Tissue engineering by decellularization and 3D bioprinting

Publication date: Available online 19 January 2017
Source:Materials Today
Author(s): Elena Garreta, Roger Oria, Carolina Tarantino, Mateu Pla-Roca, Patricia Prado, Francisco Fernández-Avilés, Josep Maria Campistol, Josep Samitier, Nuria Montserrat
Discarded human donor organs have been shown to provide decellularized extracellular matrix (dECM) scaffolds suitable for organ engineering. The quest for appropriate cell sources to satisfy the need of multiple cells types in order to fully repopulate human organ-derived dECM scaffolds has opened new venues for the use of human pluripotent stem cells (hPSCs) for recellularization. In addition, three-dimensional (3D) bioprinting techniques are advancing towards the fabrication of biomimetic cell-laden biomaterial constructs. Here, we review recent progress in decellularization/recellularization and 3D bioprinting technologies, aiming to fabricate autologous tissue grafts and organs with an impact in regenerative medicine.



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