, Xuan Qiu, Xiaoyan Li, Xuejun Jiang View Abstract ❯

A study of Sirt1 regulation and the effect of resveratrol on synoviocyte invasion and associated joint destruction in rheumatoid arthritis Liang Hao, Yuying Wan, Juhua Xiao, Qiang Tang, Huan Deng, Lu Chen View Abstract ❯

Effect of RNA interference of the expression of HMGA2 on the proliferation and invasion ability of ACHN renal cell carcinoma cells Ying Liu, Qi‑Zhong Fu, Lin Pu, Ling‑Ling Song, Yi‑Yun Wang, Jing Liu, Zhen‑Long Wang, Zi‑Ming Wang View Abstract ❯

Identification of an lncRNA‑miRNA‑mRNA interaction mechanism in breast cancer based on bioinformatic analysis Yuhan Zhang, Yongfeng Li, Qing Wang, Xiping Zhang, Dajin Wang, Hong Chao Tang, Xuli Meng, Xianfeng Ding View Abstract ❯

Emodin alleviates severe acute pancreatitis-associated acute lung injury by decreasing pre-B-cell colony-enhancing factor expression and promoting polymorphonuclear neutrophil apoptosis Hongzhang Cui, Shu Li, Caiming Xu, Jingwen Zhang, Zhongwei Sun, Hailong Chen View Abstract ❯

Microarray data re-annotation reveals specific lncRNAs and their potential functions in non-small cell lung cancer subtypes Dongbo Zhou, Mingxuan Xie, Baimei He, Ying Gao, Qiao Yu, Bixiu He, Qiong Chen View Abstract ❯

Regulatory effects and molecular mechanism of Trigonostemon reidioides on lipopolysaccharide‑induced inflammatory responses in RAW264.7 cells Ju Young Shin, Jae‑Shin Kang, Hye‑Woo Byun, Eun‑Kyung Ahn View Abstract ❯

Protective effects of Cervus nippon Temminck velvet antler polypeptides against MPP+‑induced cytotoxicity in SH‑SY5Y neuroblastoma cells Ji‑Le Xin, Yang Zhang, Yan Li, Lian‑Zhu Zhang, Yong Lin, Lian‑Wen Zheng View Abstract ❯

AKAP2 is upregulated in ovarian cancer, and promotes growth and migration of cancer cells Xin Li, Changjun Wang, Gang Zhang, Ming Liang, Bin Zhang View Abstract ❯

MicroRNA‑643 regulates the expression of ZEB1 and inhibits tumorigenesis in osteosarcoma Huan Wang, Danmou Xing, Dong Ren, Wei Feng, Yan Chen, Zhiming Zhao, Zhihong Xiao, Zhengren Peng View Abstract ❯

The effect of Bu Zhong Yi Qi decoction on simulated weightlessness‑induced muscle atrophy and its mechanisms Mu Zhu, Zhongyang Liu, Mingze Gao, Yan Zhang, Yuheng Li, Shukuan Ling, Pengfei Zhang, Chenyang Zhao, Lijun Jiang, Yu Liu, Qi Li, Dong Li, Sumin Hu, Yingxian Li View Abstract ❯

Expression of long non‑coding RNAs in chondrocytes from proximal interphalangeal joints Dong Lv, Changzheng Su, Zhen Li, Xingyu Chai, Zhengwen Xu, Tao Pang View Abstract ❯

FoxM1 promotes epithelial-mesenchymal transition of hepatocellular carcinoma by targeting Snai1 Chun‑Peng Yu, Shui Yu, Lei Shi, Song Wang, Zi‑Xiang Li, Yan‑Hua Wang, Cheng‑Jian Sun, Jun Liang View Abstract ❯

Maternal diabetes impairs the initiation of meiosis in murine female germ cells Xu‑Hua Qiu, Mei-Ling Li, Ng Li, Qin Sun, Ji Zhou, Ru‑Jun Ma, Ying Lin, Min Xie, Xie Ge, Li Chen, Bing Yao View Abstract ❯

Zinc inhibits high glucose-induced NLRP3 inflammasome activation in human peritoneal mesothelial cells Yi Fan, Xiuli Zhang, Lina Yang, Jun Wang, Ye Hu, Aishu Bian, Jin Liu, Jianfei Ma View Abstract ❯

Human hepatocyte growth factor inhibits early neointima formation in rabbit abdominal aortae following ultrasound-guided balloon injury Li Mei, Yu He, Hui Wang, Ying Jin, Shuai Wang, Chunxiang Jin View Abstract ❯

Saponin extract from Panax notoginseng promotesangiogenesis through AMPK‑ and eNOS‑dependent pathways in HUVECs Dongzhi Wang, Qiqiang Jie, Baoxin Liu, Yong Li, Liming Dai, Jiachen Luo, Lei Hou, Yidong Wei View Abstract ❯

Tetrahydroxy stilbene glucoside ameliorates H2O2-induced human brain microvascular endothelial cell dysfunction in vitro by inhibiting oxidative stress and inflammatory responses Zhao Jiang, Wenhong Wang, Chengcheng Guo View Abstract ❯

Betaine attenuates chronic alcohol‑induced fatty liver by broadly regulating hepatic lipid metabolism Wenjuan Yang, Luming Huang, Jinhang Gao, Shilei Wen, Yang Tai, Meng Chen, Zhiyin Huang, Rui Liu, Chengwei Tang, Jing Li View Abstract ❯

Overexpression of long non-coding RNA cancer susceptibility 2 inhibits cell invasion and angiogenesis in gastric cancer Jianfeng Zhou, Haiyan Huang, Shijie Tong, Rong Huo View Abstract ❯

MicroRNA-130a is upregulated in colorectal cancer and promotes cell growth and motility by directly targeting forkhead box F2 Wenzhong Chen, Kehui Tong, Jiren Yu View Abstract ❯

MicroRNA‑503 serves an oncogenic role in laryngeal squamous cell carcinoma via targeting programmed cell death protein 4 Yu Shuang, Xuan Zhou, Chao Li, Yongwang Huang, Lun Zhang View Abstract ❯

Modulation of the immune response in rheumatoid arthritis with strategically released rapamycin Ping Shao, Linxiao Ma, Yile Ren, Huijie Liu View Abstract ❯

Sepsis decreases the activity of acetylcholinesterase by reducing its expression at the neuromuscular junction Jin Wu, Tian Jin, Hong Wang, Shi‑Tong Li View Abstract ❯

Licochalcone E protects against carbon tetrachloride‑induced liver toxicity by activating peroxisome proliferator-activated receptor gamma Jichun Han, Dong Wang, Defang Li, Xiaoyu Chen, Bo Wang, Fenghua Wang, Xiaona Liu, Jing Shang, Qiusheng Zheng View Abstract ❯

