Kidney Stone Nano-Structure – Is there an Opportunity for Nanomedicine Development?

Publication date: Available online 24 January 2017
Source:Biochimica et Biophysica Acta (BBA) - General Subjects
Author(s): N. Vordos, S. Giannakopoulos, D.A. Gkika, J.W. Nolan, Ch. Kalaitzis, D.V. Bandekas, C. Kontogoulidou, A.Ch. Mitropoulos, S. Touloupidis
BackgroundKidney stone analysis techniques are well established in the field of materials characterization and provide information for the chemical composition and structure of a sample. Nanomedicine, on the other hand, is a field with an increasing rate of scientific research, a big budget and increasingly developing market. The key scientific question is if there is a possibility for the development of a nanomedicine to treat kidney stones.Major ConclusionsThe main calculi characterization techniques such as X – Ray Diffraction and Fourier Transform Infrared Spectroscopy can provide information about the composition of a kidney stone but not for its nanostructure. On the other hand, Small Angle X – Ray Scattering and Nitrogen Porosimetry can show the nanostructural parameters of the calculi. The combination of the previously described parameters can be used for the development of nano - drugs for the treatment of Urolithiasis, while no such nano-drugs exist yet.General SignificanceIn this study, we focus on the most well-known techniques for kidney stone analysis, the urolithiasis management and the search for possible nanomedicine for the treatment of kidney stone disease. We combine the results from five different analysis techniques in order to represent a three dimensional model and we propose a hypothetical nano-drug with gold nanoparticles.



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