Scholar : ΓΛΩΣΣΙΤΙΣ - νέα αποτελέσματα

Diagnosis of Orofacial Pain of Dental Origin

JK Jones - Diagnosis and Management of Head and Face Pain, 2018

… They can be infectious, inflammatory, or autoimmune in nature. Some examples are lichen
planus, benign mucous membrane pemphigoid, pemphigus vulgaris, monoliasis, herpetic
gingivostomatitis, benign migratory glossitis, and major aphthae …

[HTML] Allgemeine Krankheitslehre fur Physiotherapeuten (Physiotherapie Basics)(German Edition)

W Siems, A Bremer, J Przyklenk

Home; Add Document; Sign In; Register. Allgemeine Krankheitslehre fur
Physiotherapeuten (Physiotherapie Basics) (German Edition) …

 

Δημιουργία λίστας των ειδοποιήσεών μου

Ακύρωση ειδοποίησης

Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.

Scholar : ΑΠΟΚΑΤΑΣΤΑΣΗ - νέα αποτελέσμ

Πρώιμη Παρέμβαση σε παιδιά με οπτική αναπηρία

Ν Πεϊτζίκα - 2018

… Date Issued: 2018. Department: Πρόγραμμα Μεταπτυχιακών Σπουδών Ειδική Αγωγή,
Εκπαίδευση και Αποκατάσταση. Supervisor: Παπαδόπουλος, Κωνσταντίνος … Appears in
Collections: ΠΜΣ Ειδική Αγωγή, Εκπαίδευση και Αποκατάσταση (Μ). Files in This Item …

 

Δημιουργία λίστας των ειδοποιήσεών μου

Ακύρωση ειδοποίησης

Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.

Levels and gas-particle partitioning of hexabromocyclododecanes in the urban air of Dalian, China

Abstract

The concentrations of α-, β-, and γ-hexabromocyclododecane diastereomers (HBCDs) in gas phase and particulate phase of Dalian urban air, China, were monitored from September 2016 to August 2017 with high-volume active sampler. The total concentration of ∑HBCDs (gas phase + particulate phase) ranged from 15.47 to 43.57 pg m⁻³, with an average of 27.07 pg m⁻³, and 73.39–96.76% of the total HBCDs were found in the particulate phase. No matter in gas phase or in particulate phase, α-HBCD was the predominant component in all, and there was a good negative correlation between the relative contribution of α-HBCD to ∑HBCDs and that of γ-HBCD to ∑HBCDs. The average ratios of the air concentration of α-HBCD to γ-HBCD were comparable with those found in decorative polystyrene, which indicated that HBCDs in outdoor air of Dalian probably came from indoor air and ventilation air from inside of buildings coupled with the already present contamination in background air. There were clear seasonal differences in the HBCD concentrations. Spearman's rank correlation analysis between the concentrations of HBCDs with meteorological parameters was conducted. The exposure risk of HBCDs was evaluated, which illustrated that the estimated exposure of HBCDs via the outdoor air in Dalian was well below the reference doses (200 ng kg⁻¹ bw day⁻¹) derived by the US National Research Council.

https://ift.tt/2LOYtcZ

Adaptive coding in the human brain: Distinct object features are encoded by overlapping voxels in frontoparietal cortex

Publication date: Available online 25 July 2018

Source: Cortex

Author(s): Jade Jackson, Alexandra Woolgar

Abstract

Our ability to flexibly switch between different tasks is a key component of cognitive control. Non-human primate (NHP) studies (e.g. Freedman, Riesenhuber, Poggio, & Miller, 2001) have shown that prefrontal neurons are re-used across tasks, re-configuring their responses to code currently relevant information. In a similar vein, in the human brain, the "multiple demand" (MD) system is suggested to exert control by adjusting its responses, selectively processing information in line with our current goals (Duncan, 2010). However, whether the same or different resources (underlying neural populations) in the human brain are recruited to solve different tasks remains elusive. In the present study, we aimed to bridge the gap between the NHP and human literatures by examining human functional imaging data at an intermediate level of resolution: quantifying the extent to which single voxels contributed to multiple neural codes. Participants alternated between two tasks requiring the selection of feature information from two distinct sets of objects. We examined whether neural codes for the relevant stimulus features in the two different tasks depended on the same or different voxels. In line with the electrophysiological literature, MD voxels were more likely to contribute to multiple neural codes than we predicted based on permutation tests. Comparatively, in the visual system the neural codes depended on distinct sets of voxels. Our data emphasise the flexibility of the MD regions to re-configure their responses and adaptively code relevant information across different tasks.

https://ift.tt/2NLEf4f

Spatial working memory in Progressive Supranuclear Palsy

Publication date: Available online 25 July 2018

Source: Cortex

Author(s): Daniel T. Smith, Neil Archibald

Abstract

The neural and cognitive mechanisms of spatial working memory are tightly coupled with the systems that control eye-movements but the precise nature of this coupling is not well understood. In particular, there are very few neuropsychological studies that explicitly examine how deficits of oculomotor control affect visuospatial working memory. Here, we examined the link between spatial working memory and the oculomotor system in a sample of patients with PSP, a degenerative neurological disease characterised by defective vertical eye-movements but relatively preserved horizontal eye-movements. Consistent with the idea that the oculomotor system plays a critical role in spatial working memory performance, people with PSP had significantly shorter spatial spans when stimuli were presented along the vertical axis compared to the horizontal axis. This effect was not observed in age matched controls. We hypothesise that PSP disrupts a colliculo-parietal feedback loop that contributes to the maintenance of activation in a parietal priority map during the delay period. This result is the first direct neuropsychological evidence for an association between oculomotor function and spatial working memory and is broadly consistent with idea that rehearsal in visuospatial working memory is mediated by an 'oculomotor loop', as proposed by Baddeley (1986). We conclude that optimal spatial working memory performance depends on an intact oculomotor system.

https://ift.tt/2uRc0Kp

Simultaneous multi-parametric mapping of total sodium concentration, T1, T2 and ADC at 7 T using a multi-contrast unbalanced SSFP

Publication date: Available online 25 July 2018

Source: Magnetic Resonance Imaging

Author(s): Lisa Leroi, Arthur Coste, Ludovic de Rochefort, Mathieu D. Santin, Romain Valabregue, Franck Mauconduit, Eric Giacomini, Michel Luong, Edouard Chazel, Julien Valette, Denis Le Bihan, Cyril Poupon, Fawzi Boumezbeur, Cécile Rabrait-Lerman, Alexandre Vignaud

Abstract

Purpose

Quantifying multiple NMR properties of sodium could be of benefit to assess changes in cellular viability in biological tissues. A proof of concept of Quantitative Imaging using Configuration States (QuICS) based on a SSFP sequence with multiple contrasts was implemented to extract simultaneously 3D maps of applied flip angle (FA), total sodium concentration, T₁, T₂, and Apparent Diffusion Coefficient (ADC).

