Scholar : ΑΚΟΥΣΤΙΚΟ - νέα αποτελέσματα

[PDF] Ανάπτυξη νοητικών χαρτών από άτομα με οπτική αναπηρία με τη χρήση ενός ρομποτικού παιχνιδιού.

Μ Τερζίδου - 2018

Page 1. ΠΑΝΕΠΙΣΤΗΜΙΟ ΜΑΚΕΔΟΝΙΑΣ ΣΧΟΛΗ ΚΟΙΝΩΝΙΚΩΝ,
ΑΝΘΡΩΠΙΣΤΙΚΩΝ ΕΠΙΣΤΗΜΩΝ ΚΑΙ ΤΕΧΝΩΝ Τμήμα Εκπαιδευτικής και
Κοινωνικής Πολιτικής Πρόγραμμα Μεταπτυχιακών Σπουδών «Ειδική Αγωγή …

 

Δημιουργία λίστας των ειδοποιήσεών μου

Ακύρωση ειδοποίησης

Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.

Pre-Distribution of Potassium Iodide (KI) and Maintenance of KI Stockpile Called for in Advance of Multi-Organizational Meeting

ATA supports dialogue on the international harmonization of radiological emergency preparedness around nuclear power stations

The American Thyroid Association^® is the leading organization devoted to thyroid biology and to the prevention and treatment of thyroid disease through excellence in research, clinical care, education, and public health.  It has come to our attention that several organizations to include Greenpeace Canada, Beyond Nuclear and a coalition of Michigan civil society organizations jointly hold a meeting at the University of Detroit Mercy in Detroit, Michigan for a dialogue on the international harmonization of radiological emergency preparedness around nuclear power stations.  One issue of particular concern is in regard to ensuring appropriate potassium iodine distribution within the emergency planning zone (EPZ) surrounding Fermi Unit 2 at the nuclear power station in Monroe, Michigan.

As stated in the American Thyroid Association^® (ATA^®) Scientific Statement on the Use of Potassium Iodide Ingestion in a Nuclear Emergency which was published in the journal Thyroid^® in 2017 (Vol 27, Number 7; Pages: 865-877), the American Thyroid Association calls for pre-distribution of potassium iodide (KI) to individual households residing within a minimum of the 10-mile emergency planning zone (EPZ) of an actively operating U.S. nuclear power plant.  The ATA also calls for maintenance of a stockpile of potassium iodine in a greater than 10 out to 50-mile ring out from nuclear power points and is to be held in local public facilities such as schools, hospitals, Clinics, post offices, and police as well as fire stations for distribution upon notification by local health officials.

The effectiveness of KI for protection of the thyroid from radioiodine fallout from a nuclear emergency is predicated on prompt use that at the same time does not delay evacuation from the affected area. It is therefore somewhat disconcerting that a study by the Michigan Department of Community Health published in 2012 found that only 5.3% of eligible residences in the EPZ of one of three nuclear power plants in MI had redeemed KI vouchers and of those individuals who had redeemed KI vouchers ~ 50% were unaware of when to take KI or that it could protect the thyroid from radiation exposure.  Of those identified as not having utilized a KI voucher, 48% were either unaware or had forgotten that such a program exists.

The ATA^® would like to again emphasize that prophylactic KI administrator should be part of a nuclear emergency plan that includes evacuation, sheltering, and the avoidance of contaminated food, milk and water ingestion in the event of a nuclear emergency.  The ATA calls for ready access to KI for the U.S. population living in nuclear power EPZs from the U.S. Department of Health and Human Services' National Pharmaceutical Stockpile under appropriate regulatory guidance. The ATA also supports attempts to harmonize KI distribution strategies with Canada particularly in US-Canadian border localities that fall within EPZs from the same nuclear power plant.

###

The American Thyroid Association (ATA) is the leading worldwide organization dedicated to the advancement, understanding, prevention, diagnosis, and treatment of thyroid disorders and thyroid cancer. ATA is an international, individual membership organization for over 1,700 clinicians and researchers from 43 countries around the world, representing a broad diversity of medical disciplines. It also serves the public, patients and their families through education and awareness efforts.

