A comparative study of chromatographic behavior and lipophilicity of selected natural styryl lactones, their derivatives and analogues

Publication date: Available online 6 May 2017
Source:European Journal of Pharmaceutical Sciences
Author(s): Milica Ž. Karadžić, Davor M. Lončar, Goran Benedeković, Ivana Kovačević, Velimir Popsavin, Strahinja Z. Kovačević, Lidija R. Jevrić, Sanja O. Podunavac-Kuzmanović
This study is based on the analyses of the retention behavior of selected natural styryl lactones and their synthetic analogues in reversed-phase high-performance liquid chromatography. Chromatographic separations were achieved applying ZORBAX SB-C18 column and two different mobile phases: methanol-water and acetonitrile-water. Chromatographic lipophilicity of the analyzed compounds was defined by logk0 constant and correlated with in silico molecular descriptors. According to the statistical validation parameters, obtained results indicate that the presented linear and multiple quantitative structure-retention relationship models can successfully predict the chromatographic lipophilicity of structurally similar compounds. Hierarchical cluster analyses (HCA) was applied in order to group similar compounds according to their chromatographic and in silico lipophilicity. It can be concluded that chromatographic systems with methanol-water were better for modelling of logk0. Modelling was performed in order to characterize compounds regarding their lipophilicity profiles as future drug candidates.

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