Methods

A 3D Cartesian Gradient Recalled Echo (GRE) sequence was used to acquire 11 non-balanced SSFP contrasts at a 6 × 6 × 6 mm³ isotropic resolution with carefully-chosen gradient spoiling area, RF amplitude and phase cycling, with TR/TE = 20/3.2 ms and 25 averages, leading to a total acquisition time of 1 h 18 min. A least-squares fit between the measured and the analytical complex signals was performed to extract quantitative maps from a mono-exponential model. Multiple sodium phantoms with different compositions were studied to validate the ability of the method to measure sodium NMR properties in various conditions.

Results

Flip angle maps were retrieved. Relaxation times, ADC and sodium concentrations were estimated with controlled precision below 15%, and were in accordance with measurements from established methods and literature.

Conclusion

The results illustrate the ability to retrieve sodium NMR properties maps, which is a first step toward the estimation of FA, T₁, T₂, concentration and ADC of ²³Na for clinical research. With further optimization of the acquired QuICS contrasts, scan time could be reduced to be suitable with in vivo applications.

https://ift.tt/2LPP8l2

Melanoma risk after in vitro fertilization: A review of the literature

Publication date: Available online 25 July 2018

Source: Journal of the American Academy of Dermatology

Author(s): Juliana Berk-Krauss, Amy Kalowitz Bieber, Maressa C. Criscito, Jane M. Grant-Kels, Marcia S. Driscoll, Martin Keltz, Miriam Keltz Pomeranz, Kathryn J. Martires, Tracey N. Liebman, Jennifer A. Stein

Abstract

Background

The role of female sex hormones in the pathogenesis of malignant melanoma (MM) remains controversial. While melanocytes appear to be hormonally responsive, the effect of estrogen on MM cells is less clear. Available clinical data does not consistently demonstrate that increased endogenous hormones from pregnancy, or increased exogenous hormones from oral contraceptive pills and hormone replacement, impact MM prevalence and outcome.

Objective

We sought to examine potential associations between in vitro fertilization (IVF) and melanoma.

Methods

A literature review was conducted. Primary outcomes were reported as associations between IVF and melanoma risk, as compared to the general population. Secondary outcomes included associations stratified by type of IVF regimen and subgroup, such as parous versus nulliparous patients.

Results

Eleven studies met our inclusion criteria. Five studies found no increased risk of MM among IVF users as compared to the general population. Two studies found an increase in MM in clomiphene users. Four studies found an increase in MM among patients who were gravid or parous either before or after IVF.

Conclusions

The reviewed studies do not reveal consistent patterns of association between IVF and MM among all infertile women. However, the data indicates that there may be an increased risk of MM in ever-parous patients treated with IVF. High-quality studies, which include a large number of MM cases and control for well-established MM risk factors, are needed to adequately assess the relationship between IVF and MM, particularly among ever-parous women.

https://ift.tt/2Aaq6Ma

Practical Needle Driver Cleaning Technique When Using Fast Absorbing Plain Gut Sutures for Facial Defect Repair

Publication date: Available online 25 July 2018

Source: Journal of the American Academy of Dermatology

Author(s): Romi Bloom, Daihung Do

https://ift.tt/2mIlRxG

The density and distribution of acral melanocytic nevi and acral melanomas on the plantar foot

Publication date: Available online 25 July 2018

Source: Journal of the American Academy of Dermatology

Author(s): Shirin Ghanavatian, Collin M. Costello, Matthew R. Buras, Helen JL. Cumsky, Mark R. Pittelkow, David L. Swanson, Aaron R. Mangold

https://ift.tt/2A6Pxhw

Preservation of Sebaceous Glands and PPARγ Expression in Central Centrifugal Cicatricial Alopecia

Publication date: Available online 25 July 2018

Source: Journal of the American Academy of Dermatology

Author(s): Yemisi Dina, Walaa Borhan, Gulsun Erdag, Ginette A. Okoye, Rajni Sharma, Powell Perng, Crystal Aguh

https://ift.tt/2OiaMQA

Bromate removal from aqueous solution with novel flower-like Mg-Al-layered double hydroxides

Abstract

A series of flower-like Mg-Al-layered double hydroxides (FHMA) with four Mg/Al ratios were successfully prepared via a simple method which put the mixed solution of magnesium and aluminum in the mixed solution of water and ethylene glycol (EG). After calcination under 600 °C, the calcination products (CFHMA) were used to adsorb bromate anionic from aqueous solution. The FHMA, CFHMA, and reconstructed CFHMA were characterized by FT-IR, XRD spectra, TG/DTA, N₂ adsorption-desorption isotherm, and SEM. It was found that FHMA had the flower-like morphology when Mg/Al ratio was 2 and 3. Moreover, FHMA lost the layered structures during calcination under 600 °C, but the disappeared structures were reconstructed after adsorption of bromate anionic, which was attributed to the "reformation effect" of FHMA with bromate as an interlayer anion. A series of adsorption studies were performed and the mechanism and reactivity of CFHMA were discussed including the effect of different kind of equilibration conditions, such as initial bromate anionic concentration, adsorbent dosage, contact time, initial solution pH, and co-existing anions. The results of adsorption displayed that the most suitable calcination temperature of FHMA is 600 °C, and the best ratio of Mg/Al is 2:1 to remove bromate anionic pollutant from water. The equilibrium adsorption data of CFHMA revealed a good compliance with the Langmuir model and the experimental data of CFHMA fitted well to the pseudo-second-order kinetic model. The calcination product of FHMA was a decent adsorbent of bromate anionic pollutant.

https://ift.tt/2JRpcnm

Scholar : These new articles for International Journal of Rail Transportation are available online

The online platform for Taylor & Francis Online content New for International Journal of Rail Transportation and online now on Taylor & Francis Online: Original Articles A systematic approach for streamlined head form design and evaluation of Chinese high-speed train Ze-Rui Xiang, Jin-Yi Zhi, Jun-Hui Huang, Hong-Jun Kang, Tian Li, Peng-Fei Gao & Fang Li Pages: 1-23 | DOI: 10.1080/23248378.2018.1501776 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : Australian Journal of Maritime & Ocean Affairs, Volume 10, Issue 3, September 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content Australian Journal of Maritime & Ocean Affairs, Volume 10, Issue 3, September 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Articles Changing contours of India's Ocean strategy, 2004–2015 Chinmoyee Das Pages: 153-167 | DOI: 10.1080/18366503.2018.1465253 Risk management on offshore vessels: training, expectations and reality Waldemar Daszuta & Samrat Ghosh Pages: 168-181 | DOI: 10.1080/18366503.2018.1486065 The twenty year anniversary of Australia's Oceans Policy: achievements, challenges and lessons for the future Joanna Vince Pages: 182-194 | DOI: 10.1080/18366503.2018.1490882 Commentary Looking to the long-term for management of tropical tunas? An assessment of special requirements arguments at WCPFC14 Angela Abolhassani Pages: 195-204 | DOI: 10.1080/18366503.2018.1498147 The Journal of International Maritime Safety, Environmental Affairs, and Shipping is an open access journal publishing topics such as: ship design, marine pollution, maritime security, shipping port management and more. Find out how you can publish with the journal today. To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : Culture, Theory and Critique, Volume 59, Issue 3, August 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content Culture, Theory and Critique, Volume 59, Issue 3, August 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Articles Exceptionalism, metaphor and hybrid warfare Vaheed Ramazani Pages: 193-214 | DOI: 10.1080/14735784.2018.1478740 The vegetative city Andrea Mubi Brighenti Pages: 215-231 | DOI: 10.1080/14735784.2018.1478320 The 'secret code' of honour – on political enjoyment and the excrescence of fantasy Dominik Finkelde Pages: 232-261 | DOI: 10.1080/14735784.2018.1481761 A genealogical reading of security: power, politics and resistance Philippe Fournier Pages: 262-280 | DOI: 10.1080/14735784.2018.1481760 Political satire and its disruptive potential: irony and cynicism in Russia and the US | Maria Brock Pages: 281-298 | DOI: 10.1080/14735784.2018.1496843 'Like' Culture, Theory and Critique on Facebook for the latest news from the journal. To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Refractory hypoglycemia in a pediatric patient with desmoplastic small round cell tumor