Celebrating its 95th anniversary, ATA delivers its mission through several key endeavors: the publication of highly regarded monthly journals, Thyroid^®, Clinical Thyroidology^®, VideoEndocrinology™, and Clinical Thyroidology for the Public; annual scientific meetings; biennial clinical and research symposia; research grant programs for young investigators; support of online professional, public, and patient educational programs; and the development of guidelines for clinical management of thyroid disease.

Find out more about ATA at www.thyroid.org.

The post Pre-Distribution of Potassium Iodide (KI) and Maintenance of KI Stockpile Called for in Advance of Multi-Organizational Meeting appeared first on American Thyroid Association.

https://ift.tt/2qD2SqB

Scholar : ΒΑΣΗ ΚΡΑΝΙΟΥ - νέα αποτελέσματα

[PDF] Στρατηγικός σχεδιασμός των μουσείων: σύγχρονες τάσεις και αντιλήψεις: η περίπτωση του αρχαιολογικού μουσείου Θεσσαλονίκης και η προσαρμογή του στη νέα …

Α Παπαδημητροπούλου - 2018

… είναι η ανάλυση στη σύγχρονη πραγματικότητα του μουσειακού μάρκετινγκ
στα πλαίσια του οποίου χρησιμοποιούνται πλέον ψηφιακά εργαλεία στη
βάση της πελατοκεντρικής … εμπειρία", "πολυμέσα στο μουσείο" κ.α., με χρονική …

 

Δημιουργία λίστας των ειδοποιήσεών μου

Ακύρωση ειδοποίησης

Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.

Scholar : ΦΩΝΗ - νέα αποτελέσματα

[PDF] Το φαινόμενο της εξάρτησης και μοντέλα χρήσης ομάδων ρυθμού και κρουστών στην αντιμετώπιση της

Π Τσακαλακίδου - 2018

Page 1. ΠΑΝΕΠΙΣΤΗΜΙΟ ΜΑΚΕΔΟΝΙΑΣ ΣΧΟΛΗ ΚΟΙΝΩΝΙΚΩΝ,
ΑNΘΡΩΠΙΣΤΙΚΩΝ ΣΠΟΥΔΩΝ ΚΑΙ ΤΕΧΝΩΝ ΤΜΗΜΑ ΜΟΥΣΙΚΗΣ
ΕΠΙΣΤΉΜΗΣ ΚΑΙ ΤΕΧΝΗΣ ΠΡΟΓΡΑΜΜΑ ΜΕΤΑΠΤΥΧΙΑΚΩΝ ΣΠΟΥΔΩΝ …

[PDF] H μουσικοθεραπεία στην τρίτη ηλικία: Alzheimer's μελέτη περίπτωσης

Α Κάργιου - 2018

Page 1. ΠΑΝΕΠΙΣΤΗΜΙΟ ΜΑΚΕΔΟΝΙΑΣ ΣΧΟΛΗ ΚΟΙΝΩΝΙΚΩΝ,
ΑΝΘΡΩΠΙΣΤΙΚΩΝ ΣΠΟΥΔΩΝ ΚΑΙ ΤΕΧΝΩΝ ΤΜΗΜΑ ΜΟΥΣΙΚΗΣ
ΕΠΙΣΤΗΜΗΣ ΚΑΙ ΤΕΧΝΗΣ ΠΡΟΓΡΑΜΜΑ ΜΕΤΑΠΤΥΧΙΑΚΩΝ ΣΠΟΥΔΩΝ …

[PDF] Στιγμές με νόημα στη διαδικασία της μουσικοθεραπείας

Κ Καλογεροπούλου - 2018

Page 1. ΠΑΝΕΠΙΣΤΗΜΙΟ ΜΑΚΕΔΟΝΙΑΣ ΤΜΗΜΑ ΜΟΥΣΙΚΗΣ ΕΠΙΣΤΗΜΗΣ ΚΑΙ ΤΈΧΝΗΣ
ΠΡΟΓΡΑΜΜΑ ΜΕΤΑΠΤΥΧΙΑΚΩΝ ΣΠΟΥΔΩΝ «ΜΟΥΣΙΚΗ ΚΑΙ ΚΟΙΝΩΝΙΑ» ΚΑΤΕΥΘΥΝΣΗ:
ΜΟΥΣΙΚΟΘΕΡΑΠΕΙΑ ΤΙΤΛΟΣ ΔΙΠΛΩΜΑΤΙΚΗΣ ΕΡΓΑΣΙΑΣ …