Effects of hydrogen sulfide on inducible nitric oxide synthase activity and expression of cardiomyocytes in diabetic rats Rui Yang, Qiang Jia, Xiao‑Fen Liu, Yuan‑Yuan Wang, Shan‑Feng Ma View Abstract ❯

Immunolocalization of cannabinoid receptor type 1 and CB2 cannabinoid receptors, and transient receptor potential vanilloid channels in pterygium Martha Assimakopoulou, Dionysios Pagoulatos, Pinelopi Nterma, Nikolaos Pharmakakis View Abstract ❯

Endothelial progenitor cell dysfunction in acute exacerbation of chronic obstructive pulmonary disease Xiaoran Liu, Yangli Liu, Xinyan Huang, Gengpeng Lin, Canmao Xie View Abstract ❯

Effects of Tribulus terrestris on monosodium iodoacetate‑induced osteoarthritis pain in rats Young Jin Park, Young‑Rak Cho, Joa Sub Oh, Eun‑Kyung Ahn View Abstract ❯

Personalized analysis of pathway aberrance induced by sevoflurane and propofol Xianqiang Zheng, Jing Cong, Huidong Zhang, Xueliang Chu View Abstract ❯

Hydrogen saline suppresses neuronal cell apoptosis and inhibits the p38 mitogen‑activated protein kinase‑caspase‑3 signaling pathway following cerebral ischemia‑reperfusion injury Da Li, Yanqiu Ai View Abstract ❯

MicroRNA‑518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB Xiaolong Xu, Fenglin Zhang, Xianzhen Chen, Qi Ying View Abstract ❯

C278F mutation in FGFR2 gene causes two different types of syndromic craniosynostosis in two Chinese patients Ying Lin, Hongbin Gao, Siming Ai, Jacob V.P. Eswarakumar, Chuan Chen, Yi Zhu, Tao Li, Bingqian Liu, Xialin Liu, Lixia Luo, Hongye Jiang, Yonghao Li, Xiaoling Liang, Chenjin Jin, Xinhua Huang, Lin Lu View Abstract ❯

Sanggenon C protects against pressure overload‑induced cardiac hypertrophy via the calcineurin/NFAT2 pathway Lili Xiao, Yulei Gu, Lu Gao, Jiahong Shangguan, Yang Chen, Yanzhou Zhang, Ling Li View Abstract ❯

Methylation of mitochondrial DNA displacement loop region regulates mitochondrial copy number in colorectal cancer Huan Tong, Linhao Zhang, Jinhang Gao, Shilei Wen, Hongying Zhou, Shi Feng View Abstract ❯

Inhibitory effects of oxymatrine on TGF‑β1‑induced proliferation and abnormal differentiation in rat cardiac fibroblasts via the p38MAPK and ERK1/2 signaling pathways Yini Xu, Hai Xiao, Hong Luo, Yan Chen, Yanyan Zhang, Ling Tao, Yan Jiang, Yuqi Chen, Xiangchun Shen View Abstract ❯

Overexpressed microRNA-506 and microRNA-124 alleviate H2O2-induced human cardiomyocyte dysfunction by targeting krüppel-like factor 4/5 Xiuzhou Zhang, Fuyan Liu, Qingqing Wang, Yuxue Geng View Abstract ❯

Quercetin alleviates generalized hyperalgesia in mice with induced adenomyosis Jichan Nie, Xishi Liu View Abstract ❯

Suppressive effects of human fetal keratinocytes on the proliferation, differentiation and extracellular matrix synthesis of human hypertrophic scar fibroblasts in vitro Zhe Wang, Qibin Song, Hongqiu Li View Abstract ❯

Proteomic profiling of human HepG2 cells treated with hesperidin using antibody array Silvia Yumnam, Venu Venkatarame Gowda Saralamma, Suchismita Raha, Ho Jeong Lee, Won Sup Lee, Eun Kim Kim, Sang Joon Lee, Jeong Doo Heo, Gon Sup Kim View Abstract ❯

Downregulation of miR‑136‑5p in hepatocellular carcinoma and its clinicopathological significance Hua Ding, Zhi‑Hua Ye, Dong‑Yue Wen, Xiao‑Liang Huang, Chu‑Mei Zeng, Jie Mo, Yi‑Qiang Jiang, Jian‑Jun Li, Xiao‑Yong Cai, Hong Yang, Gang Chen View Abstract ❯

Effect of varicocelectomy treatment on spermatogenesis and apoptosis via the induction of heat shock protein 70 in varicocele‑induced rats Jin‑Zhuo Ning, Ting Rao, Fan Cheng, Wei‑Min Yu, Yuan Ruan, Run Yuan, Shao‑Ming Zhu, Yang Du, Cheng‑Cheng Xiao View Abstract ❯

Analysis of intestinal microbial communities of cerebral infarction and ischemia patients based on high throughput sequencing technology and glucose and lipid metabolism Wenzhen Ji, Yu Zhu, Pengcheng Kan, Ying Cai, Zhida Wang, Zijian Wu, Ping Yang View Abstract ❯

PML(NLS¯) protein: A novel marker for the early diagnosis of acute promyelocytic leukemia Zhi‑Ling Shan, Xin‑Yu Zhu, Peng‑Peng Ma, Hui Wang, Jianbin Chen, Jun Li, Liang Zhong, Bei‑Zhong Liu View Abstract ❯

Comparative proteomic analysis of rats subjected to water immersion and restraint stress as an insight into gastric ulcers Zheng‑Rong Zhou, Pan Huang, Guang‑Hao Song, Zhuang Zhang, Ke An, Han‑Wen Lu, Xiao‑Li Ju, Wei Ding View Abstract ❯

Downregulation of microRNA-195 promotes angiogenesis induced by cerebral infarction via targeting VEGFA Wen‑Jing Zhao, Hai‑Fang Zhang, Jin‑Ying Su View Abstract ❯

Angelicin inhibits liver cancer growth in vitro and in vivo Fengliang Wang, Jun Li, Rong Li, Guohua Pan, Mingxia Bai, Qiang Huang View Abstract ❯

Significance of the TMPRSS2:ERG gene fusion in prostate cancer Zhu Wang, Yuliang Wang, Jianwen Zhang, Qiyi Hu, Fan Zhi, Shengping Zhang, Dengqi Mao, Ying Zhang, Hui Liang View Abstract ❯

Upregulation of ADAMTS‑7 and downregulation of COMP are associated with aortic aneurysm Wei Qin, Yide Cao, Liangpeng Li, Wen Chen, Xin Chen View Abstract ❯

Human papillomavirus E6-regulated microRNA-20b promotes invasion in cervical cancer by targeting tissue inhibitor of metalloproteinase 2 Yuan Cheng, Li Geng, Lijun Zhao, Peng Zuo, Jianliu Wang View Abstract ❯

