Management of Anaplastic Large Cell Lymphoma

Publication date: April 2017
Source:Hematology/Oncology Clinics of North America, Volume 31, Issue 2
Author(s): Dai Chihara, Michelle A. Fanale

Teaser

Anaplastic large cell lymphoma (ALCL) is one of the most common peripheral T-cell lymphomas, and the incidence is higher in blacks than non-Hispanic whites. ALK-positive and ALK-negative ALCL are distinct subtypes that have different characteristics and clinical outcomes. Breast implant–associated ALCL is a rare lymphoma that has a good survival outcome, and a recent study showed that total capsulectomy is essential for treatment. Brentuximab vedotin (BV) is a standard treatment for relapsed/refractory ALCL. The response rate is high at 80–90%; however, once the disease progresses in patients on BV, survival outcome is very poor, with a median overall survival of less than two months.


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