Journal Name: Journal of Pediatric Endocrinology and Metabolism
Issue: Ahead of print


https://ift.tt/2NG8j1d

Cysteine cathepsins B, X and K expression in peri-arteriolar glioblastoma stem cell niches

Abstract

Glioblastoma (GBM) is the most lethal brain tumor also due to malignant and therapy-resistant GBM stem cells (GSCs) that are localized in protecting hypoxic GSC niches. Some members of the cysteine cathepsin family of proteases have been found to be upregulated in GBM. Cathepsin K gene expression is highly elevated in GBM tissue versus normal brain and it has been suggested to regulate GSC migration out of the niches. Here, we investigated the cellular distribution of cathepsins B, X and K in GBM tissue and whether these cathepsins are co-localized in GSC niches. Therefore, we determined expression of these cathepsins in serial paraffin sections of 14 human GBM samples and serial cryostat sections of two samples using immunohistochemistry and metabolic mapping of cathepsin activity using selective fluorogenic substrates. We detected cathepsins B, X and K in peri-arteriolar GSC niches in 9 out of 16 GBM samples, which were defined by co-expression of the GSC marker CD133, the niche marker stromal-derived factor-1α (SDF-1α) and smooth muscle actin as a marker for arterioles. The expression of cathepsin B and X was detected in stromal cells and cancer cells throughout the GBM sections, whereas cathepsin K expression was more restricted to arteriole-rich regions in the GBM sections. Metabolic mapping showed that cathepsin B, but not cathepsin K is active in GSC niches. On the basis of these findings, it is concluded that cathepsins B, X and K have distinct functions in GBM and that cathepsin K is the most likely GSC niche-related cathepsin of the three cathepsins investigated.

https://ift.tt/2mGCE4d

Comparative physiological behaviors of Ulva lactuca and Gracilariopsis lemaneiformis in responses to elevated atmospheric CO 2 and temperature

Abstract

Physiological metabolisms of seaweeds usually suffered climate changes in the field. Gracilariopsis lemaneiformis and Ulva lactuca, collected from Nan'ao Island, Shantou, China, were cultured under ambient and elevated CO₂ supply (390 and 800 μl L⁻¹), with low and high temperatures (15 °C and 25 °C) for 2 weeks, aiming to compare the difference of the main physiological metabolism between two seaweed species in response to the elevated CO₂ and high temperature. At 15 °C, the pH reduction in the culture medium caused by elevated CO₂ was larger in G. lemaneiformis than in U. lactuca. At 25 °C, elevated CO₂ significantly increased photosynthetic rates (P_n or P_g) and maintained constant respiratory rates (R_d) in G. lemaneiformis. However, for 25 °C-grown U. lactuca, the increment of CO₂ did not enhance the P_n (P_g) rates but rapidly decreased the R_d rates itself. With the higher R_d/P_g ratios in G. lemaneiformis than U. lactuca, the warming thereby promoted more allocation of photosynthetic products to respiratory consumption in G. lemaneiformis. Both P_g and R_d rates exhibited lower temperature acclimation in two seaweeds. In addition, elevated CO₂ markedly increased the relative growth rate (RGR) and phycobiliprotein (PB) contents at 25 °C, but exhibited no enhancement of chlorophyll a (Chl a), carotenoids (Car), soluble carbohydrate (SC), and soluble protein (SP) contents in G. lemaneiformis, with the reduction of SC when temperature increased only. We suggested that climate changes were probably a more benefit to U. lactuca than to G. lemaneiformis, inherently justifying the metabolism during G. lemaneiformis maricultivation.

https://ift.tt/2JUw6bp

Scholar : These new articles for Applied Developmental Science are available online

The online platform for Taylor & Francis Online content New for Applied Developmental Science and online now on Taylor & Francis Online: Original Articles Why do extracurricular activities prevent dropout more effectively in some high schools than in others? A mixed-method examination of organizational dynamics Julie McCabe, Véronique Dupéré, Eric Dion, Éliane Thouin, Isabelle Archambault, Sarah Dufour, Anne-Sophie Denault, Tama Leventhal & Robert Crosnoe Pages: 1-16 | DOI: 10.1080/10888691.2018.1484746 The relationship between pet ownership, social support, and internalizing symptoms in students from the first to fourth year of college Sandra B. Barker, Christine M. Schubert, Randolph T. Barker, Sally I-Chun Kuo, Kenneth S. Kendler & Danielle M. Dick Pages: 1-15 | DOI: 10.1080/10888691.2018.1476148 Retrospective report revisited: Long-term recall in European American mothers moderated by developmental domain, child age, person, and metric of agreement Marc H. Bornstein, Diane L. Putnick, Kyrsten M. Costlow & Joan T. D. Suwalsky Pages: 1-21 | DOI: 10.1080/10888691.2018.1462090 Refining the domain of civic engagement: Empirical findings from a multidimensional model in young adults in Chile Edmundo Varela & M. Loreto Martínez Pages: 1-13 | DOI: 10.1080/10888691.2018.1471995 Participation in organized activities among Mexican and other Latino youth in Los Angeles: Variation by mother's documentation status and youth's age Eileen Díaz McConnell, Rebecca M. B. White & Andrea Vest Ettekal Pages: 1-18 | DOI: 10.1080/10888691.2018.1449652 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Pollution assessment of heavy metal accumulation in the farmland soils of Beijing’s suburbs

Abstract

In this study, we used GIS to assess heavy metal concentrations and their spatial variations in Beijing's suburban farmlands. The Beijing soil heavy metal background values (background values), the primary standard of the Chinese Environmental Quality Standard of Soil (primary standard), and the Environmental Quality Standard of Green Food Production Site (green standard) were used as the standards for assessing soil heavy metals. Results showed that the average Hg value was higher than that of the primary standard. The Ni and Pb values were lower than the corresponding background values. From the percentage area, the concentration is 100% area with As, more than 93% area with Cr, Cu, Pb and Zn, and 67% area with Cd and Hg, meeting the primary standard; over 97% area met the green standard. The calculated Nemerow index showed that less than 3% of the samples were slightly polluted, indicating good environmental quality. But the accumulated pollution of Cd and Hg was relatively high in some areas which was mainly affected by the high density of the industry. The farmland soils in Beijing suburbs were found to be suitable for farming, but a small percentage of the soils exceeded the green standard; Cd and Hg levels require special attention.