Autophagy may play an important role in varicocele Shao‑Ming Zhu, Ting Rao, Xiao Yang, Jin‑Zhuo Ning, Wei‑Ming Yu, Yuan Ruan, Run Yuan, Cheng‑Long Li, Kun Jiang, Wei Hu, Hao‑Yong Li, Fan Cheng View Abstract ❯

Plumbagin induces apoptosis in human osteosarcoma through ROS generation, endoplasmic reticulum stress and mitochondrial apoptosis pathway Chia‑Chia Chao, Sheng‑Mou Hou, Chieh Chen Huang, Chun‑Han Hou, Po‑Chun Chen, Ju‑Fang Liu View Abstract ❯

Long non-coding RNA Z38 promotes cell proliferation and metastasis in human renal cell carcinoma Xiangfei He, Hongjun Liu, Fengfu Guo, Yanfei Feng, Yisheng Gao, Fuguang Sun, Bin Song, Hua Lu, Yang Li View Abstract ❯

Clinicopathological analysis of 114 cases of typical Kaposi's sarcoma in Xinjiang Uygur autonomous region, China Jun‑Wei Fan, Xue‑Feng Wan, Bian Yi, Jin‑Cheng Dong, Palida Abulize View Abstract ❯

Knockdown of AQP1 inhibits growth and invasion of human ovarian cancer cells Yanli Wang, Yanyan Fan, Chunhua Zheng, Xiaomeng Zhang View Abstract ❯

Genome-wide DNA methylation analysis in permanent atrial fibrillation Guochang Zhao, Jian Zhou, Jie Gao, Yan Liu, Song Gu, Xitao Zhang, Pixiong Su View Abstract ❯

Hypoxia suppresses osteogenesis of bone mesenchymal stem cells via the extracellular signal‑regulated 1/2 and p38‑mitogen activated protein kinase signaling pathways Peng Zhang, Nayoung Ha, Qinggang Dai, Siru Zhou, Chuangqi Yu, Lingyong Jiang View Abstract ❯

Polaprezinc inhibits liver fibrosis and proliferation in hepatocellular carcinoma Jun Ye, Zhengsen Zhang, Liang Zhu, Minfang Lu, Yan Li, Jingjing Zhou, Xinliang Lu, Qin Du View Abstract ❯

Identification of a novel FOXL2 mutation in a single family with both types of blepharophimosis‑-ptosis-epicanthus inversus syndrome Lin Yang, Tuo Li, Yiqiao Xing View Abstract ❯

Polysaccharide purified from Lycium barbarum protects differentiated PC12 cells against L‑Glu‑induced toxicity via the mitochondria‑associated pathway Ling Kou, Mingzhao Du, Chaopu Zhang, Zhiyin Dai, Xuan Li, Baohai Zhang, Xinyu Hu View Abstract ❯

Human urine-derived stem cells contribute to the repair of ischemic acute kidney injury in rats Shou‑Fu Tian, Zhen‑Zhen Jiang, Yu‑Mei Liu, Xin Niu, Bin Hu, Shang‑Chun Guo, Nian‑Song Wang, Yang Wang View Abstract ❯

Toll‑like receptor 4 is expressed and functional in late endothelial progenitor cells Min Yu, Cantian Wang, Guoning Zeng, Lihong Zhou, Tingting Chen, Xuerui Tan, Yanping Wang View Abstract ❯

Effect of Scutellarin inhibits collagen‑induced arthritis through TLR4/NF‑κB‑mediated inflammation Laibo Zhang, Shui Sun, Wei Li, Wei Zhang, Xianquan Wang, Shang-You Yang View Abstract ❯

Cysteine-rich 61-associated gene expression profile alterations in human glioma cells Rui Wang, Bo Wei, Jun Wei, Yu Tian, Chao Du View Abstract ❯

miR-491-3p suppresses the growth and invasion of osteosarcoma cells by targeting TSPAN1 Junhu Duan, Jiangtao Liu, Yin Liu, Bin Huang, Longhua Rao View Abstract ❯

Expression of microRNA‑222 in serum of patients with Alzheimer's disease Qinghong Zeng, Linqing Zou, Li Qian, Fang Zhou, Hongxia Nie, Shanhua Yu, Jiandong Jiang, Aixia Zhuang, Chuanqi Wang, Haojiang Zhang View Abstract ❯

Chinese herb extract improves liver steatosis by promoting the expression of high molecular weight adiponectin in NAFLD rats Xudong Liu, Wangxia Tong, Xiaofang Zhao, Hongxing Zhang, Yanfang Tang, Xin Deng View Abstract ❯

Long noncoding RNA colon cancer associated transcript‑1 promotes the proliferation, migration and invasion of cervical cancer Ligang Jia, Yuan Zhang, Fei Tian, Zhaoping Chu, Hong Xin View Abstract ❯

XB130 enhances invasion and migration of human colorectal cancer cells by promoting epithelial‑mesenchymal transition Jiancheng Shen, Chang'e Jin, Yonglin Liu, Heping Rao, Jinrong Liu, Jie Li View Abstract ❯

Identification of mutations in EXT1 and EXT2 genes in six Chinese families with multiple osteochondromas Yang Xu, Qinglin Kang, Zhenlin Zhang View Abstract ❯

Inhibitory effect of D3 dopamine receptors on neuropeptide Y‑induced migration in vascular smooth muscle cells Xue‑Wei Xia, Yong‑Qiao Zhou, Hao Luo, Chunyu Zeng View Abstract ❯

Inhibitory effect of curcumin in human endometriosis endometrial cells via downregulation of vascular endothelial growth factor Hong Cao, Yu‑Xi Wei, Qi Zhou, Ying Zhang, Xiao‑Peng Guo, Jun Zhang View Abstract ❯

Antimicrobial cathelicidin peptide LL‑37 induces NET formation and suppresses the inflammatory response in a mouse septic model Hiroshi Hosoda, Kaho Nakamura, Zhongshuang Hu, Hiroshi Tamura, Johannes Reich, Kyoko Kuwahara‑Arai, Toshiaki Iba, Yoko Tabe, Isao Nagaoaka View Abstract ❯

Ginkgolide B promotes cell growth in endothelial progenitor cells through miR-126 and the Akt signaling pathway Jing Chang, Xin Xue, Chunli Song, Bin Liu, Lihua Gao View Abstract ❯

Mda‑7/IL‑24 induces the differentiation of B cell lymphoma via activation of the P38 mitogen activated protein kinase signaling pathway Ming Ma, Xingxiao Yang, Lianmei Zhao, Lihua Liu, Cong Zhang, Xuexiao Wang, Baoen Shan View Abstract ❯

Expression of pro-inflammatory cytokines in the auditory cortex of rats with salicylate-induced tinnitus Xiang‑Hong Chen, Li‑Li Zheng View Abstract ❯

