Metabolic reprograming of anti-tumor immunity

Publication date: June 2017
Source:Current Opinion in Immunology, Volume 46
Author(s): Madhusudhanan Sukumar, Rigel J Kishton, Nicholas P Restifo
Immunotherapies designed to trigger T cell destruction of tumor cells can result in sustained and complete responses in patients whose cancers were resistant to available treatment options. Evidence suggests that powering the T cell response – how T cells generate energy – plays an important role in their effectiveness. Furthermore the metabolism of T cells can be modulated to improve their anti-cancer activities. In this review, we will discuss the key metabolic properties of anti-cancer T cells, along with potential strategies to enhance immunotherapy through the modulation of T cell metabolism.



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