https://ift.tt/2Lm5GoA

Spinal Cord Stimulation Combined with Anterior Cingulotomy to Manage Refractory Phantom Limb Pain

Background: Phantom limb pain (PLP) is an intractable and debilitating disease without satisfactory treatment options presently available. Central reorganization, peripheral changes, and psychiatric factors contribute to its development; thus, a neuropsychiatry-orientated combined therapy could be promising. Objectives: We used a combined strategy with the aims of demonstrating its therapeutic outcomes on PLP. Methods: The patient initially received spinal cord stimulation (SCS) implantation and then anterior cingulotomy (ACING) 2 years later. We administered the Hamilton Depression Scale-24, Hamilton Anxiety Scale, Pain Rating Index, Numerical Pain Rating Scale, and the Short Form (36) Health Survey to assess its outcomes at 5 time points, namely the time before performing SCS implantation, 1 year and 2 years after SCS implantation, and 1 year and 2 years after SCS combined with ACING. Results: Excellent pain relief and significant improvement in depression symptoms were observed in this patient with PLP who underwent SCS combined with ACING. Conclusions: This report suggests that SCS combined with ACING is efficacious for PLP. However, further studies are warranted.
Stereotact Funct Neurosurg 2018;96:1–5

https://ift.tt/2A4OXkg

A Case of Symptomatic Granular Cell Tumor of the Pituitary Treated with Stereotactic Radiosurgery

Background: Granular cell tumors (GCT) of the pituitary are rare. Surgery is considered the primary management option. However, complete resection is often difficult, and surgery is associated with high rates of postoperative complications. Aims: To report a unique case of pituitary GCT treated with stereotactic radiosurgery (SRS). Case Description: We report a case of a 40-year-old female with endocrine dysfunction who underwent stereotactic biopsy and then SRS for the management of a suprasellar granular cell tumor. Over the ensuing 10 years, tumor regression was observed. Thirteen years after SRS, the patient remained asymptomatic; however, follow-up MRI demonstrated tumor progression. Fifteen years after SRS, the patient required endoscopic endonasal surgery after developing a new optic neuropathy. Her images demonstrated further tumor growth beyond the targeted area. Conclusion: SRS resulted in long-term tumor control without additional endocrine dysfunction, but the onset of new optic neuropathy associated with delayed tumor growth prompted surgical decompression.
Stereotact Funct Neurosurg 2018;96:1–7

https://ift.tt/2mN3AQ5

Inositol-C2-PAF acts as a biological response modifier and antagonizes cancer-relevant processes in mammary carcinoma cells

Abstract

Purpose

Previous studies have identified alkyl-phospholipids as promising compounds for cancer therapy by targeting constituents of the cell membrane and different signaling pathways. We previously showed that the alkylphospholipid Inositol-C2-PAF inhibits the proliferation and migration of immortalized keratinocytes and the squamous carcinoma-derived cell line SCC-25. Here, we investigated the effect of this compound on growth and motility as well as its mode of action in mammary carcinoma-derived cell lines.

Methods

Using BrdU incorporation and haptotactic cell migration assays, we assessed the effects of Inositol-C2-PAF on MCF-7 and MBA-MB-231 cell proliferation and migration. The phosphorylation status of signaling molecules was investigated by Western blotting as well as indirect immunofluorescence analysis and capillary isoelectric focusing.

Results

We found that Inositol-C2-PAF inhibited the growth as well as the migration in MCF-7 and MBA-MB-231 cells. Furthermore, we found that this compound inhibited phosphorylation of the protein kinase Akt at serine residue 473, but had no impact on phosphorylation at threonine 308. Phosphorylation of other kinases, such as Erk1/2, FAK and Src, which are targeted by Inositol-C2-PAF in other cells, remained unaffected by the compound in the mammary carcinoma-derived cell lines tested. In MCF-7 cells, we found that IGF-1-induced growth, as well as phosphorylation of Akt^S473, mTOR and the tumor suppressor pRB, was inhibited in the presence of Inositol-C2-PAF. Moreover, we found that in these cells IGF-1 had no impact on migration and did not seem to be linked to full Akt activity. Therefore, MCF-7 cell migration appears to be inhibited by Ino-C2-PAF in an Akt-independent manner.

Conclusion

The antagonistic effects of Inositol-C2-PAF on cell migration and proliferation are indicative for its potential for breast cancer therapy, alone or in combination with other cytostatic drugs.

https://ift.tt/2AafCwb

Correction to: The versatile role of exosomes in cancer progression: diagnostic and therapeutic implications

In the title of above mentioned article the word 'versatile' had been replaced by 'multifaceted'.

https://ift.tt/2OgSy23

Interplay between NRF1, E2F4 and MYC transcription factors regulating common target genes contributes to cancer development and progression

Abstract

Background

Nuclear respiratory factor 1 (NRF1), historically perceived as a protein regulating genes controlling mitochondrial biogenesis, is now widely recognized as a multifunctional protein and as a key player in the transcriptional modulation of genes implicated in various cellular functions. Here, we present emerging data supporting novel roles of NRF1 in cancer development and progression through its interplay with the transcription factors E2F4 and MYC. To identify common human NRF1, E2F4 and MYC target genes, we analyzed the Encyclopedia of DNA Elements (ENCODE) NRF1 ChIP-Seq data. By doing so, we identified 9253 common target genes with NRF1, E2F4 and MYC binding motifs. NRF1 binding motifs were found to be present in genes operating in signaling pathways governing all hallmarks of malignant transformation and progression, including proliferation, invasion, self-renewal and apoptosis.

Conclusions

In addition to controlling mitochondrial biogenesis NRF1, in conjunction with E2F4 and MYC, may play a critical role in the acquisition of human cancer characteristics. Additionally, NRF1 may orchestrate both MYC and E2F4 to regulate common target genes linked to multiple networks in the development and progression of cancer. A comprehensive understanding of this dynamic interplay will set the stage, not only for the design of novel treatment strategies, but also for the discovery of pan-cellular transcription factor regulatory strategies to predict cancer risk, therapy response and patient prognosis.

