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Παρασκευή 30 Δεκεμβρίου 2016

Novel four-sided neural probe fabricated by a thermal lamination process of polymer films

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Publication date: Available online 29 December 2016
Source:Journal of Neuroscience Methods
Author(s): Soowon Shin, Jae-Hyun Kim, Joonsoo Jeong, Tae Mok Gwon, Seung-Hee Lee, Sung June Kim
BackgroundIdeally, neural probes should have channels with a three-dimensional (3-D) configuration to record the activities of 3-D neural circuits. Many types of 3-D neural probes have been developed; however, most of them were designed as an array of multiple shanks with electrodes located along one side of the shanks.New methodWe developed a novel liquid crystal polymer (LCP)-based neural probe with four-sided electrodes. This probe has electrodes on four sides of the shank, i.e., the front, back and two sidewalls. To generate the proposed configuration of the electrodes, we used a thermal lamination process involving LCP films and laser micromachining.ResultsThe proposed novel four-sided neural probe, was used to successfully perform in vivo multichannel neural recording in the mouse primary somatosensory cortex.Comparison with existing methodThe multichannel neural recording showed that the proposed four-sided neural probe can record spiking activities from a more diverse neuronal population than single-sided probes. This was confirmed by a pairwise Pearson correlation coefficient (Pearson's r) analysis and a cross-correlation analysis.ConclusionThe developed four-sided neural probe can be used to record various signals from a complex neural network.



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