 

Δημιουργία λίστας των ειδοποιήσεών μου

Ακύρωση ειδοποίησης

Αυτή η ειδοποίηση αποστέλλεται από τον Μελετητή Google. Ο Μελετητής Google είναι μια υπηρεσία που παρέχεται από την Google.

Clinical Thyroidology®High-Impact Articles

FREE ACCESS through April 30, 2018.
Read Now:

Circulating BRAF V600E Levels Correlate with Treatment State in Thyroid Cancer
Brian W. Kim 

During Active Surveillance of Papillary Thyroid Microcarcinomas Higher Serum TSH Is Associated with Nodule Growth
Jerome M. Hershman 

Patients with Advanced Papillary Thyroid Cancer Have Fewer Recurrences after Undergoing Surgery by High-Volume Surgeons
Masha J. Livhits, Michael W. Yeh 

Extent of Initial Surgery May Impact Overall Survival, Even for Low-Risk Papillary Thyroid Cancers
Tracy S. Wang 

 

The post Clinical Thyroidology^®High-Impact Articles appeared first on American Thyroid Association.

https://ift.tt/2ETS5wR

Primary high-grade calcitonin-negative neuroendocrine carcinoma of the thyroid: a very rare cancer

Summary

Most medullary thyroid carcinomas (MTCs) are low grade and produce calcitonin. There are some calcitonin-negative MTCs that produce only calcitonin gene-related peptide (CGRP). Rarely, MTCs are negative for calcitonin and CGRP peptides, but contain their corresponding mRNAs. Primary thyroid neuroendocrine neoplasms other than MTCs are extremely rare. We describe a primary high-grade neuroendocrine carcinoma that was negative for CGRP and calcitonin at both the protein and mRNA levels. A 42-year-old woman presented with a rapidly enlarging thyroid mass replacing most of the left lobe and isthmus. A computed tomography-guided core-needle biopsy was performed. The tumor was composed of sheets of small-to-medium sized epithelial cells. The cells were immunoreactive for pancytokeratin, synaptophysin, CD56 and thyroid transcription factor-1, but negative for CK7, CK20, CD45, CD99, ERG, chromogranin A, thyroglobulin, calcitonin, CGRP and carcinoembryonic antigen. The Ki-67 proliferation index was ~90%. In situ hybridization was negative for calcitonin mRNA. The patient was initially diagnosed as having a small cell carcinoma. She was treated with cisplatin and etoposide (VP16), followed by radiation therapy. Given the excellent clinical course, the tumor was reviewed and reclassified as a high-grade neuroendocrine carcinoma (non-small-cell type). Heretofore, only a few other similar high-grade neuroendocrine tumors with negative markers of C-cell derivation have been reported. In our case, the patient is cancer free five years after diagnosis, but in the other cases, the outcome was poor.

Learning points:

There are neuroendocrine carcinomas of the thyroid that do not produce calcitonin or calcitonin gene-related peptide.

This category of calcitonin-negative neuroendocrine carcinomas is heterogeneous, consisting of low- and high-grade tumors.

The high-grade neuroendocrine carcinomas of the thyroid are rare and generally have a poor prognosis. They are divided into small cell and non-small cell or large cell types.

https://ift.tt/2H5HLUd

Analysis of asymmetries in air pollution with water resources, and energy consumption in Iran