https://ift.tt/2A59zsK

Scholar : Chemistry and Ecology, Volume 34, Issue 8, September 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content Chemistry and Ecology, Volume 34, Issue 8, September 2018 is now available online on Taylor & Francis Online. This new issue contains the following articles: Research Articles Nitrogen budget and its environmental loading in an urban ecosystem with the rapid urbanisation of China Yongqiang Zhao, Yuguo Wu & Lvbing Jiang Pages: 697-712 | DOI: 10.1080/02757540.2018.1501477 Effect of zinc oxide nanoparticles on the trace element contents of soils Asli Baysal & Hasan Saygın Pages: 713-726 | DOI: 10.1080/02757540.2018.1491556 Sediments distribution of trace metals in a coastal lagoon (Southern Sardinia, Mediterranean Sea): assessment of contamination and ecological risk Giulia Atzori, Violetta Aru, Flaminia Cesare Marincola, Laura Chiarantini, Daniela Medas, Giorgia Sarais & Serenella Cabiddu Pages: 727-746 | DOI: 10.1080/02757540.2018.1491557 Evaluation of the effect of antimicrobials in marine cultures, using the copepod Acartia tonsa as a bioindicator Laís Fernanda de Palma Lopes, Vanessa Ochi Agostini, Sanye Soroldoni Guimarães & Erik Muxagata Pages: 747-761 | DOI: 10.1080/02757540.2018.1482886 Biosorption of Cr(VI) from wastewater using Sorghastrum Nutans L. Nash Ganesan Surendran & Saroj Sundar Baral Pages: 762-785 | DOI: 10.1080/02757540.2018.1487407 Heavy metal phyto-technologies from Ramsar wetland plants: green approach Prabhat Kumar Rai Pages: 786-796 | DOI: 10.1080/02757540.2018.1501476 Hoping to have your article read by anyone, anywhere and at any time? Find out more about publishing open access with Ecosystem Health and Sustainability. To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Randomized controlled trial of a self-administered five-day antiseptic bundle versus usual disinfectant soap showers for preoperative eradication of Staphylococcus aureus colonization.

Related Articles

Randomized controlled trial of a self-administered five-day antiseptic bundle versus usual disinfectant soap showers for preoperative eradication of Staphylococcus aureus colonization.

Infect Control Hosp Epidemiol. 2018 Jul 24;:1-9

Authors: Kline SE, Neaton JD, Lynfield R, Ferrieri P, Kulasingam S, Dittes K, Glennen A, Jawahir S, Kaizer A, Menk J, Johnson JR

Abstract
OBJECTIVE: To determine the efficacy in eradicating Staphylococcus aureus (SA) carriage of a 5-day preoperative decolonization bundle compared to 2 disinfectant soap showers, with both regimens self-administered at home.
DESIGN: Open label, single-center, randomized clinical trial.
SETTING: Ambulatory orthopedic, urologic, neurologic, colorectal, cardiovascular, and general surgery clinics at a tertiary-care referral center in the United States.ParticipantsPatients at the University of Minnesota Medical Center planning to have elective surgery and not on antibiotics.
METHODS: Consenting participants were screened for SA colonization using nasal, throat, axillary, and perianal swab cultures. Carriers of SA were randomized, stratified by methicillin resistance status, to a decolonization bundle group (5 days of nasal mupirocin, chlorhexidine gluconate [CHG] bathing, and CHG mouthwash) or control group (2 preoperative showers with antiseptic soap). Colonization status was reassessed preoperatively. The primary endpoint was absence of SA at all 4 screened body sites.
RESULTS: Of 427 participants screened between August 31, 2011, and August 9, 2016, 127 participants (29.7%) were SA carriers. Of these, 121 were randomized and 110 were eligible for efficacy analysis (57 decolonization bundle group, 53 control group). Overall, 90% of evaluable participants had methicillin-susceptible SA strains. Eradication of SA at all body sites was achieved for 41 of 57 participants (71.9%) in the decolonization bundle group and for 13 of 53 participants (24.5%) in the control group, a difference of 47.4% (95% confidence interval [CI], 29.1%-65.7%; P<.0001).
CONCLUSION: An outpatient preoperative antiseptic decolonization bundle aimed at 4 body sites was significantly more effective in eradicating SA than the usual disinfectant showers (ie, the control).Trial RegistrationClinicalTrials.gov identifier: NCT02182115.

PMID: 30037355 [PubMed - as supplied by publisher]

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Evaluation of stacked resonators to enhance the performance of a surface receive-only array for prostate MRI at 3 Tesla

Publication date: Available online 25 July 2018

Source: Magnetic Resonance Imaging

Author(s): Jorge Chacon-Caldera, Alexander Fischer, Matthias Malzacher, Yannik Vetter, Mathias Davids, Martina Flöser, Christopher Stumpf, Lothar R. Schad

Abstract

Prostate MRI is an important tool to diagnose and characterize cancer. High local sensitivity and good parallel imaging performance are of paramount importance for diagnostic quality and efficiency. The purpose of this work was to evaluate stacked resonators as part of a surface receiver array for prostate MRI at 3 Tesla. A base array of 6-channels consisting of a flexible anterior and a rigid posterior part were built each with three loop coils. A pair of stacked resonators was added concentrically to the center loops (anterior and posterior) of the base array. The evaluated stacked resonators were butterflies, composites and dipoles which yielded a total of three 8-channel arrays. The arrays were compared using noise correlations and single-channel signal-to-noise ratio maps in a phantom. Combined signal-to-noise ratio maps and parallel imaging performances were measured and compared in vivo in 6 healthy volunteers. The results were compared to the base and a commercial array. The SNR values in the prostate yielded by all the arrays were not statistically different using fully sampled k-space. However, significant differences were found in the parallel imaging performance of the arrays. More specifically, up to 88% geometric factor reduction was found compared to the commercial array and up to 83% reduction compared to the base array using butterfly coils. Thus, signal-to-noise ratio improvements were observed with stacked resonators when using parallel imaging. The use of stacked elements, in particular butterfly coils, can improve the performance of a base array consisting solely of single loops when using parallel imaging. We expect prostate MRI at 3 Tesla to benefit from using combinations of single loops and stacked resonators.

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Allergic Contact Dermatitis To Personal Care Products And Topical Medications In Adults With Atopic Dermatitis

Publication date: Available online 25 July 2018

Source: Journal of the American Academy of Dermatology

Author(s): Supriya Rastogi, Kevin R. Patel, Vivek Singam, Jonathan I. Silverberg

ABSTRACT

Background

Atopic dermatitis (AD) is associated with skin-barrier disruption, immune dysregulation, and application of emollients and topical medications, which may predispose towards developing allergic contact dermatitis (ACD).

Objective(s)

To determine the predictors of ACD and relevant allergens in AD.

Methods

A retrospective chart review was performed of 502 adults (age ≥18 years) who were patch-tested to an expanded allergen series from 2014-2017.

Results

Overall, 108 (21.5%) had current AD and 109 (21.7%) had past AD. Patients with vs. without current AD had similar proportions of any positive (+/++/+++: 80 [74.1%] vs. 254 [64.5%]; Chi-square, P=0.06), stronger (++/+++: 34 [31.5%] vs. 102 [25.9%], P=0.25) and irritant (56 [51.9%] vs. 188 [47.7%], P=0.45) patch test reactions. AD patients had significantly higher rates of positive reactions to ingredients in personal care products and topical medications, including fragrance mix II (P=0.04), lanolin (P=0.03), bacitracin (P=0.04), cinnamal (P=0.02), budesonide (P=0.01), tixocortol (P=0.02), and chlorhexidine (P=0.001); relevance was established in >90% of these reactions. Polysensitization occurred more commonly in patients with vs. without AD (35 [32.4%] vs. 75 [19.0%], P=0.01).

Limitations

Study performed at a single center.

