Feasibility of Periodontal Tissue Regeneration Therapy with Adipose-Derived Stem Cells

Abstract

Adipose-derived stem cells within subcutaneous adipose tissue were first reported in 2001. Since then, the number of regenerative medicine studies investigating adipose-derived stem cells (ASCs) has increased dramatically. This has included not only basic research in regenerative medicine using ASCs but also has progressed and clinical safety studies have now commenced in Japan. Translational research (including clinical research and clinical trials) using cell therapy aims to verify the possibility of achieving repair of tissue or its function and investigating the safety of these protocols. However, despite this simplicity, elucidating the mechanism of action of implanted processed cells is difficult. This indicates the necessity for the further discussion focusing on translational research for cell therapy, as well as continuing to develop novel therapeutic strategies. In this paper, we discuss the feasibility of practical application of using ASCs for periodontal tissue regeneration therapy and discuss the legal system for promoting the practical application of regenerative medicine recently enforced in Japan.

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