Kawasaki disease and immunisation: A systematic review

Publication date: Available online 2 March 2017
Source:Vaccine
Author(s): Linny Kimly Phuong, Caterina Bonetto, Jim Buttery, Yolanda Brauchli Pernus, Rebecca Chandler, Patrizia Felicetti, Karen L. Goldenthal, Merita Kucuku, Giuseppe Monaco, Barbara Pahud, Stanford T. Shulman, Karina A. Top, Francesco Trotta, Rolando Ulloa-Gutierrez, Frederick Varricchio, Sarah de Ferranti, Jane W. Newburger, Nagib Dahdah, Surjit Singh, Jan Bonhoeffer, David Burgner
BackgroundKawasaki disease is a complex and potentially serious condition. It has been observed in temporal relation to immunisation.MethodsWe conducted a systematic literature review using various reference sources to review the available evidence published in the literature.ResultsWe identified twenty seven publications reporting a temporal association between immunisation and Kawasaki disease. We present a systematic review of data drawn from randomised controlled trials, observational studies, case series and reports, and reviews. Overall there was a lack of standardised case definitions, making data interpretation and comparability challenging.ConclusionsAlthough a temporal relationship between immunisation and Kawasaki disease is suggested, evidence for an increased risk or a causal association is lacking. Implementation of a standardised Kawasaki disease case definition would increase confidence in the findings and add value to future studies of pre- or post-licensure vaccine safety studies.



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