Conclusion

AD patients had more positive patch test reactions to ingredients in personal care products, topical steroids and antibiotics.

https://ift.tt/2OhiEC2

Longevity of composite build-ups without posts—10-year results of a practice-based study

Abstract

Aim

The aim of this prospective, non-interventional, multi-center, practice-based study was, firstly, to evaluate the longevity of composite build-ups in endodontically treated teeth (ETT) without post placement and, secondly, to analyze factors influencing the success of these composite build-ups.

Methodology

Each of seven general dental practitioners placed up to 50 composite build-ups without additional posts in ETT. Teeth were restricted to incisors, canines, and premolars. Several clinical data were recorded for 192 coronal restorations on ETT in 192 patients. Cox proportional hazard models were applied to analyze associations between clinical factors and time until failure.

Results

Within a follow-up period of 10 years, 167 restorations were judged as successful [mean success time, 110 (105–115) months] and 180 teeth survived [mean survival time, 114 (110–119) months]. The main failure type was fracture of the restoration (n = 15). The annual failure rate was 2.4%. In bivariate Cox regression, both factors such as number of restored tooth surfaces and adhesive were significantly associated with the failure rate. In multivariate Cox proportional hazards regression, none of the investigated factors were significantly associated with the failure rate.

Conclusion

For composite build-ups in ETT without post placement, high success rates could be found after up to 10 years of observation time. Within the limitations of the present study, none of the analyzed factors such as "tooth type" or "number of restored tooth surfaces" was a significant predictor for the failure rate.

Clinical relevance

Endodontically treated teeth can be successfully directly restored with composite build-ups even when no additional post is inserted.

Trial registration

The study was registered in the German Clinical Trials Register (DRKS-ID: DRKS00012882).

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An Update on Calciphylaxis

Abstract

Calciphylaxis, also known as calcific uremic arteriolopathy and uremic small artery disease with medial wall calcification and intimal hyperplasia, is a multifactorial cutaneous vascular disease characterized by chronic, painful, non-healing wounds that occur frequently in patients with chronic kidney disease, predominantly in those with end-stage renal disease. The pathogenesis remains unclear, and the development of calciphylaxis lesions depends on medial calcification, intimal fibrosis of arterioles and thrombotic occlusion. Despite an increase in reports of calciphylaxis in the literature and clinical recognition of demographic characteristics and risk factors associated with calciphylaxis, it remains a poorly understood disease with high morbidity and mortality. In this review, we analyze and summarize the clinical manifestations, pathogenesis and pathophysiology, histopathology, differential diagnosis, diagnostic workup and treatment modalities for calciphylaxis. Because of the lack of consensus regarding the optimal approach to and treatment of this disorder, a high degree of clinical suspicion, early diagnosis, and multimodal and multidisciplinary treatment in collaboration with dermatology, nephrology, wound care, nutrition and pain management specialties may improve survival in patients with calciphylaxis.

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Pattern of care of adjuvant radiotherapy in male breast cancer patients in clinical practice: an observational study

Abstract

Background and purpose

Due to the rarity of male breast cancer (male BC), no consensus has been reached regarding the most appropriate curative treatment strategy. The objective of the present observational study was to identify patient and tumor characteristics and assess the role of radiotherapy (RT) in clinical practice.

Methods

Between 1998 and 2014, data of male BC patients treated at two breast centers were consecutively collected and retrospectively analyzed. Patients were stratified based on the addition of adjuvant RT. Data on overall survival (OS) and local recurrence-free survival (LRFS) were estimated with the Kaplan–Meier method and compared by the log-rank test.

Results

A consecutive cohort of 58 male BC patients was evaluated. Median follow-up was 56 months. Twenty-one patients (36.2%) received adjuvant RT. Overall, patients undergoing postoperative RT were characterized by more high-risk features. Patients receiving postoperative RT had significantly more frequently a high UICC stage (50 vs. 9.7% UICC III, p = 0.018) and positive lymph nodes as compared to patients undergoing surgery alone (65 vs. 34.4% pN+, p = 0.046). Accordingly, there was a higher proportion of patients receiving axillary lymph node dissection in the RT group (71.4 vs. 35.6%). Mastectomy was performed in 31/37 (86.1%) in the surgery group as compared to 14/21 (66.7%) in patients receiving postoperative RT. In addition, RT patients were more likely to receive endocrine therapy (78.9 vs. 39.3%, p = 0.016). Outcome was not significantly different between the groups (5-year LRFS: 89.8 vs. 80.0%, p = 0.471 and 5‑year OS 88.4 vs. 88.9%, p = 0.819).

Conclusion

The present observational study evaluated the pattern of care in male BC patients treated in clinical practice. Due to its rarity, randomized clinical trials are unlikely and male BC remains an entity with a poor evidence base. Nevertheless, RT remains a crucial component of the multidisciplinary treatment strategy in male BC.

https://ift.tt/2Lxsa5g

Precocious pubertal events in Chilean children: ethnic disparities

Abstract

Purpose

Puberty onset exhibits remarkable inter-individual and ethnic differences. 5% of Chileans are indigenous but puberty ethnic disparities have not been studied. We aim for evaluating precocious puberty prevalence in children with Mapuche ancestry vs non-indigenous Chilean children (according to their surnames).

Methods

Longitudinal cohort study: 1003 children (50.2% girls) participating in the Growth and Obesity Chilean Cohort Study (GOCS) were studied. Annual anthropometry was measured since 4–7 years. Subsequently, Tanner staging and anthropometry were measured every 6 months. In girls, Tanner stage was assessed by breast palpation and in boys by testicular volume measurements. The cohort was stratified in three groups depending on Mapuche surname numbers as follows: (A) no indigenous surnames (n = 811), (B) one to two indigenous surnames (n = 147), and (C) three or more indigenous surnames (n = 45). We evaluated the prevalence of precocious thelarche, pubarche, menarche and gonadarche (testicular volume ≥ 4 ml—G2), using a cutoff age of 8 years in girls and 9 years in boys while controlling for socioeconomic status, body mass index, waist circumference, IGF-1 and DHEAS at 7 years.

Results

In girls, no significant differences were observed. On the contrary, in boys, precocious gonadarche prevalence was higher in group C (29.2%) vs group A (6.0%) and vs group B (10.5%) (p =0.001, p = 0.004, respectively). Increased precocious gonadarche and pubarche risks in group C were observed even after adjustment [OR 7.31; 95% IC (2.32–23.51); p = 0.001] and [OR 6.17, 95% CI (1.62–23.49); p = 0.008], respectively.

Conclusion

Indigenous origin in Chile is an independent risk factor for precocious gonadarche and pubarche in boys but not in girls.

