Source:The Journal of Prosthetic Dentistry
Author(s): Yogesh Kumar, Veena Jain, Shyam Singh Chauhan, Vinayak Bharate, Dheeraj Koli, Manish Kumar
Statement of problemIt is unclear how pathogenic bacteria adhere to different implant materials and whether biomarker matrix metalloproteinase-8 (MMP-8) level provides a reliable method of evaluating the connective tissue status of periimplant tissues.PurposeThe purpose of this pilot clinical study was to evaluate periimplant connective tissue response by assessing the MMP-8 levels in periimplant crevicular fluid around titanium and zirconia abutments.Material and methodsThe study was designed as a prospective, within-subject comparison with left-right randomization low. Twelve participants with partial edentulism were selected according to inclusion and exclusion criteria. Periimplant sulcal fluid sampling and pocket probing depths were assessed at 1, 3, and 12 months after placing the abutments. The MMP-8 protein level of the periimplant sulcal fluid was determined by MMP-8-specific sandwich enzyme-linked immunosorbent assay system. The independent t test or Wilcoxon test was used to compare MMP-8 levels and probing depth assessment between the zirconia and titanium groups at different time points (1, 3, and 12 months). Repeated measures ANOVA was used for within-group comparison of the MMP-8 levels at 3 time points (α=.05).ResultsAt 1 and 3 months, the titanium abutments showed significantly higher MMP-8 levels and probing depths than the zirconia abutments (P<.05), but no significant differences were found at 12 months for either variable (P>.05).ConclusionsThis study suggests the presence of more remodeling and/or inflammatory phenomena around titanium implant abutments than around zirconia abutments of a different design during the early stages but not at 1 year.
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