Diversity in AMPAR complexes in the brain

Publication date: August 2017
Source:Current Opinion in Neurobiology, Volume 45
Author(s): Eric Jacobi, Jakob von Engelhardt
AMPA receptor (AMPAR) complexes comprise four of the AMPAR subunits GluA1-4 and several additional interacting proteins. Subunit composition determines AMPAR function. However, AMPAR function depends to a large extent also on interacting proteins, which influence trafficking to the cell surface, activity-dependent subcellular localization and gating of AMPARs. In this review we report about recent findings on the diversity of AMPAR complexes that allow us to better understand functional properties of native receptors in the brain.



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