Major infections, secondary cancers and autoimmune diseases occur in different clinical subsets of chronic lymphocytic leukaemia patients

Publication date: February 2017
Source:European Journal of Cancer, Volume 72
Author(s): Andrea Visentin, Silvia Imbergamo, Carmela Gurrieri, Federica Frezzato, Valentina Trimarco, Veronica Martini, Filippo Severin, Flavia Raggi, Edoardo Scomazzon, Monica Facco, Francesco Piazza, Gianpietro Semenzato, Livio Trentin
BackgroundMajor infections (MIs), secondary cancers (SCs) and autoimmune diseases (ADs) are the most common and relevant complications in patients with chronic lymphocytic leukaemia.MethodsWe performed a single-centre retrospective study to investigate the prevalence of the above quoted complications, the association with most important prognostic markers and their impact on survival (n = 795).ResultsAlmost one out of three patients experienced at least one complication and only 0.9% of the cohort developed all three complications. One hundred and twenty (20%) subjects developed SC, 98 MI (12%) and 80 AD (10%); these complications seem to occur in a mutually exclusive manner. By Kaplan–Meier analysis we estimated that after 20 years from the diagnosis SC, MI and AD occurred in 48%, 42% and 29% of patients, respectively. Furthermore, we showed that some clinical and biological markers are skewed among patients with different complications and that subjects with MI and SC had a worse prognosis than those with AD and all other patients (p < 0.0001).ConclusionsThis study reveals the existence of different clinical subsets of chronic lymphocytic leukaemia patients characterised by an increased and different risk for developing specifically MI, SC and AD.



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