IL-1β directly suppress ghrelin mRNA expression in ghrelin-producing cells

Publication date: Available online 22 February 2017
Source:Molecular and Cellular Endocrinology
Author(s): Mika Bando, Hiroshi Iwakura, Yoko Ueda, Hiroyuki Ariyasu, Hidefumi Inaba, Yasushi Furukawa, Hiroto Furuta, Masahiro Nishi, Takashi Akamizu
In animal models, ghrelin production is suppressed by LPS administration. To elucidate the detailed molecular mechanisms involved in the phenomenon, we investigated the effects of LPS and LPS-inducible cytokines, including TNF-α, IL-1β, and IL-6, on the expression of ghrelin in the ghrelin-producing cell line MGN3-1. These cells expressed IL-1R, and IL-1β significantly suppressed ghrelin mRNA levels. The suppressive effects of IL-1β were attenuated by knockdown of IKKβ, suggesting the involvement of the NF-κB pathway. These results suggested that IL-1β is a major regulator of ghrelin expression during inflammatory processes.



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