Transcriptional regulation and influence on replication of the human cytomegalovirus UL138 1.4 kb transcript Liying Han, Yanping Ma, Zhongyang Liu, Chang Liu, Ying Lu, Ying Qi, Yujing Huang, Zhengrong Sun, Qiang Ruan View Abstract ❯

Identification of key mRNAs and microRNAs in the pathogenesis and progression of osteoarthritis using microarray analysis Hua Li, Bing Bai, Jingrui Wang, Zanmei Xu, Saiying Yan, Guobin Liu View Abstract ❯

microRNA-20b contributes to high glucose-induced podocyte apoptosis by targeting SIRT7 Xiaojing Wang, Bo Lin, Lin Nie, Ping Li View Abstract ❯

Dopamine and serotonin contribute to Paecilomyces hepiali against chronic unpredictable mild stress induced depressive behavior in Sprague Dawley rats Juan Wang, Yange Liu, Lanzhou Li, Yidi Qi, Yuanzhu Zhang, Longtu Li, Lirong Teng, Di Wang View Abstract ❯

Thy-1 stimulation of mouse T cells induces a delayed T cell receptor-like signal that results in Ca2+‑independent cytotoxicity Suzanne Furlong, Melanie R. Power Coombs, David W. Hoskin View Abstract ❯

FcγRIIb attenuates TLR4‑mediated NF‑κB signaling in B cells Li Qian, Wenyan Chen, Shaoqing Wang, Yang Liu, Xiaoqin Jia, Yi Fu, Weijuan Gong, Fang Tian View Abstract ❯

Ca2+/Mg2+ homeostasis‑related TRPM7 channel mediates chondrocyte hypertrophy via regulation of the PI3K‑Akt signaling pathway Daigang Lu, Jining Qu, Liang Sun, Qiang Li, Hua Ling, Na Yang, Teng Ma, Qian Wang, Ming Li, Kun Zhang, Zhong Li View Abstract ❯

MicroRNA‑320a inhibition decreases insulin‑induced KGN cell proliferation and apoptosis by targeting PCGF1 Lei Yang, Yan Li, Xiaojing Wang, Yuling Liu, Lingzhu Yang View Abstract ❯

Overexpression of microRNA-448 inhibits osteosarcoma cell proliferation and invasion through targeting of astrocyte elevated gene-1 Weibo Jiang, Shu Wang, Yang Sun, Ying Jiang, Tao Yu, Jincheng Wang View Abstract ❯

Direct and indirect gene diagnosis of hemophilia A pedigrees in the Chinese population Ying Cao, Luxi Shen, Rong Huang, Lingcong Yang, Zhuanyun Du, Hua Ma, Tianjin Zheng, Haihua Gu, Hongzhi Li View Abstract ❯

Type II cGMP‑dependent protein kinase inhibits the migration, invasion and proliferation of several types of human cancer cells Min Wu, Yan Wu, Hai Qian, Yan Tao, Ji Pang, Ying Wang, Yongchang Chen View Abstract ❯

[Corrigendum] Death receptor 5 expression is inversely correlated with prostate cancer progression Angeles Hernandez‑Cueto, Daniel Hernandez‑Cueto, Gabriela Antonio‑Andres, Marisela Mendoza‑Marin, Carlos Jimenez‑Gutierrez, Ana Lilia Sandoval‑Mejia, Rosario Mora‑Campos, Cesar Gonzalez‑Bonilla, Mario I. Vega, Benjamin Bonavida, Sara Huerta‑Yepez View Abstract ❯

5-7 October, 2017, Metropolitan Hotel, Athens, Greece 22nd World Congress on Advances in Oncology & 20th International Symposium on Molecular Medicine 3-4 October 2017, Pre-Congress Workshop: 'Next-Generation Sequencing – Library construction and quality control'

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Scholar : These new articles for Voice and Speech Review are available online

The online platform for Taylor & Francis Online content New for Voice and Speech Review and online now on Taylor & Francis Online: Forum Carol Pendergrast: my journey to now Carol Pendergrast Pages: 1-4 | DOI: 10.1080/23268263.2017.1370837 Original Articles The utilization of non-classical approaches to teaching musical theatre repertoire to the undergraduate soprano voice major Jenna Lee Moore Pages: 1-10 | DOI: 10.1080/23268263.2017.1378473 To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Asian Geographer are available online

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The online platform for Taylor & Francis Online content New for Asian Geographer and online now on Taylor & Francis Online: Original Articles Summer climate implications of tree-ring latewood width: a case study of Tsuga longibracteata in South China Yesi Zhao , Jiangfeng Shi , Shiyuan Shi , Bowen Wang & Jian Yu Pages: 1-16 | DOI: 10.1080/10225706.2017.1377623 Find out more about the issues and challenges in Governing Asia. This collection includes free access papers on security challenges, the Abe and Modi administration, reflections on the Chinese Governance and more. Browse today! To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Annals of GIS are available online

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The online platform for Taylor & Francis Online content New for Annals of GIS and online now on Taylor & Francis Online: Original Articles Study on the construction of historical toponymic information management system for Essence of the Geographical Content of the History Books Longyu Liu & Di Hu Pages: 1-11 | DOI: 10.1080/19475683.2017.1368707 Browse papers on image & data fusion, GIS, LiDAR & more in the International Journal of Image and Data Fusion's exclusive Editor's Choice collection. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Journal of the Institute of Conservation are available online

The online platform for Taylor & Francis Online content New for Journal of the Institute of Conservation and online now on Taylor & Francis Online: Book Review Polychrome Sculpture: Meaning, Form, Conservation Lucy Wrapson Pages: 1-2 | DOI: 10.1080/19455224.2017.1371424 Colour Change in Paintings Christine Slottved Kimbriel Pages: 1-3 | DOI: 10.1080/19455224.2017.1360546 The Strasbourg Manuscript: A Medieval Tradition of Artists' Recipe Collections (1400–1570) Richard Gameson Pages: 1-2 | DOI: 10.1080/19455224.2017.1360547 To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Journal of Clinical and Experimental Neuropsychology are available online

The online platform for Taylor & Francis Online content New for Journal of Clinical and Experimental Neuropsychology and online now on Taylor & Francis Online: Original Articles Cognitive performance in transient global hypoxic brain injury due to moderate drowning Mariana Penteado Nucci , Katerina Lukasova, Gilson Vieira , João Ricardo Sato & Edson Amaro Júnior Pages: 1-11 | DOI: 10.1080/13803395.2017.1371674 Routledge Psychology 2017 sponsor of BPS #PsychCrunch podcasts. Access 25 journal articles: http://bit.ly/psychcrunch2017 To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Critical Inquiry in Language Studies are available online