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Staffing Metrics in Mohs Surgery

No abstract available

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Commentary on Patient Preferences for the Treatment of Basal Cell Carcinoma and Squamous Cell Carcinoma: A Mapping Review of Discrete Choice Experiments

No abstract available

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Successful Treatment of a Scleroderma-Associated Leg Ulcer With Endovenous Laser Ablation

No abstract available

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Skin and Soft Tissue Surgery in the Office Versus Operating Room Setting: An Analysis Based on Individual-Level Medicare Data

BACKGROUND The relative volume of skin and soft tissue excision and reconstructive procedures performed in the outpatient office versus facility (ambulatory surgical center or hospital) differs by specialty, and has major implications for quality of care, outcomes, development of guidelines, resident education, health care economics, and patient perception. OBJECTIVE To assess the relative volume of surgical procedures performed in each setting (office vs ambulatory surgery center [ASC]/hospital) by dermatologists and nondermatologists. METHODS A cross-sectional analytical study was performed using the Medicare public use file (PUF) for 2014, which includes every patient seen in an office, ASC, or hospital in the United States billed to Medicare part B. Data were divided by physician specialty and setting. RESULT A total of 9,316,307 individual encounters were included in the Medicare PUF. Dermatologists account for 195,001 (2.1%) of the total. Dermatologists were more likely to perform surgical procedures in an office setting only (odds ratio 5.48 [95% confidence interval 5.05–5.95], p

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Syringocystadenoma Papilliferum in Coexistence With Verrucous Carcinoma on the Face

No abstract available

https://ift.tt/2LMV520

Impact of Mohs Micrographic Surgery on Tumor Staging of Cutaneous Squamous Cell Carcinoma: A Comparison of the 7th and 8th Editions of the American Joint Committee on Cancer Guidelines

BACKGROUND Based on current AJCC-7 guidelines for staging cutaneous squamous cell carcinoma (cSCC), patients with T2 tumor staging represent a prognostically heterogeneous group. The new AJCC-8 guidelines seek to provide improved stratification by inclusion of independent risk factors in the T3 category. These features may be identified in tissue stages during Mohs micrographic surgery (MMS). Thus, low-risk cSCC may be upstaged after MMS, impacting prognosis, additional evaluation, and adjuvant nonsurgical treatment. OBJECTIVE To examine the impact of MMS on cSCC staging under AJCC-7 and AJCC-8 guidelines. MATERIALS AND METHODS The medical record was queried for patients who underwent MMS for cSCC. Data were recorded for 190 MMS specimens and corresponding biopsies. Tumor staging according to AJCC-7 and AJCC-8 was assigned. RESULTS High-risk histologic features are more likely identified with MMS than biopsies. Cutaneous squamous cell carcinoma was equally likely to be upstaged during MMS under both AJCC-7 and AJCC-8, with 10.5% being classified as AJCC-8 T3. Seventy percent of these were only classified as T3 after MMS. Upstaging to T3 during MMS under AJCC-8 is less likely than upstaging to T2 under AJCC-7. CONCLUSION Mohs surgeons have a significant impact on accurate staging of high-risk cSCC. AJCC-8 improves risk stratification of cSCC.

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Patient Preferences for the Treatment of Basal Cell Carcinoma: A Mapping Review of Discrete Choice Experiments

BACKGROUND Treatment options for skin cancer differ in several attributes including efficacy, convenience, cost, scarring, and side effects. Discrete choice experiments (DCEs) provide insight into how patients value the attributes of their treatment options. OBJECTIVE To review published DCE data on skin cancer treatment. METHODS PubMed database was systematically searched using predefined keyword combinations for articles pertaining to skin cancer treatment and DCEs through October 2017. Three hundred seventy unique article titles were evaluated, and titles that did not mention skin cancer treatment were excluded leaving 44 studies. Abstracts of 44 studies were examined, and studies that used DCEs to query preference for skin cancer treatment were included in this mapping review. RESULTS Six articles that used DCEs to query patient preference for skin cancer treatment were reviewed. All DCE studies identified focused on basal cell carcinoma. CONCLUSION Discrete choice experiments are a rigorous method of eliciting patient preference for skin cancer surgery. Recurrence was the most important attribute in 4 of the 6 studies reviewed. Appearance was the most important attribute in 1 study and the second most important in 3 studies. Comparisons between studies are limited by the heterogeneity of the treatment attributes and levels included in DCEs.

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Liposarcoma Preoperatively Diagnosed as Lipoma: 10-Year Experience at a Single Institution

BACKGROUND On rare occasions, a lesion preoperatively diagnosed as a lipoma is ultimately diagnosed as a liposarcoma. It is important to differentiate liposarcomas from lipomas preoperatively. OBJECTIVE To examine characteristic features of liposarcomas preoperatively diagnosed as lipomas. METHODS Patients (n = 637) who underwent resection of tumors preoperatively diagnosed as lipomas from January 2006 to October 2016 were retrospectively reviewed. RESULTS Based on pathological examination, 8 of 637 lesions were diagnosed as liposarcomas postoperatively. All the liposarcomas were well-differentiated liposarcomas. The rate of male patients was higher (87.5% vs 38.9%) and the size of tumors was larger (8.75 vs 4.64 cm) in these cases than in accurately diagnosed lipoma cases. On imaging, nonfatty septa were more frequently observed (71.4% vs 20.0%) and were thicker (2.22 vs 1.33 mm) than in true lipoma cases. CONCLUSION If the patient with a lipomatous tumor is male and the tumor is large, we should consider the possibility of it being a liposarcoma. A thick internal septum in the image findings is a good predictor of malignancy.

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A Perineurioma Treated With Mohs Micrographic Surgery

No abstract available

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Dermatologic Surgery and Reconstruction Photograph Booklet as a Tool to Improve Informed Consent Before Skin Surgery

BACKGROUND Skin surgery is a high-risk area of litigation and tools to improve consent are welcomed. OBJECTIVE This project aimed to strengthen the consenting process for dermatological surgery by introducing a photograph booklet. MATERIALS AND METHODS The authors designed a booklet containing skin surgery images. Patients attending surgery completed an anonymous questionnaire immediately after their procedures before the booklet introduction (Group 1). The questionnaire was then repeated (Group 2) with the introduction of the photograph booklet during consent. The authors looked for changes in the following: understanding of procedure, scar, and postoperative care as well as addressing of patients' concerns using a subjective scale of 1 to 5 (1 = poor, 2 = fair, 3 = okay, 4 = good, and 5 = great). RESULTS Results indicated greater patient satisfaction among patients in Group 2 who had been shown relevant surgical images compared with Group 1, with improvements from ratings of 3 and 4 on the scale to 5. The difference in the 2 groups for the highest ratings of 5/5 was significant (p

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Vulvar Lymphangioma Circumscriptum Treated With Fractional Ablative Erbium: Yttrium Aluminium Garnet Laser

No abstract available

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In Vivo Degradation of Crosslinked Hyaluronic Acid Fillers by Exogenous Hyaluronidases

BACKGROUND An advantage of hyaluronic acid (HA)-based fillers is reversibility. OBJECTIVE To evaluate the ability of 2 hyaluronidases to degrade 3 HA-based fillers using a novel in vivo model. MATERIALS AND METHODS Rats were injected with 3 HA fillers (HYC-24L+, VYC-20L, and RES-L) to create a projecting bolus. After 4 days, recombinant human hyaluronidase (HX) or ovine hyaluronidase (VIT) was administered at (1) varying doses (5 U, 10 U, or 30 U per 0.1 mL filler) or (2) different dilutions (10 U diluted 3-fold). The impact of tissue integration was assessed by administering 10 U/0.1 mL filler 4 weeks after filler injection. Three-dimensional images quantified projection loss over 72 hours. RESULTS Complete loss of projection was achieved for all fillers with the highest HX and VIT doses; lower doses achieved less degradation. No difference in degradation was observed between HYC-24L+ and VYC-20L using HX or VIT. RES-L was slightly more degraded with 10 U VIT but not with 10 U HX. Enzyme dilution resulted in less degradation. Tissue integration did not impact the degree of degradation. CONCLUSION This model incorporates the biological system while controlling variables including filler depth and volume and location of hyaluronidase delivery. Hyaluronic acid filler degradation by exogenous hyaluronidase was not hindered by differences among fillers.

