Disentangling a Bad Reputation: Changing Perceptions of Amyloids

Publication date: Available online 27 March 2017
Source:Trends in Cell Biology
Author(s): Miling Wang, Timothy E. Audas, Stephen Lee
Historically, amyloids were perceived as toxic/irreversible protein aggregates associated with neurodegenerative disorders including Alzheimer's and Parkinson's diseases. Recent papers are challenging this perception by uncovering widespread cellular roles for physiological amyloidogenesis. These findings suggest that the amyloid-fold should be considered, alongside the native-fold and unfolded configurations, as a physiological and reversible protein organization.



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