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Πέμπτη 13 Απριλίου 2017

The Gut Microbiome: Connecting Spatial Organization to Function

Publication date: 12 April 2017
Source:Cell Host & Microbe, Volume 21, Issue 4
Author(s): Carolina Tropini, Kristen A. Earle, Kerwyn Casey Huang, Justin L. Sonnenburg
The first rudimentary evidence that the human body harbors a microbiota hinted at the complexity of host-associated microbial ecosystems. Now, almost 400 years later, a renaissance in the study of microbiota spatial organization, driven by coincident revolutions in imaging and sequencing technologies, is revealing functional relationships between biogeography and health, particularly in the vertebrate gut. In this Review, we present our current understanding of principles governing the localization of intestinal bacteria, and spatial relationships between bacteria and their hosts. We further discuss important emerging directions that will enable progressing from the inherently descriptive nature of localization and -omics technologies to provide functional, quantitative, and mechanistic insight into this complex ecosystem.

Teaser

Tropini et al. review our understanding of the principles governing the localization of the gut microbiota, and spatial relationships between bacteria and their hosts. They also discuss emerging directions that will enable progressing from the descriptive nature of localization to providing functional, quantitative, and mechanistic insight into this complex ecosystem.


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