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Superficial CD34-Positive Fibroblastic Tumor Successfully Treated With Mohs Micrographic Surgery: ERRATUM

No abstract available

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Examining the Efficacy of Calcium Hydroxylapatite Filler With Integral Lidocaine in Correcting Volume Loss of the Jawline—A Pilot Study

BACKGROUND Patients seek 3-dimensional volume restoration of the jawline to obtain a "defined" line. Injection of filler into the jawline is not approved by the Food and Drug Administration; however, dermatologists have injected this area with positive results, minimal adverse events, and high patient satisfaction. OBJECTIVE This study explores the efficacy of premixed calcium hydroxylapatite filler with integral lidocaine [CaHA(+)] to correct volume defects of the jawline. It examines the longevity, safety, and patient satisfaction (up to 12 months) of CaHA(+) for jawline volume loss correction. MATERIALS AND METHODS This is a single-investigator, nonblinded study. Twenty subjects received CaHA(+) filler injection in the jawline, with follow-up evaluations conducted at 14 days, 6 weeks, and 3, 6, 9, and 12 months. RESULTS CaHA(+) injection in the jawline results in statistically significant restoration in volume and improvement in appearance lasting up to 12 months. Overall, subjects report "moderate" improvement on the Global Aesthetic Improvement Scale. CONCLUSION It is important for cosmetic surgeons and dermatologists to have access to data on the efficacy and safety of injectables. The data obtained in this study show that CaHA(+) is an effective and safe option to correct jawline volume loss and is associated with high patient satisfaction.

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Repair of a Full-Thickness Alar Defect

No abstract available

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Topical Botulinum Toxin Type A Liposomal Cream for Primary Axillary Hyperhidrosis: A Double-Blind, Randomized, Split-Site, Vehicle-Controlled Study

BACKGROUND Despite its effectiveness in treating primary axillary hyperhidrosis (PAH), topical botulinum toxin type A (BTX-A) is highly resistant to transdermal absorption. Topical BTX-A liposomal cream is recommended as a novel, noninvasive modality to enhance skin penetration. OBJECTIVE To evaluate the efficacy and safety of topical BTX-A liposomal cream in comparison with liposomal vehicle cream alone in the treatment of PAH. MATERIALS AND METHODS A prospective, randomized, double-blinded, split-site study was conducted in 20 subjects, aged 18 to 50 years, all of whom had symmetrical axillary sweating with Hyperhidrosis Disease Severity Scale scores between 2 to 4. All subjects were double-blinded to treatment regimens and randomly given 2 bottles, one containing topical BTX-A liposomal cream and one containing the vehicle cream without BTX-A, to be applied consistently to the same axilla nightly for 7 consecutive days. Clinical improvement and adverse reactions were evaluated at every follow-up visit. RESULTS Axillary skin treated with topical BTX-A demonstrated superior sweat reduction and patient satisfaction to vehicle cream–treated axillary skin, with clinical and statistical significance, at baseline, weeks 2, 4, 6, and 8 of follow-up, without adverse effects. CONCLUSION Topical BTX-A liposomal cream pharmaceutically enhances drug delivery, is painless, cost-effective, and overall an innovative treatment of PAH.

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Improving Quality of Life Measurement in Skin Cancer Patients: Clinical Correlate for the Skin Cancer Index

No abstract available

https://ift.tt/2NIRVge

Fractional Carbon Dioxide Laser Resurfacing in Combination With Potent Topical Corticosteroids for Hypertrophic Burn Scars in the Pediatric Age Group: An Open Label Study

BACKGROUND Lasers and potent topical corticosteroids are used as therapeutic options in hypertrophic burn scars. OBJECTIVE To assess the therapeutic effect of fractional CO2 laser resurfacing in combination with potent topical corticosteroids on hypertrophic burn scars in pediatric age group. METHODS Ten children (5–12 years) with postburn hypertrophic scars were treated with 3 to 5 sessions of fractional CO2 laser resurfacing at 1-month intervals, and triamcinolone suspension was applied immediately after each laser session. Patients were also instructed to apply clobetasol propionate gel for 1 week after each laser session. Response to treatment was assessed using Vancouver Scar Scale (VSS) and Physician Global Assessment (PGA). Tolerability for the procedure and adverse effects were also assessed. RESULTS Laser sessions were well tolerated under the effect of topical or local anesthesia. At the time of final assessment, there was mean reduction of 4.2 (range: 2.8–7) in VSS. Reduction of VSS by ≥4 points was observed in 8 of 10 cases, whereas PGA revealed excellent response in 6 of 10 cases. No significant adverse effects were reported by any patient. CONCLUSION Fractional CO2 laser resurfacing in combination with potent topical steroids leads to significant therapeutic benefits in children with postburn hypertrophic scars.

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How We Do It: 3-Nick Technique for Mohs Tissue Mapping

No abstract available

https://ift.tt/2LPEcDR

Effects of 1,540-nm Fractional Nonablative Erbium and 2,940-nm Fractional Ablative Erbium on p53 Epidermal Expression After 3 months: A Split-Face Interventional Study

BACKGROUND Expression of p53 by keratinocytes may be important in the pathogenesis of skin cancer induced by ultraviolet light. OBJECTIVE We used side-by-side nonablative and ablative erbium fractional laser resurfacing to assess the effects on expression of p53 by facial keratinocytes. METHODS Ten female patients (age range, 50–63 years) with Fitzpatrick skin Types I–IV and clinical signs of photoaging underwent erbium fractional laser resurfacing (nonablative, 1,540-nm; ablative, 2,940-nm) on opposite sides of the face. Skin biopsies were obtained before treatment and 3 months after treatment for comparison with control biopsies of face and inner arm, quantifying p53 in immunostained tissue sections. RESULTS Only ablative (2,940-nm) treatments produced a statistically significant reduction in p53 scoring after 3 months. The histologic appearance of skin after ablative resurfacing more closely resembled inner arm skin (rather than facial skin) of control subjects. CONCLUSION Epidermal repopulation with p53-negative keratinocytes through ablative erbium fractional laser resurfacing may diminish the risk of eventual malignancy in photoaged skin.

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The Potential Benefit of Pre-emptive Leukotriene Inhibitor Treatment to Breast Augmentation/Mastopexy Surgery

No abstract available

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Facial Transplantation: Highlighting the Importance of Clinical Vigilance in Donor Selection

No abstract available

https://ift.tt/2LkcL9c