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The online platform for Taylor & Francis Online content New for Critical Inquiry in Language Studies and online now on Taylor & Francis Online: Book Review Names and naming: People, places, perceptions and power, edited by G. Puzey and L. Kostanski Tonawanda, New York, Multilingual Matters, 2015, vii + 258 pp., ISBN 978-1-78309-490-5 (pbk). Heather Roach Pages: 1-3 | DOI: 10.1080/15427587.2017.1372966 To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Crystallography Reviews are available online

The online platform for Taylor & Francis Online content New for Crystallography Reviews and online now on Taylor & Francis Online: Reviews Symmetry in art and architecture of the Western Islamic world A. Thalal, Y. Aboufadil, M. A. Elidrissi Raghni, A. Jali, A. Oueriagli & K. Ait Rai Pages: 1-29 | DOI: 10.1080/0889311X.2017.1343306 Browse papers on image & data fusion, GIS, LiDAR & more in the International Journal of Image and Data Fusion's exclusive Editor's Choice collection. To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : These new articles for Research in Dance Education are available online

The online platform for Taylor & Francis Online content New for Research in Dance Education and online now on Taylor & Francis Online: Original Articles Unfurling the wings of flight: clarifying 'the what' and 'the why' of mental imagery use in dance | Vicky J. Fisher Pages: 1-21 | DOI: 10.1080/14647893.2017.1369508 To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : Journal for Cultural Research, Volume 21, Issue 3, September 2017 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content Journal for Cultural Research, Volume 21, Issue 3, September 2017 is now available online on Taylor & Francis Online. This new issue contains the following articles: Articles The sampling continuum: musical aesthetics and ethics in the age of digital production Adam Behr, Keith Negus & John Street Pages: 223-240 | DOI: 10.1080/14797585.2017.1338277 Derrida and messianic subjectivity: a hauntology of revealability Jacob W. Glazier Pages: 241-256 | DOI: 10.1080/14797585.2017.1338600 'Life is a state of mind' – on fiction, society and Trump Bülent Diken & Carsten Bagge Laustsen Pages: 257-267 | DOI: 10.1080/14797585.2017.1343027 'The letting go': the horror of being orphaned in Nicolas Winding Refn's cinema Mark Featherstone Pages: 268-285 | DOI: 10.1080/14797585.2017.1369686 The obsession with perfect health Ivan Illich & Translated by Antonio Cerella Pages: 286-291 | DOI: 10.1080/14797585.2016.1272824 To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : Arts & Health, Volume 9, Issue 3, October 2017 is now available online on Taylor & Francis Online

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The online platform for Taylor & Francis Online content Arts & Health, Volume 9, Issue 3, October 2017 is now available online on Taylor & Francis Online. This new issue contains the following articles: Research Articles Women's experiences of change through art therapy Gärd Marie-Louise Holmqvist, Henrika Jormfeldt, Ingrid Larsson & Cristina Lundqvist Persson Pages: 199-212 | DOI: 10.1080/17533015.2016.1225780 A randomized feasibility study on the effects of music therapy in the form of patient-preferred live music on mood and pain in patients on a cardiovascular unit Eric Walter Selle & Michael Joseph Silverman Pages: 213-223 | DOI: 10.1080/17533015.2017.1334678 The "lived" experience of Playback Theatre practitioners in post-war Sri Lanka: naivety, altruism, reciprocal caring, and psychological growth Lynne McCormack & Evelyn Henry Pages: 224-237 | DOI: 10.1080/17533015.2016.1262879 Evaluation of the impact on audiences of Inside Out of Mind, research-based theatre for dementia carers Justine Schneider Pages: 238-250 | DOI: 10.1080/17533015.2016.1251475 Art processes: a research tool for acquired brain injury and residential design Dianne Smith , Courtney J. Wright , Ali Lakhani & Heidi Zeeman Pages: 251-268 | DOI: 10.1080/17533015.2017.1354899 Therapeutic theatre: an experience from a mental health clinic in Yaoundé-Cameroon Paul Animbom Ngong Pages: 269-278 | DOI: 10.1080/17533015.2017.1296007 Editorial Board Editorial Board Pages: (ebi)-(ebi) | DOI: 10.1080/17533015.2017.1368201 Journal of Gay & Lesbian Social Services FREE ACCESS to the TOP 2016 Volume Year Articles. Find out more To update which email alerts you receive, manage your alerts within the My Account area. You can also unsubscribe from this alert with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Food safety aspects of primary environmental contaminants in the edible tissues of roe deer ( Capreolus capreolus )

Abstract

The muscle, liver, kidney and fat samples of 20 roe deer of both sexes originating from a hunting area in central Hungary were investigated for the presence of heavy metals such as As, Cd, Hg and Pb, and their contents were evaluated for possible health risk to consumers. Both As and Hg were found at a level below the limit of detection (< 0.5 mg/kg wet weight) in all samples. The median of the measured Cd concentrations was significantly higher in both the kidney and the liver (p = 0.0011) of bucks than of does. In bucks, Cd levels exceeded the respective maximum limits laid down in the European legislation in four kidney and three muscle samples, whereas in does, the measured concentrations were below the respective limits in all samples. The detected amounts of Pb exceeded the maximum limits in the kidney of one buck and eight does, in the liver of two bucks and six does, in the muscle of six bucks and nine does, whereas in all fat tissues of both bucks and does. The concentration of Pb (p = 0.02) was significantly greater in the kidney of does compared to roebucks. Based on data obtained from the present study, the consumption of organs and tissues of the investigated roe deer could be objectionable from food-toxicological point of view and may pose risk to the high consumers of wild game due to their cadmium and lead contents.

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Pediatric Patient With Chronic Generalized Blisters: Challenge

No abstract available

http://ift.tt/2jJnbSk

Hemosiderotic Juvenile Xanthogranuloma

Abstract: Juvenile xanthogranuloma is a non-Langerhans cell lesion mostly limited to the skin but occasionally presenting in extracutaneous locations or associated with systemic conditions. Lesions need to be distinguished mainly from dermatofibroma, xanthoma, Langerhans cell histiocytosis, or reticulohistiocytoma. Herein, we present a hemosiderotic variant of juvenile xanthogranuloma in a 12-year-old girl, which we have not found described in literature. The lesion presented at the back of the scalp as a slowly growing yellowish polypoid lesion showing occasional bleeding. The histopathological examination demonstrated a cellular infiltrate expanding the dermis, with a Grenz zone and with no remarkable changes in the overlying epidermis. The papule was made of mononucleated macrophages, many of which were xanthomatous. There were some Touton giant cells. The lesion was intermingled with a mild inflammatory infiltrate comprising lymphocytes, plasma cells, neutrophils, and some eosinophils. Many of the macrophages contained abundant cytoplasmic deposits of iron. The macrophages expressed CD68 and CD163, whereas they failed to express S100 protein, CD1a, and Langerin.

