Cross-sectional evaluation of acute adverse reactions during UVA1 phototherapy

Abstract

Phototherapy with ultraviolet A-1 (UVA1) can induce durable remissions in sclerosing disorders such as morphea¹. Optimal UVA1 dosing remains an area of research^2-4. Acute adverse reactions to UVA1 include erythema, pruritus and polymorphic light eruption (PMLE)⁵. The acute adverse reaction rate during UVA1 phototherapy has been reported to be as high as 15%, half of which was attributable to erythema⁶. However, other articles report minimal acute UVA1 toxicity⁷. Our objectives were to report on the chronology of acute adverse reactions and to identify associated factors.

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