One-step enzymatic synthesis of poly(p-dioxanone-co-butylene-co-succinate) copolyesters with well-defined structure and enhanced degradability

Publication date: 24 February 2017
Source:Polymer, Volume 111
Author(s): Wu-Cheng Nie, Hai-Chun Dang, Xiu-Li Wang, Fei Song, Yu-Zhong Wang
In this work, we present a mild one-step enzymatic-catalyzed copolymerization of diethyl succinate, 1,4-butanediol and p-dioxanone (PDO) to synthesize poly(p-dioxanone-co-butylene-co-succinate) copolyesters. Their chemical structure, triad distributions, and molecular weight of the copolyesters are characterized by ¹H NMR, ¹³C NMR and GPC. All copolyesters have narrow molecular weight polydispersity (1.3–1.5) and higher molecular weight (Mw) values (23700–33200 g mol⁻¹), which are well controlled by varying the amount of PDO units from 9 to 30 mol%. NMR, DSC, and XRD results show that copolyesters are semicrystalline random copolyesters and thermal properties depended on their composition. Furthermore, the degradation rate of the poly(p-dioxanone-co-butylene-co-succinate) are enhanced compared to PBS.

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