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p53 Is a Helpful Marker in Distinguishing Langerhans Cell Histiocytosis From Langerhans Cell Hyperplasia

Abstract: Langerhans cell histiocytosis (LCH) is a proliferative disorder of Langerhans cells that can be challenging to distinguish histologically from Langerhans cell (LC) hyperplasia, seen in a variety of inflammatory dermatoses. Lesional cells in both entities demonstrate positive staining for CD1a and S100. Previous studies have demonstrated positive staining of fascin, CD31, and p53 in cases of LCH, but currently, no studies have compared the staining profiles of these markers between LCH and LC hyperplasia. The authors compared immunohistochemical staining profiles of LCH (n = 15) and various inflammatory dermatoses with LC hyperplasia (n = 15) using fascin, CD31, and p53. Fascin, CD31, and p53 were graded as a percentage of CD1a staining cells in the epidermis and dermis of each specimen. Fascin showed no significant differences in staining between the 2 entities. CD31 was positive in the dermal infiltrate in 40% of cases of LCH and negative in all cases of LC hyperplasia. p53 was positive in the epidermal infiltrate in 50% of cases of LCH, and positive in the dermal infiltrate in 93% of cases of LCH, whereas negative in all cases of LC hyperplasia. Fascin was not a helpful marker in distinguishing LCH from LC hyperplasia. CD31, if positive in the dermal infiltrate, is suggestive of a diagnosis of LCH, but exhibits a relatively low sensitivity for this purpose. p53 proved to be a helpful and accurate diagnostic immunohistochemical stain when distinguishing between LCH and LC hyperplasia.

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Pediatric Patient With Chronic Generalized Blisters: Answer

No abstract available

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c-CBL E3 Ubiquitin Ligase Expression Increases Across the Spectrum of Benign and Malignant T-Cell Skin Diseases

Abstract: Prolonged survival of lesional T cells plays a central role in the pathogenesis of T-cell-mediated dermatoses. We have recently shown that the ubiquitin ligase c-CBL is highly expressed in cutaneous T-cell lymphoma (CTCL) and that its knockdown increases activation-induced cell death, a key pathway for T-cell apoptosis. Here, we extend our work on c-CBL expression in malignant T cells to their nonneoplastic counterparts in benign inflammatory dermatoses. Immunohistochemical staining with anti-c-CBL antibody was performed on lesional biopsies from a total of 65 patients with atopic dermatitis, allergic contact dermatitis, pityriasis rosea, psoriasis vulgaris, lichen planus, mycosis fungoides (MF)/Sézary syndrome (SS) as well as on tonsil tissue from 5 individuals and on 5 human CTCL cell lines. Protein levels were measured in situ using multispectral image analysis, a quantitative method that is ×5 more sensitive than standard immunohistology for antigen detection. There was a significant (P

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Galectin-3 Expression in Benign and Malignant Skin Diseases With Epidermal Hyperplasia

Abstract: Galectin-3 has been suggested relative to tumor genesis, progression, and metastasis in basal cell carcinoma and squamous cell carcinoma that are the most common skin cancers characterized by malignant epidermal proliferation. In this study, we evaluated galectin-3 expression in seborrheic keratosis, keratoacanthoma, and infectious diseases including verruca vulgaris, condyloma acuminatum, and chromoblastomycosis that are pathologically featured by benign epidermal proliferation. Galectin-3 expression was shown by immunohistochemical staining and quantified using the Image Pro Plus V6.0. We found that galectin-3 distributed evenly in normal skin around the body decreased significantly in all selected diseases compared with healthy controls, but it was comparable among each disease. These findings imply that galectin-3 do not differentiate between benign and malignant proliferation of keratinocytes.

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Sox10-Positive Cells Within Scars: A Potential Diagnostic Pitfall

No abstract available

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Toll-Like Receptor 7 Staining in Malignant Epithelial Tumors

Background: As important players of the innate immune system, Toll-like receptors (TLRs) and their role for tumorigenesis have been in the focus of research. In particular TLR7 is an interesting candidate, as TLR7 agonists are broadly used for the treatment of cutaneous tumors. However, data addressing the baseline expression of TLR7 in both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) on the protein level are lacking, while on the genomic level significantly elevated expression of TLR7 in SCC but not in BCC has been demonstrated. Aim: Our aim was to characterize the immunohistochemical staining pattern of TLR7 in SCC and BCC. Besides, we aimed to clarify if, in case of different TLR7 expression between SCC and BCC, TLR7 expression would help to define basosquamous carcinoma (BSC), a tumor entity sharing characteristics of both SCC and BCC. Methods: We examined histopathological samples from 23 BCC, 4 BSC, and 24 SCC and characterized the expression of TLR7 by immunohistochemistry and immunofluorescence. Results: We found that TLR7 was not expressed by the tumor tissue of SCC, BCC, and BSC, but by inflammatory cells located within the tumoral and/or peritumoral tissue. Whereas the overall expression of TLR7 did not differ between BCC and SCC (30.4% vs. 45.8%, respectively), we found that within the group of SCC, the well-differentiated SCC showed strong tumoral and/or peritumoral immunocellular TLR7 reactivity in contrast to the poorly differentiated SCC (73.33% vs. 11.1%, respectively). Besides, immunofluorescence double staining revealed the expression of TLR7 in immune cells closely interacting with T cells and natural killer cells. Conclusions: In contrast to genomic data, we did not find a general difference between baseline TLR7 expression of SCC and BCC on the protein level. Nevertheless, the expression of TLR7 by the inflammatory infiltrate associated with SCC may correlate with the degree of differentiation of SCC possibly indicating better outcome.

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Activation of PKCα and PI3K Kinases in Hypertrophic and Nodular Port Wine Stain Lesions

Abstract: Port wine stain (PWS) is a congenital, progressive vascular malformation. Many patients with PWS develop hypertrophy and discrete nodularity during their adult life, but the mechanism(s) remain incompletely understood. In this study, we attempted to investigate activation status of PKCα, PI3K, PDPK1 and PLC-γ and protein levels of PP2A and DAG to explore their potential roles in the formation of hypertrophic and nodular PWS lesions. We found phosphorylated levels of PKCα, PI3K, PDPK1, and PLC-γ and protein levels of PP2A and DAG showed moderate increases in the endothelial cells of hypertrophic PWS as compared to the adjacent normal skin. These increases extended throughout the entire stroma of blood vessels in PWS nodules. Many proliferating cells, such as fibroblasts, also showed strong activation of PKCα, PI3K, PDPK1 and PLC-γ and upregulations of PP2A and DAG in nodular PWS lesions. Our data showed that there is aberrant activation of PKCα, PI3K, PDPK1 and PLC-γ and upregulation of PP2A and DAG mainly in endothelial cells in hypertrophic PWS areas, but presenting in the entire vasculatures and surrounding fibroblasts in PWS nodules. Our data suggest that both PKCα and PI3K signaling pathways contribute to the development of hypertrophy and nodularity in adult PWS.