Abstract

Iran should pay special attention to its excessive consumption of energy and air pollution due to the limited availability of water resources. This study explores the effects of the consumption of energy and water resources on air pollution in Iran from 1971 to 2014. It utilizes the non-linear autoregressive distributed lag approach to establish a robust relationship between the variables which show that both long- and short-run coefficients are asymmetrical. The positive and negative aspects of the long-run coefficients of energy consumption and water resources were found to be 0.19, − 1.63, 0.18, and 2.36, respectively, while only the negative ones were significant for energy consumption. Based on the cumulative effects, it can be established that there are important and significant differences in the responses of air pollution to positive and negative changes in water productivity and energy consumption. In particular, CO₂ gas emissions are affected by negative changes in H₂O productivity both in terms of the total and the GDP per unit of energy use in Iran. In regard to short-run results, considerable asymmetric effects occur on all the variables for CO₂ emissions. Based on the results obtained, some recommendations are presented, which policymakers can adopt in efforts to address the issues of pollution and consumption.

https://ift.tt/2H8IgwW

Impact of antioxidant additives on the performance and emission characteristics of C.I engine fuelled with B20 blend of rice bran biodiesel

Abstract

This manuscript presents the impact of addition of antioxidant additives to rice bran biodiesel blend on the performance and emission characteristics of compression ignition (C.I) engine. Rice bran methyl ester (RBME) was produced from rice bran oil by transesterification using sodium hydroxide as catalyst. An experimental investigation was conducted on a single-cylinder four-stroke C.I engine to analyze the performance and emission characteristics of rice bran methyl ester (RBME) blended with diesel at 20% by volume (B20) with and without addition of 1000 ppm of two monophenolic antioxidant additives, butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). The results showed that the BHA- and BHT-treated B20 blend decreased the brake specific fuel consumption (BSFC) by 2.1 and 1.2% and increased the brake thermal efficiency (BTE) by 1.04 and 0.5% compared to B20. The BHA- and BHT-treated B20 blend produced mean reductions in NOx emission of 12.2 and 9.6%, respectively, compared to B20. The carbon monoxide (CO) and hydrocarbon (HC) emissions of BHA- and BHT-treated B20 were increased by 14.8–16.6% and 10.6–11.2%, respectively, compared to B20. However the emission levels were lower than those of diesel.

https://ift.tt/2qDR73t

Effect of different bulking agents on water variation and thermal balance and their respective contribution to bio-generated heat during long-term storage sludge biodrying process

Abstract

Biodrying was first used for the post-treatment of long-term storage sludge with vinasse as bulking agents. The effect of different bulking agents on water and heat variation and their respective contributions to bio-generated heat during storage sludge biodrying were investigated. Three different bulking agents (beer lees and distillers grains, with conventional straw used for comparison) were mixed with storage sludge for biodrying for an 18-day period. The results revealed the treatment with beer lees as bulking agent achieved the best performance with the highest water removal capacity (658 g kg⁻¹ initial water). The extent of organic degradation in the mixture was related to the degradation ability of the bulking agents. The degradation of C- and H-containing materials (e.g., carboxylic acid) accounted for volatile solids (VS) loss. Water and thermal analyses showed that evaporation was the main way of water loss (accounting for 90%), while evaporation heat was the main component of heat consumption (accounting for 56.67–60.62%).The biodegradation of bulking agents contributed a high proportion of the bio-generated heat consumed by water evaporation (82.35–86.67%).

https://ift.tt/2H926rC

Connecting gastrointestinal cancer risk to cadmium and lead exposure in the Chaoshan population of Southeast China

