Feed My Heart or Eat It miR-22 Decides ∗

If we live well, eat right, do not smoke, and by so doing avoid the usual diseases that end life prematurely, we will get old. More of us are doing so every year. Thus, for selfish and scientific reasons, the physical, biochemical, and molecular changes provoked by aging merit attention. A revolution in our understanding of how noncoding ribonucleic acid (RNA) species regulate cardiovascular function in health and disease makes the intersection between microribonucleic acid (miRNA) biology and aging fertile ground for investigation. In this issue of the Journal, Gupta et al. (1) described a miRNA that is increased in aging and suppresses a process whose dysfunction is postulated to contribute to aging phenotypes, autophagy.

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