Increase of circulating α4β7+ conventional memory CD4 and regulatory T cells in patients with common variable immunodeficiency (CVID)

Publication date: Available online 18 March 2017
Source:Clinical Immunology
Author(s): Karina Mescouto de Melo, Susanne Unger, Baerbel Keller, Sylvia Gutenberger, Ina Stumpf, Sigune Goldacker, Klaus Warnatz
This study investigated whether circulating α4β7⁺ expressing T cells could serve as a potential marker for gastrointestinal (GI) disease activity in patients with CVID. The analysis of α4β7⁺ T cells in the peripheral blood of 36 patients and 22 healthy donors (HD) revealed increased percentages of α4β7⁺ conventional memory CD4 T cells and Tregs, but not among CD8 T-cell populations in patients with CVID compared to HD. No differences between patients with and without chronic or acute GI symptoms were observed. EUROClass smB− and 21lo patients, had higher percentages of α4β7⁺ memory CD4 T cells compared to HD and smB+ or 21norm patients, respectively. In summary, the detection of α4β7⁺ T cells in the peripheral blood did not correlate with active or chronic gastrointestinal disease. The increase of these cells in smB− and 21lo patients adds another piece to the immune dysregulation observed in these patients.



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