Abstract

Cadmium (Cd) and lead (Pb) pose a serious threat to human health because of its carcinogenicity. China ranks first according to the Global Cancer Report for 2014 in newly diagnosed gastrointestinal cancers and cancer deaths. The aim of the present study was to evaluate the association of Cd and Pb burden with the risk of gastrointestinal cancers in a hospital-based case-control study from southern regions of China, Chaoshan area. A total of 279 hospitalized patients were recruited in this study, of which 167 were gastrointestinal cancer cases (70 esophageal cancer, 51 gastric cancer, and 46 colorectal cancer), and 112 controls were recruited from two hospitals in the Chaoshan area of southeast China. Basic clinical data and information on gender, age, and other demographic characteristics were collected from medical records. Blood Cd and Pb levels were detected by graphite furnace atomizer absorption spectrophotometry (GFAAS). Blood Cd/Pb levels and over-limit ratios between cases and controls were compared by Mann-Whitney U and Kruskal-Wallis H tests. We used logistic regression to estimate odds ratios (ORs) as measures of relative risk and explored the relationships between blood Cd/Pb levels and gastrointestinal cancer risk and clinicopathological characteristics. Median levels of blood Cd and Pb in cases (2.12 and 60.03 μg/L, respectively) were significantly higher than those of controls (1.47 and 53.84 μg/L, respectively). The over-limit ratios for Cd (≥ 5 μg/L) and Pb (≥ 100 μg/L) in the cases were both higher than that of controls. Blood Cd levels had a tendency to accumulate in the human body with gender, age, and tobacco smoking, while blood Pb levels only were associated with tobacco smoking. The logistic regression model illustrated that gastrointestinal cancers were significantly associated with blood Cd levels and blood Pb levels. The concentrations of Cd and Pb in patients with T3 + T4 stage were markedly higher than in patients with T1 + T2. On the other hand, blood Cd levels were dramatically increased in the distant –metastasis (M1). Blood Cd and Pb levels are significantly higher in gastrointestinal cancers compared to controls. Cd and Pb appear to be risk factors for gastrointestinal cancers in Chaoshan region, and higher levels of Cd and Pb may promote the occurrence and progression of gastrointestinal cancers.

https://ift.tt/2qEi32O

Performance assessment of laboratory and field-scale multi-step passive treatment of iron-rich acid mine drainage for design improvement

Abstract

Multi-step passive systems for the treatment of iron-rich acid mine drainage (Fe-rich AMD) perform satisfactorily at the laboratory scale. However, their field-scale application has revealed dissimilarities in performance, particularly with respect to hydraulic parameters. In this study, the assessment of factors potentially responsible for the variations in performance of laboratory and field-scale multi-step systems was undertaken. Three laboratory multi-step treatment scenarios, involving a combination of dispersed alkaline substrate (DAS) units, anoxic dolomitic drains, and passive biochemical reactors (PBRs), were set up in 10.7-L columns. The field-scale treatment consisted of two PBRs separated by a wood ash (WA) reactor. The parameters identified as possibly influencing the performances of the laboratory and field-scale experiments were the following: AMD chemistry (electrical conductivity and Fe and SO₄²⁻ concentrations), flow rate (Q), and saturated hydraulic conductivity (k_sat). Based on these findings, the design of an efficient passive multi-step treatment system is suggested to consider the following: (1) Fe pretreatment, using materials with high k_sat and low HRT. If a PBR is to be used, the Fe load should be < 26 g/m³ substrate/day (Fe < 200 mg/L) and SO₄²⁻ < 110 g/m³ substrate/day; (2) PBR/DAS filled with a mixture with at least 20% of neutralizing agent; (3) include Q and k_sat (> 10⁻³ cm/s) in the long-term prediction. Finally, mesocosm testing is strongly recommended prior to construction of full-scale systems for the treatment of Fe-rich AMD.

https://ift.tt/2J30NLq

Sedimentary chronology reinterpreted from Changshou Lake of the Three Gorges Reservoir Area reveals natural and anthropogenic controls on sediment production

Abstract

Sedimentary archives preserved in geomorphic sinks provide records of historical sediment dynamics and its related natural and anthropogenic controls. This study reinterpreted sedimentary processes in Changshou Lake of the Three Gorges Reservoir Area in China by combining a rainfall erosivity index with multiple tracing proxies, and the impacts of natural and anthropogenic drivers on sediment production were also explored. Erosive rainfalls with low frequency and large magnitude in the rainy season contribute to a substantial proportion of annual total rainfall, which thus can be used to infer erosion and sediment yield events. The sedimentary chronology was determined by comparing rainfall erosivity index with depth distribution of ¹³⁷Cs and absolute particle size, which revealed annual sedimentation rates ranging from 1.1 to 2.3 cm a⁻¹. The multi-proxy dating index and variation of sedimentation rate divided the sediment profile into three major periods. The reference period (1956–1982) displays low variability of TOC, TN, trace metal concentrations, and mean sedimentation rate. In the stressed period (1982–1998), industrial and sewerage discharge led to input and deposition of TOC, TN, and trace metals (e.g., Cd, Co, Cu, Cr, and Ni). The highest annual sediment accumulation rate of 2.3 cm a⁻¹ may be ascribed to the 1982 big flood event. In the present period (1998–2013), increased TOC, TN and decreased trace metals in the top layers of the sediment core indicated changes in lake ecology. Fish farming promoted algal growth and primary productivity which caused eutrophication until 2004–2005. The reduced mean sedimentation rate of 1.7 cm a⁻¹ between 1998 and 2004, and thereafter, may be attributed to soil and water conservation and reforestation policies implemented in the Longxi catchment. Human activities such as deforestation, cultural and industrial revolution, and lake eutrophication associated with fish farming since 1989, therefore led to appreciable limnological variations. Overall, the dated sedimentary profile from Changshou Lake displays high consistency with archived historical events and reflects the impact of both natural and anthropogenic controls on sediment production.

