Hypertranscription in Development, Stem Cells, and Regeneration

Publication date: Available online 15 December 2016
Source:Developmental Cell
Author(s): Michelle Percharde, Aydan Bulut-Karslioglu, Miguel Ramalho-Santos
Cells can globally upregulate their transcriptome during specific transitions, a phenomenon called hypertranscription. Evidence for hypertranscription dates back over 70 years but has gone largely ignored in the genomics era until recently. We discuss data supporting the notion that hypertranscription is a unifying theme in embryonic development, stem cell biology, regeneration, and cell competition. We review the history, methods for analysis, underlying mechanisms, and biological significance of hypertranscription.

Teaser

Cells can globally upregulate their transcriptome during specific transitions, a phenomenon called hypertranscription. Hypertranscription has gone largely ignored in the genomics era until recently. Percharde et al. discuss hypertranscription as a unifying theme in embryonic development, stem cell biology, regeneration, and cell competition, along with methods for its accurate analysis.


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