Unveiling the Role of Senescence-Induced Cellular Plasticity

Publication date: 2 March 2017
Source:Cell Stem Cell, Volume 20, Issue 3
Author(s): Jumpei Taguchi, Yasuhiro Yamada
Mice expressing Yamanaka factors develop teratomas containing iPSCs, suggesting that somatic cells are reprogrammable in vivo. Recent studies in Cell, Science, and this issue of Cell Stem Cell (Ocampo et al., 2016; Mosteiro et al., 2016; Chiche et al., 2017, respectively) report crosstalk between reprogramming and senescence, providing insights on cellular plasticity in multicellular organisms.

Teaser

Mice expressing Yamanaka factors develop teratomas containing iPSCs, suggesting that somatic cells are reprogrammable in vivo. Recent studies in Cell, Science, and this issue of Cell Stem Cell (Ocampo et al., 2016; Mosteiro et al., 2016; Chiche et al., 2016, respectively) report crosstalk between reprogramming and senescence, providing insights on cellular plasticity in multicellular organisms.


http://ift.tt/2m0OkiW