https://ift.tt/2qCPumi

Scholar : These new articles for Dynamics of Asymmetric Conflict are available online

The online platform for Taylor & Francis Online content New for Dynamics of Asymmetric Conflict and online now on Taylor & Francis Online: Original Articles Grandstanding or foreshadowing: analysing the University of Alabama active shooter threats with intergroup threat theory Michael J. Egnoto, Darrin J. Griffin & Fei Qiao Pages: 1-15 | DOI: 10.1080/17467586.2018.1432867 2018 Future Directions Forum JOIN US at the 2018 Future Directions Forum for Journal of Clinical Child & Adolescent Psychology - June 15-16, 2018 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Real-motion signals in human early visual cortex

Publication date: 15 July 2018
Source:NeuroImage, Volume 175
Author(s): Matthias Nau, Andreas Schindler, Andreas Bartels
Eye movements induce visual motion that can complicate the stable perception of the world. The visual system compensates for such self-induced visual motion by integrating visual input with efference copies of eye movement commands. This mechanism is central as it does not only support perceptual stability but also mediates reliable perception of world-centered objective motion. In humans, it remains elusive whether visual motion responses in early retinotopic cortex are driven by objective motion or by retinal motion associated with it. To address this question, we used fMRI to examine functional responses of sixteen visual areas to combinations of planar objective motion and pursuit eye movements. Observers were exposed to objective motion that was faster, matched or slower relative to pursuit, allowing us to compare conditions that differed in objective motion velocity while retinal motion and eye movement signals were matched. Our results show that not only higher level motion regions such as V3A and V6, but also early visual areas signaled the velocity of objective motion, hence the product of integrating retinal with non-retinal signals. These results shed new light on mechanisms that mediate perceptual stability and real-motion perception, and show that extra-retinal signals related to pursuit eye movements influence processing in human early visual cortex.



https://ift.tt/2qEEiVF

Noninvasive stimulation of the ventromedial prefrontal cortex modulates emotional face processing

Publication date: 15 July 2018
Source:NeuroImage, Volume 175
Author(s): Constantin Winker, Maimu A. Rehbein, Dean Sabatinelli, Mira Dohn, Julius Maitzen, Carsten H. Wolters, Volker Arolt, Markus Junghofer
The ventromedial prefrontal cortex (vmPFC) is associated with emotional states that can be characterized as positive affect. Moreover, a variety of psychiatric disorders that are associated with disturbed reactions toward reward- or safety-signaling stimuli reveal functional or structural anomalies within this area. Thus, neuromodulation of this region via transcranial direct current stimulation (tDCS) offers an attractive opportunity to noninvasively influence pleasant emotional and reward processing. Recent experiments revealed hemodynamic and electrophysiological evidence for valence specific modulations of emotional scene processing after excitatory and inhibitory tDCS of the vmPFC. Here, we identified that tDCS modulation of vmPFC during emotional face processing results in effects convergent with scene processing, in that excitatory tDCS increased neural reactivity during happy compared to fearful face perception, whereas inhibitory stimulation led to a converse effect. In addition, behavioral data (affect identification of ambiguous expressive faces) revealed a bias toward preferential processing of happy compared to fearful faces after excitatory compared to after inhibitory stimulation. These results further support the vmPFC as an appropriate target for noninvasive neuromodulation of an appetitive processing network in patients suffering from disturbed cognition of reward- and safety-signaling stimuli. It should however be noted that electrophysiological pre-tDCS differences at earlier time intervals of emotional face and scene processing appeared amplified by tDCS, which remains to be investigated.



