Clustered structural and functional plasticity of dendritic spines

Publication date: Available online 13 September 2016
Source:Brain Research Bulletin
Author(s): Ju Lu, Yi Zuo
The configuration of synaptic circuits underlies their ability to process and store information. Research on dendritic spines has revealed that their structural and functional alterations are clustered along the parent dendrite. Here we review the evidence supporting such notion of clustered synaptic plasticity, discuss its functional implications and possible contributing factors, and suggest potential strategies to deal with open challenges.



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