Aripiprazole (Abilify): Depression, Major Depressive Disorder (MDD) [Internet].

Major depressive disorder (MDD) is characterized by the occurrence of one or more major depressive episodes (MDEs), which persist for at least two weeks and are characterized by a depressed mood and/or markedly diminished interest or pleasure in all, or almost all, activities. The clinical manifestation of MDD is heterogeneous. The duration of MDEs can also vary significantly in duration, ranging from weeks to years. MDD is one of the most prevalent chronic conditions in Canada, with an annual prevalence reaching 4.8% and a lifetime prevalence of 10.8% of the population. The prevalence of MDD is twice as high for women as for men, but this difference declines with age. According to the Global Burden of Disease Study and other studies, MDD is a major cause of disability. Because of its early age of onset and frequent recurrences, MDD is also among the leading causes of disability, as measured by disability-adjusted life-years, worldwide.

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