https://ift.tt/2H7rB0K

Scholar : These new articles for Aphasiology are available online

The online platform for Taylor & Francis Online content New for Aphasiology and online now on Taylor & Francis Online: Original Articles Use of co-verbal gestures during word-finding difficulty among Cantonese speakers with fluent aphasia and unimpaired controls Anthony Pak-Hin Kong, Sam-Po Law & Charis Ka-Yan Cheung Pages: 1-18 | DOI: 10.1080/02687038.2018.1463085 2018 Future Directions Forum JOIN US at the 2018 Future Directions Forum for Journal of Clinical Child & Adolescent Psychology - June 15-16, 2018 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Scholar : Journal of Museum Education, Volume 43, Issue 2, June 2018 is now available online on Taylor & Francis Online

The online platform for Taylor & Francis Online content Journal of Museum Education, Volume 43, Issue 2, June 2018 is now available online on Taylor & Francis Online. Rebuilding Civil Civics in Museums This new issue contains the following articles: Editorial From the Editor-in-Chief Cynthia Robinson Pages: 83-84 | DOI: 10.1080/10598650.2018.1458416 From the Guest Editor Rebuilding Civil Civics in Museums Caroline Angel Burke Pages: 85-90 | DOI: 10.1080/10598650.2018.1457900 Public History Institutions: Leaders in Civics Through the Power of the Past Kathleen Munn & K. Allison Wickens Pages: 91-103 | DOI: 10.1080/10598650.2018.1453598 Targeting Truth: How Museums Can Collaboratively Address Social Issues Theresa M. de los Santos, Elizabeth Smith & Mira Cohen Pages: 104-113 | DOI: 10.1080/10598650.2018.1457842 Using Storytelling to Establish Justice: How Civic Education Can Change Police Community Relations Kerry Sautner & Gregorio Medina Pages: 114-125 | DOI: 10.1080/10598650.2018.1454734 Museums as Vital Resources for New Americans: The Citizenship Project Mia Nagawiecki Pages: 126-136 | DOI: 10.1080/10598650.2018.1455462 Rooted in the Past, Active for the Future: Museums and Inspiring a New Generation of Citizens Braden Paynter, Carola Zuleta, Daniel Rebolledo, Karen Bascuñán, Lebogang Marishane & Mohamed El Khamlichi Pages: 137-147 | DOI: 10.1080/10598650.2018.1457320 What the Research Says Visual Literacy and Its Impact on Pre-literacy Development Mike Deetsch, Rachel Glass, Regina Jankowski, Evelyn Mylander, Peggy Roth & Elisabeth Wharton Pages: 148-158 | DOI: 10.1080/10598650.2018.1426332 Mediating Museum Display and Technology: A Case Study of an International Exhibition Incorporating QR Codes Virginia A. Dressler & Koon-Hwee Kan Pages: 159-170 | DOI: 10.1080/10598650.2018.1459081 To update which email alerts you receive, manage your alerts within the My Account area. Unsubscribe from new content alerts for this journal (both new issue and latest article notifications) with one click. If you need any further help, please contact us at support@tandfonline.com Please do not reply to this email. To ensure that you receive your alerts and information from Taylor & Francis Online, please add "alerts@tandfonline.com" and "info@tandfonline.com" to your safe senders list. Taylor & Francis, an Informa business. Taylor & Francis is a trading name of Informa UK Limited, registered in England under no. 1072954. Registered office: 5 Howick Place, London, SW1P 1WG.