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Cutaneous Rosai–Dorfman Disease With Linear Lesions and Monoclonal Gammopathy

Abstract: Cutaneous Rosai–Dorfman disease (CRDD), a benign histiocytosis of unknown etiology, typically presents as a solitary or clusters of lesions. Although the histopathology is fairly distinctive, the laboratory abnormalities are not; past reports note elevated erythrocyte sedimentation rate, anemia, and polyclonal hyperglobulinemia. We describe a 61-year-old African American diabetic gentleman who presented with nodules in a linear distribution on the flank. Histopathologic examination of a biopsied nodule revealed a pandermal sheet-like infiltrate of plasma cells and histiocytes, some demonstrating elastophagocytosis and emperipolesis. The lesional histiocytes were S100 and CD68 positive and CD1a negative—findings consistent with a diagnosis of CRDD. Additional laboratory work-up performed 12 weeks after the biopsy was taken revealed an elevated serum κ light chain concentration of 37.26 mg/L (reference range: 3.30–19.40 mg/L), which correlated with an M-protein spike identified as IgG κ proteins per serum protein electrophoresis. Given the difficulty in excising a large area and preexisting diabetes, a course of low-dose methotrexate was selected for therapy with a recommendation of close follow-up for the monoclonal gammopathy. To the best of our knowledge, this is the first report of CRDD associated with a linear distribution of lesions and serum protein electrophoresis–confirmed monoclonal gammopathy.

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The Histopathology of Urticaria Revisited—Clinical Pathological Study

Background: The classic histopathological findings of urticaria include dermal edema and a sparse perivascular infiltrate of neutrophils, eosinophils, macrophages, and lymphocytes. However, this pattern is inconsistently described. Objective: To describe the histological and immunofluorescence characteristics of urticaria and to identify distinctive patterns. Methods: A retrospective study was performed in which the medical files and biopsy specimens of 58 patients with acute and chronic classical urticaria were reviewed. Pathological parameters were quantified. Results: We recognized 2 distinctive patterns of urticaria: lymphocyte and neutrophil predominant; the former was characterized by a perivascular location, whereas the latter was associated with an interstitial location and a denser infiltrate. Mast cells were relatively sparse, better demonstrated with special stains. Tryptase stain demonstrated more mast cells than Giemsa stain. Extravasated erythrocytes were present in 50% of the cases, but vasculitis was not observed. Conclusions: Histological findings in classical urticaria show a spectrum of findings from a sparse superficial perivascular to a deep perivascular and interstitial infiltrate. Distinctive groups based on the dominant cell type can be identified, accounting for the similarity to neutrophilic urticarial dermatosis. Lesions may have a purpuric appearance, but leukocytoclastic vasculitis is never present.

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Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type, With Spontaneous Regression After Biopsy

Abstract: Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT) represents approximately 20% of cutaneous B lymphomas with an intermediate prognosis. Spontaneous regression is uncommon; there are only 2 published cases. An 83-year-old woman presented 2 orange erythematous nodules on the back of her right leg with an elastic consistency, infiltrated, painful to the touch, and of an 8-month evolution. A histological examination revealed a dense cellular dermo-hypodermic infiltrate sparing the papillary dermis, composed of large cells with immunoblast and centroblast morphology and frequent mitosis. Immunohistochemical studies showed positivity for CD20, CD79, Bcl2, Bcl6, MUM1, Fox-P1, and IgM with Ki67 >95%. Rearrangement of heavy IgH chains was monoclonal. The extension study was negative, establishing a diagnosis of PCDLBCL-LT, T2aN0M0. Three months after biopsy, the patient's lesions regressed spontaneously. New biopsies were taken that revealed a mild diffused dermo-hypodermic cellular infiltrate compounded by small-sized T lymphocytes, with predominance of CD8. Despite its self-limited character, treatment with radiotherapy was done, remaining asymptomatic after 1 year follow-up. There are 2 published cases of PCDLBCL-LT with spontaneous regression. The cause of this unusual autoinvolutional phenomenon is unknown; it may be an immune response against tumor cells through a traumatic or infectious mechanism.

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Loss of Conventional Melanocytic Markers in Malignant Melanoma and Lymph Node Metastasis; an Uncommon but Dangerous Pitfall

Abstract: Although malignant melanomas exhibit a wide range of immunophenotypes, concurrent loss of all 3 conventional melanocytic markers (S-100, Melan-A, and HMB-45) is relatively rare. We report a case of primary malignant melanoma with lymph node metastasis, both exhibiting loss of immunoreactivity for conventional melanocytic markers, while aberrantly expressing epithelial antigenicity (pancytokeratin, CAM 5.2).

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Asymptomatic Facial Papules in a Pediatric Patient: Challenge

No abstract available

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Necrotizing Infundibular Crystalline Folliculitis (NICF) Induced by Anti-Tumoral Therapies: Report of 2 Cases

Abstract: Necrotizing Infundibular Crystalline Folliculitis (NICF) is rare entity of unknown pathogenesis presenting as follicular crystalline papules arising in seborrheic areas. We report 2 cases of NICF in patients under targeted therapy for metastatic adenocarcinoma. In one case, the lesions reappeared cyclically every 3 weeks after each injection and in the other case, lesions persisted until disruption of the continuous oral therapy. Punch-biopsies demonstrated folliculitis with a plugging crystalline material associated with either bacteria or yeast. These are the first descriptions of drug-induced NICF.

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Sporadic Trichoblastomas and Those Occurring in the Setting of Multiple Familial Trichoepithelioma/Brooke–Spiegler Syndrome Show No BAP1 Loss

No abstract available

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Plaque-Like Myofibroblastic Tumor: Report of 4 Cases

Abstract: Plaque-like myofibroblastic tumor of infancy was first characterized in 2007 by Clarke et al. In the first 2 cases described, large plaque-like tumors presented in the first 3 months of life exhibited microscopic features consistent with dermatofibroma but with immunohistochemical features of myofibroblastic lineage. In 2013, Marqueling et al reported 3 additional cases, 2 of which presented in early childhood, prompting the authors to recommend that the name of this condition be shortened to plaque-like myofibroblastic tumor. We present here 4 additional cases to better characterize clinical and histopathological features of this newly recognized entity. This benign lesion is of myofibroblastic lineage and demonstrates features consistent with multiple clustered dermatofibroma.

