Brain source localization of MMN and P300 ERPs in Mild Cognitive Impairment and Alzheimer's disease: A High-Density EEG approach

Publication date: Available online 29 March 2017
Source:Neurobiology of Aging
Author(s): Anthoula C. Tsolaki, Vasiliki Kosmidou, Ioannis (Yiannis) Kompatsiaris, Chrysa Papadaniil, Leontios Hadjileontiadis, Aikaterini Adam, Magda Tsolaki
Alzheimer's disease is the most common neurodegenerative disease of western societies, suggesting the need for early diagnosis, even in preclinical stages. In this vein, the localization of neuronal generators of Event-Related Potential (ERP) components, i.e., the MMN and the P300, based on high-density (HD)-EEG data, was explored as a means to enhance their sensitivity as markers of preclinical AD. A two-tone oddball experiment was conducted, involving 21 healthy elderlies, 21 mild cognitive impairment (MCI) and 21 mild AD patients, while HD-EEG data were recorded. The results revealed longer latencies of both mismatch negativity (MMN) and P300 and slower and far less accurate responses as neurodegeneration progressed. sLORETA revealed that source differences between healthy and MCI and healthy and AD patients for both ERP components were present in the same Brodmann Area (BA) independently of the ERP and the stage of cognitive decline. This finding indicates an early change of source activation related to cognitive performance and may be used to improve the diagnostic and prognostic value of ERPs.



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