Successful neoadjuvant peptide receptor radionuclide therapy for an inoperable pancreatic neuroendocrine tumour

Summary

Non-functional pancreatic neuroendocrine tumours (NETs) can present with advanced local or distant (metastatic) disease limiting the possibility of surgical cure. Several treatment options have been used in experimental neoadjuvant settings to improve the outcomes in such cases. Peptide receptor radionuclide therapy (PPRT) using beta emitting radiolabelled somatostatin analogues has been used in progressive pancreatic NETs. We report a 55-year-old female patient with a 12.8 cm pancreatic NET with significant local stomach and superior mesenteric vein compression and liver metastases. The patient underwent treatment with [¹⁷⁷Lutetium-DOTA^0,Tyr³]octreotate (¹⁷⁷Lu-octreotate) for the treatment of local and metastatic symptomatic disease. Six months after 4 cycles of ¹⁷⁷lutetium-octreotate, resolution of the abdominal complaints was associated with a significant reduction in tumour size and the tumour was rendered operable. Histology of the tumour showed a 90% necrotic tumour with abundant hyalinized fibrosis and haemorrhage compatible with PPRT-induced radiation effects on tumour cells. This report supports that PPRT has a role in unresectable and metastatic pancreatic NET.

Learning points:

PRRT with ¹⁷⁷Lu-octreotate can be considered a useful therapy for symptomatic somatostatin receptor-positive pancreatic NET.

The clinical benefits of PRRT with ¹⁷⁷Lu-octreotate can be seen in the first months while tumour reduction can be seen up to a year after treatment.

PRRT with ¹⁷⁷Lu-octreotate was clinically well tolerated and did not interfere with the subsequent surgical procedure.

PRRT with ¹⁷⁷Lu-octreotate can result in significant tumour reduction and may improve surgical outcomes. As such, this therapy can be considered as a neoadjuvant therapy.

https://ift.tt/2ETPGSF

TBK1: A key regulator and potential treatment target for interferon positive Sjögren's syndrome, systemic lupus erythematosus and systemic sclerosis

Publication date: Available online 16 April 2018
Source:Journal of Autoimmunity
Author(s): Iris L.A. Bodewes, Erika Huijser, Cornelia G. van Helden-Meeuwsen, Liselotte Tas, Ruth Huizinga, Virgil A.S.H. Dalm, P. Martin van Hagen, Noortje Groot, Sylvia Kamphuis, Paul L.A. van Daele, Marjan A. Versnel
ObjectiveUpregulation of type I interferons (IFN-I) is a hallmark of systemic autoimmune diseases like primary Sjögren's syndrome (pSS), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc). Expression of IFN-I is induced by three different receptor families: Toll-like receptors (TLRs), RIG-like receptors (RLRs) and DNA-sensing receptors (DSRs). TANK-binding kinase (TBK1) is an important signaling hub downstream of RLRs and DSRs. TBK1 activates IRF3 and IRF7, leading to IFN-I production and subsequent induction of interferon stimulated genes (ISGs). The objective of this study was to explore the potential of BX795, an inhibitor of TBK1, to downregulate IFN-I activation in pSS, SLE and SSc.MethodsTBK1, IRF3, IRF7 and STAT1 were determined by RT-PCR in PAXgene samples and phosphorylated-TBK1 (pTBK1) was analyzed by flowcytometry in plasmacytoid dendritic cells (pDCs) from IFN-I positive (IFNpos) patients. Peripheral blood mononuclear cells (PBMCs) of pSS, SLE and SSc patients and TLR7 stimulated PBMCs of healthy controls (HCs) were cultured with the TBK1 inhibitor BX795, followed by analysis of ISGs.ResultsIncreased gene expression of TBK1, IRF3, IRF7 and STAT1 in whole blood and pTBK1 in pDCs was observed in IFNpos pSS, SLE and SSc patients compared to HCs. Upon treatment with BX795, PBMCs from IFNpos pSS, SLE, SSc and TLR7-stimulated HCs downregulated the expression of the ISGs MxA, IFI44, IFI44L, IFIT1 and IFIT3.ConclusionsTBK1 inhibition reduced expression of ISGs in PBMCs from IFNpos patients with systemic autoimmune diseases indicating TBK1 as a potential treatment target.



https://ift.tt/2J22p8c

Effectiveness and Safety of Bronchial Thermoplasty in Management of Asthma [Internet].

This review assesses the effectiveness and safety of bronchial thermoplasty (BT) in adults with asthma.

https://ift.tt/2JTkHcX