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Asymptomatic Facial Papules in a Pediatric Patient: Answer

No abstract available

http://ift.tt/2wG8FMd

Late Arterial Thrombosis after Microvascular Head and Neck Reconstruction due to Combined Factors of Pedicle Artery Loop and Submandibular Gland Swelling

Summary: Late arterial thrombosis of a free flap is rare and usually unsalvageable because it is hard to detect. We herein report 2 cases of arterial thrombosis of a free flap after microvascular head and neck reconstruction due to the combined factors of pedicle artery loop and compression by a swollen submandibular gland, the occurrence of thrombosis in both of which was > 72 hours after the operation. In case 1, the arterial thrombosis was undetectable, and it was too late for a successful take-back operation, so the flap was lost. However, we applied the lessons learned from case 1 and were able to detect the late arterial thrombosis of case 2 at an early stage; we subsequently salvaged the flap successfully. During the take-back operation in both cases, it was found that the submandibular gland became swollen and compressed the pedicle artery, which then became occluded due to a steep loop formation. Postoperative swelling of the submandibular gland can sometimes compress the vascular pedicle, and complete occlusion of the pedicle artery may occur when it is looped. Meticulous care concerning the geometry of the vascular pedicle is required to avoid such complications.

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Diffuse recurrent cutaneous melanoma of the scalp and neck successfully treated with volumetric modulated arc therapy and concurrent Ipilimumab

Publication date: Available online 19 September 2017
Source:Practical Radiation Oncology
Author(s): Ryan K Schmid, Amy Harker-Murray, Karen Niemczyk, Jared R Robbins




http://ift.tt/2wxmlhH

Comparative postnatal histomorphogenesis of the mandible in wild and laboratory mice

Publication date: Available online 18 September 2017
Source:Annals of Anatomy - Anatomischer Anzeiger
Author(s): Jessica Martínez-Vargas, Cayetana Martinez-Maza, Francesc Muñoz-Muñoz, Nuria Medarde, Hayat Lamrous, María José López-Fuster, Jorge Cubo, Jacint Ventura
The coordinated activity of bone cells (i.e., osteoblasts and osteoclasts) during ontogeny underlies observed changes in bone growth rates (recorded in bone histology and bone microstructure) and bone remodeling patterns explaining the ontogenetic variation in bone size and shape. Histological cross-sections of the mandible in the C57BL/6J inbred mouse strain were recently examined in order to analyze the bone microstructure, as well as the directions and rates of bone growth according to the patterns of fluorescent labeling, with the aim of description of the early postnatal histomorphogenesis of this skeletal structure. Here we use the same approach to characterize the histomorphogenesis of the mandible in wild specimens of Mus musculus domesticus, from the second to the eighth week of postnatal life, for the first time. In addition, we assess the degree of similarity in this biological process between the wild specimens examined and the C57BL/6J laboratory strain. Bone microstructure data show that Mus musculus domesticus and the C57BL/6J strain differ in the temporospatial pattern of histological maturation of the mandible, which particularly precludes the support of mandibular organization into the alveolar region and the ascending ramus modules at the histological level in Mus musculus domesticus. The patterns of fluorescent labeling reveal that the mandible of the wild mice exhibits temporospatial differences in the remodeling pattern, as well as higher growth rates particularly after weaning, compared to the laboratory mice. Since the two mouse groups were reared under the same conditions, the dissimilarities found suggest the existence of differences between the groups in the genetic regulation of bone remodeling, probably as a result of their different genetic backgrounds. Despite the usual suitability of inbred mouse strains as model organisms, inferences from them to natural populations regarding bone growth should be made with caution.



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Mitochondrial Metabolism: Yin and Yang for Tumor Progression

Publication date: October 2017
Source:Trends in Endocrinology & Metabolism, Volume 28, Issue 10
Author(s): Lorea Valcarcel-Jimenez, Edoardo Gaude, Veronica Torrano, Christian Frezza, Arkaitz Carracedo
Altered metabolism is a distinct feature of cancer cells. During transformation, the entire metabolic network is rewired to efficiently convert nutrients to biosynthetic precursors to sustain cancer cell growth and proliferation. Whilst the molecular underpinnings of this metabolic reprogramming have been described, its role in tumor progression is still under investigation. Importantly, the mitochondrion is a central actor in many of the metabolic processes that are altered in tumors. Yet, we have only begun to understand the dualities of mitochondrial function during cancer metastasis and therapy resistance. Paradoxically, mitochondrial metabolism can be both advantageous and detrimental to these processes, highlighting the need for a better understanding of the molecular and microenvironmental cues that define the role of this fascinating organelle. In this review article, we present an updated view on the different mitochondrial metabolic strategies adopted by cancer cells to overcome the many hurdles faced during tumor progression.



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Editorial Board and Contents

Publication date: October 2017
Source:Trends in Endocrinology & Metabolism, Volume 28, Issue 10





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DNA damage response inhibitors: mechanisms and potential applications in cancer therapy

Publication date: Available online 19 September 2017
Source:Cancer Treatment Reviews
Author(s): Laura Carrassa, Giovanna Damia
Over the last decade the unravelling of the molecular mechanisms of the DNA damage response pathways and of the genomic landscape of human tumors have paved the road to new therapeutic approaches in oncology. It is now clear that tumors harbour defects in different DNA damage response steps, mainly signalling and repair, rendering them more dependent on the remaining pathways. We here focus on the proteins ATM, ATR, CHK1 and WEE1, reviewing their roles in the DNA damage response and as targets in cancer therapy. In the last decade specific inhibitors of these proteins have been designed, and their potential antineoplastic activity has been explored both in monotherapy strategies against tumors with specific defects (synthetic lethality approach) and in combination with radiotherapy or chemotherapeutic or molecular targeted agents. The preclinical and clinical evidence of antitumor activity of these inhibitors emanating from these research efforts will be critically reviewed. Lastly, the potential therapeutic feasibility of combining together such inhibitors with the aim to target particular subsets of tumors will be also discussed. .



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Granuloma annulare can occur on a scar, mimicking sarcoidosis

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Oral administration of milk-derived phospholipids inhibits penetration of cutaneous nerve fibres into epidermis in a mouse model of acute dry skin

Summary

The density of intraepidermal nerve fibres has been shown to be higher in itchy dry skin than in healthy skin, suggesting that epidermal hyperinnervation is at least partly involved in peripheral itch sensitization. We investigated whether oral administration of milk-derived phospholipids (MPLs) would inhibit epidermal hyperinnervation in a mouse model of dry skin. We found that the number of intraepidermal nerve fibres was significantly lower in the MPL group than in the control group. Expression of nerve growth factor (NGF) levels in the epidermis was significantly decreased by oral administration of MPLs, whereas expression of semaphorin (Sema)3A, a nerve repulsion factor, was increased in the MPL group. These results suggest that dietary MPLs attenuate the penetration of nerve fibres into the epidermis by reducing epidermal NGF levels and increasing Sema3A level. Thus, dietary MPLs may have beneficial effects in the prevention and/or alleviation of dry skin-induced itch by reducing intraepidermal nerve fibre density.

http://ift.tt/2ycNNgR