The regulation and role of carbohydrate response element binding protein in metabolic homeostasis and disease

Abstract

The transcription factor carbohydrate response element binding protein (ChREBP) is a member of the basic helix-loop-helix leucine zipper transcription factor family. In high-glucose conditions, it has a role in regulating the expression of key genes involved in various pathways including glycolysis, gluconeogenesis and lipogenesis. It does this by forming a tetrameric complex made up of two ChREBP/Mlx heterodimers, which enables it to bind to the carbohydrate response element (ChoRE) in the promoter region of its target genes to regulate transcription. As ChREBP plays a key role in glucose signaling and metabolism, and aberrations in glucose homeostasis are often present in metabolic diseases, this transcription factor presents itself as an enticing target to further understand metabolic disease mechanisms and potentially uncover new therapeutic targets.

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